ID K9XH77_9CHRO Unreviewed; 320 AA.
AC K9XH77;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=Aldo/keto reductase {ECO:0000313|EMBL:AFZ31990.1};
GN ORFNames=Glo7428_3520 {ECO:0000313|EMBL:AFZ31990.1};
OS Gloeocapsa sp. PCC 7428.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Chroococcales; Chroococcaceae; Gloeocapsa.
OX NCBI_TaxID=1173026 {ECO:0000313|EMBL:AFZ31990.1, ECO:0000313|Proteomes:UP000010476};
RN [1] {ECO:0000313|EMBL:AFZ31990.1, ECO:0000313|Proteomes:UP000010476}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 7428 {ECO:0000313|EMBL:AFZ31990.1,
RC ECO:0000313|Proteomes:UP000010476};
RG US DOE Joint Genome Institute;
RA Gugger M., Coursin T., Rippka R., Tandeau De Marsac N., Huntemann M.,
RA Wei C.-L., Han J., Detter J.C., Han C., Tapia R., Davenport K.,
RA Daligault H., Erkkila T., Gu W., Munk A.C.C., Teshima H., Xu Y., Chain P.,
RA Chen A., Krypides N., Mavromatis K., Markowitz V., Szeto E., Ivanova N.,
RA Mikhailova N., Ovchinnikova G., Pagani I., Pati A., Goodwin L., Peters L.,
RA Pitluck S., Woyke T., Kerfeld C.;
RT "Finished chromosome of genome of Gloeocapsa sp. PCC 7428.";
RL Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP003646; AFZ31990.1; -; Genomic_DNA.
DR RefSeq; WP_015189859.1; NC_019745.1.
DR AlphaFoldDB; K9XH77; -.
DR STRING; 1173026.Glo7428_3520; -.
DR KEGG; glp:Glo7428_3520; -.
DR PATRIC; fig|1173026.3.peg.3723; -.
DR eggNOG; COG0667; Bacteria.
DR HOGENOM; CLU_023205_2_3_3; -.
DR OrthoDB; 9809990at2; -.
DR Proteomes; UP000010476; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd19085; AKR_AKR11B3; 1.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43364:SF16; NADH-SPECIFIC METHYLGLYOXAL REDUCTASE; 1.
DR PANTHER; PTHR43364; NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000010476}.
FT DOMAIN 15..303
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 57
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 116
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 83
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 320 AA; 35905 MW; D7F77B2ACC1D5725 CRC64;
MEKRRLGTTD IQITPILMGT WQAGQKQWVG IEDKESIKAI RAAVDAGITT IDTAEVYGNG
HSEQVIAQAL SDVPHSHIVY ATKVFANHLK YDQVLEACDR SLKNLKIDYI DLYQIHWPSG
SFNTEIVPIE ETMSALNQLK QQGKIRAIGV SNFSRTQLEE AAQYGRIDSI QPPYSLFWRW
VEKDVMPYCV ENNISILAYS PLAQGLLTGK FGRGHQFDPQ DNRAKNKLFQ GENYERAQQA
LEKLRPIAER HQASLANLAI AWLIAQPQTQ AIVGARNAEQ AVGNAKAAEV KLTSEELAEI
DAIGRIVTDH LDNNPVMWNW
//
