ID K9Y6K5_HALP7 Unreviewed; 575 AA.
AC K9Y6K5;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Rqc2 homolog RqcH {ECO:0000256|HAMAP-Rule:MF_00844};
DE Short=RqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN Name=rqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN OrderedLocusNames=PCC7418_0207 {ECO:0000313|EMBL:AFZ42444.1};
OS Halothece sp. (strain PCC 7418) (Synechococcus sp. (strain PCC 7418)).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Chroococcales; Halothecacae; Halothece cluster; Halothece.
OX NCBI_TaxID=65093 {ECO:0000313|EMBL:AFZ42444.1, ECO:0000313|Proteomes:UP000010481};
RN [1] {ECO:0000313|Proteomes:UP000010481}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 7418 {ECO:0000313|Proteomes:UP000010481};
RX PubMed=23277585; DOI=10.1073/pnas.1217107110;
RA Shih P.M., Wu D., Latifi A., Axen S.D., Fewer D.P., Talla E., Calteau A.,
RA Cai F., Tandeau de Marsac N., Rippka R., Herdman M., Sivonen K.,
RA Coursin T., Laurent T., Goodwin L., Nolan M., Davenport K.W., Han C.S.,
RA Rubin E.M., Eisen J.A., Woyke T., Gugger M., Kerfeld C.A.;
RT "Improving the coverage of the cyanobacterial phylum using diversity-driven
RT genome sequencing.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:1053-1058(2013).
CC -!- FUNCTION: Part of the ribosome quality control system (RQC). Recruits
CC Ala-charged tRNA and directs the elongation of stalled nascent chains
CC on 50S ribosomal subunits, leading to non-templated C-terminal Ala
CC extensions (Ala tail). The Ala tail promotes nascent chain degradation.
CC May add between 1 and at least 8 Ala residues. Binds to stalled 50S
CC ribosomal subunits. {ECO:0000256|HAMAP-Rule:MF_00844}.
CC -!- SUBUNIT: Associates with stalled 50S ribosomal subunits.
CC {ECO:0000256|HAMAP-Rule:MF_00844}.
CC -!- SIMILARITY: Belongs to the NEMF family. {ECO:0000256|HAMAP-
CC Rule:MF_00844}.
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DR EMBL; CP003945; AFZ42444.1; -; Genomic_DNA.
DR RefSeq; WP_015224322.1; NC_019779.1.
DR AlphaFoldDB; K9Y6K5; -.
DR STRING; 65093.PCC7418_0207; -.
DR KEGG; hao:PCC7418_0207; -.
DR PATRIC; fig|65093.3.peg.217; -.
DR eggNOG; COG1293; Bacteria.
DR HOGENOM; CLU_022481_1_0_3; -.
DR OrthoDB; 9766163at2; -.
DR Proteomes; UP000010481; Chromosome.
DR GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:UniProtKB-UniRule.
DR Gene3D; 2.30.310.10; ibrinogen binding protein from staphylococcus aureus domain; 1.
DR HAMAP; MF_00844_B; RqcH_B; 1.
DR InterPro; IPR008532; NFACT_RNA-bd.
DR InterPro; IPR043682; RqcH_bacterial.
DR PANTHER; PTHR15239; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR PANTHER; PTHR15239:SF6; RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF; 1.
DR Pfam; PF05670; NFACT-R_1; 1.
DR Pfam; PF18297; NFACT-R_2; 1.
DR Pfam; PF05833; NFACT_N; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|HAMAP-Rule:MF_00844};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW Rule:MF_00844}; Reference proteome {ECO:0000313|Proteomes:UP000010481};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW Rule:MF_00844};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555, ECO:0000256|HAMAP-
KW Rule:MF_00844}.
FT DOMAIN 455..546
FT /note="NFACT RNA-binding"
FT /evidence="ECO:0000259|Pfam:PF05670"
FT REGION 157..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 394..424
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00844"
SQ SEQUENCE 575 AA; 66510 MW; 41E91ABE0BD2CB40 CRC64;
MQPVDLTTLR AVCAELRSLW LPARLEQVYQ RDRATIALAL RTLQGRDWLT LSWHPQAARI
CIADPPPRTP DTFTFSDQLR HQLQGLALTG IPLISPWERV IDFQFAPRPG DDPLWHLYAE
IMGKYSNVIL TDAKQQIITA AHQVSPEKSK LRPIQTGQLY EPPPALTGDI PSREESQDRW
QEKVSLIPGE LKRQLLKTYR GLGPNLVTAM IQRAGLNPQQ TTDTLTSENW QTLFQVWQEW
LEILETEQFQ PGWTENGFTV LGWGMIEAVS SVQVLLKTYY SEQLNQQSFQ QLHHQLLQKV
GSLIKKQVQK QQTFQERLQQ SDDAEMERQR GDLLMAYSYQ WQPGQTSMEL PDFETGELVK
IPLNPEKNAV QNAQAYYKRH QKLKRARQAV EPLLEETNRE IKYLQQVEAA LQQLERYQKD
EDLQTLKEIQ EELIEQGYII PQRERGSTEE AQPITYKTPS GYEVLIGRNN RQNDQLTFRT
AVDYDLWFHS QEIPGSHVLL RLPPGAVPDQ NDLQFVANIA AYYSRARESQ QVPVIYTKPK
YVYKPKGAKP GMALYDHETV IWGYPEMVAD RIIEK
//
