ID K9ZLX4_ANACC Unreviewed; 895 AA.
AC K9ZLX4;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=Anacy_3953 {ECO:0000313|EMBL:AFZ59325.1};
OS Anabaena cylindrica (strain ATCC 27899 / PCC 7122).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae; Anabaena.
OX NCBI_TaxID=272123 {ECO:0000313|EMBL:AFZ59325.1, ECO:0000313|Proteomes:UP000010474};
RN [1] {ECO:0000313|Proteomes:UP000010474}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27899 / PCC 7122 {ECO:0000313|Proteomes:UP000010474};
RX PubMed=23277585; DOI=10.1073/pnas.1217107110;
RA Shih P.M., Wu D., Latifi A., Axen S.D., Fewer D.P., Talla E., Calteau A.,
RA Cai F., Tandeau de Marsac N., Rippka R., Herdman M., Sivonen K.,
RA Coursin T., Laurent T., Goodwin L., Nolan M., Davenport K.W., Han C.S.,
RA Rubin E.M., Eisen J.A., Woyke T., Gugger M., Kerfeld C.A.;
RT "Improving the coverage of the cyanobacterial phylum using diversity-driven
RT genome sequencing.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:1053-1058(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; CP003659; AFZ59325.1; -; Genomic_DNA.
DR RefSeq; WP_015215943.1; NZ_AP018166.1.
DR AlphaFoldDB; K9ZLX4; -.
DR STRING; 272123.Anacy_3953; -.
DR REBASE; 58185; Acy7122ORF3953P.
DR KEGG; acy:Anacy_3953; -.
DR PATRIC; fig|272123.3.peg.4295; -.
DR eggNOG; COG1002; Bacteria.
DR HOGENOM; CLU_005831_1_1_3; -.
DR OrthoDB; 564694at2; -.
DR Proteomes; UP000010474; Chromosome.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR046819; MmeI_hel.
DR InterPro; IPR046816; MmeI_Mtase.
DR InterPro; IPR046817; MmeI_N.
DR InterPro; IPR046820; MmeI_TRD.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841:SF6; DNA METHYLTRANSFERASE A; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF20465; MmeI_hel; 1.
DR Pfam; PF20473; MmeI_Mtase; 1.
DR Pfam; PF20464; MmeI_N; 1.
DR Pfam; PF20466; MmeI_TRD; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:AFZ59325.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000010474};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 11..181
FT /note="MmeI-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF20464"
FT DOMAIN 188..258
FT /note="MmeI-like helicase spacer"
FT /evidence="ECO:0000259|Pfam:PF20465"
FT DOMAIN 336..568
FT /note="MmeI-like DNA-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF20473"
FT DOMAIN 604..797
FT /note="MmeI-like target recognition"
FT /evidence="ECO:0000259|Pfam:PF20466"
SQ SEQUENCE 895 AA; 102919 MW; C110BC870D9C2EE2 CRC64;
MVAATPESLA KFVSFCQQHI TGQERKEAQT FLDRFFRAFG HEGALEAGAT YEEAIKKSSK
QGKTGFADLV WKPRVLIEMK KRGEDLSKHY SQAFDYWTRL VPNRPKYVIL CNFDEFWIFD
FDIQLDTPVD KIALEQLPER AGALVFMELG QKTPVFQNNQ VEVTERAARR MGELLLELEK
RGIEKLTAQR FILQCVLAMF AEDRQLLPHD MFVSCVQDCK NGASSYDVLG GLFREMNQLG
KTPAGRYQGV DYFNGGLFSQ IHAIELTREE LNFLDVSARE DWSKVRPAIF GNLFEETVDK
KERHARGIHY TSEADIMKIV RPTISRFWEE RIEEASTIKE LSGLQLELQS YRVLDPACGS
GNFLYMAYQE LKRIESLLLE KMQQKRKSED KQMQMGLVTP LQFYGMDTNP FAVELARVTL
MIARKIAIDN LNLTEPALPL DTLDNNIVCQ DALFSEWVKA DAMIGNPPFL GGNRIRLDLG
DEYAECIFRK FSEVKSQVDF CVYWFRLAHE SLNGKGRAGL VGTNSISQGN SRYASLDYIT
RNSGYIHEAI PTQNWSGEAQ VYVSIVNWCY EKAFKLYLDN QVVTKISSSL SSTVDVSIAI
KLNSNLDLCF EGVKPNAKGF IITENQAQEW IKSNFKNAVV IKLFLDAGDL TKVPHGKPSR
WVIDFENMSL EEASDYILPF EHVRVTVKPE RENNREPVLR EKWWRFKRTH TAMRQALISL
KTYFTVPAHS KWFIFVPSFS NWLPNNSTKV VASDDFYILG ILTSSVHRVW VKAQSSTLGE
TTRYTHNTCF ETFPFPQTPD AKLVQKIRAK SKELHQYRTA QMELQQWGIT TLYNKFFHEP
TSQLYQLHQQ LDKLVMQAYD FHSNDDLLEK LLNLNTELAE KEKQGIKIIG PWSPN
//
