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Database: UniProt
Entry: KCNS1_MACMU
LinkDB: KCNS1_MACMU
Original site: KCNS1_MACMU 
ID   KCNS1_MACMU             Reviewed;         529 AA.
AC   A4K2T1;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   27-SEP-2017, entry version 52.
DE   RecName: Full=Potassium voltage-gated channel subfamily S member 1;
DE   AltName: Full=Delayed-rectifier K(+) channel alpha subunit 1;
GN   Name=KCNS1;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=17267810; DOI=10.1101/gr.6004607;
RG   NISC comparative sequencing program;
RA   Hurle B., Swanson W., Green E.D.;
RT   "Comparative sequence analyses reveal rapid and divergent evolutionary
RT   changes of the WFDC locus in the primate lineage.";
RL   Genome Res. 17:276-286(2007).
CC   -!- FUNCTION: Potassium channel subunit that does not form functional
CC       channels by itself. Can form functional heterotetrameric channels
CC       with KCNB1 and KCNB2; modulates the delayed rectifier voltage-
CC       gated potassium channel activation and deactivation rates of KCNB1
CC       and KCNB2. {ECO:0000250|UniProtKB:O35173}.
CC   -!- SUBUNIT: Heteromultimer with KCNB1 and KCNB2. Does not form
CC       homomultimers. {ECO:0000250|UniProtKB:O35173}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000250|UniProtKB:O35173}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:O35173}. Note=May not reach the plasma
CC       membrane but remain in an intracellular compartment in the absence
CC       of KCNB1 or KCNB2. {ECO:0000250|UniProtKB:O35173}.
CC   -!- DOMAIN: The transmembrane segment S4 functions as voltage-sensor
CC       and is characterized by a series of positively charged amino acids
CC       at every third position. Channel opening and closing is effected
CC       by a conformation change that affects the position and orientation
CC       of the voltage-sensor paddle formed by S3 and S4 within the
CC       membrane. A transmembrane electric field that is positive inside
CC       would push the positively charged S4 segment outwards, thereby
CC       opening the pore, while a field that is negative inside would pull
CC       the S4 segment inwards and close the pore. Changes in the position
CC       and orientation of S4 are then transmitted to the activation gate
CC       formed by the inner helix bundle via the S4-S5 linker region.
CC       {ECO:0000250|UniProtKB:P63142}.
CC   -!- SIMILARITY: Belongs to the potassium channel family. S (TC
CC       1.A.1.2) subfamily. Kv9.1/KCNS1 sub-subfamily. {ECO:0000305}.
DR   EMBL; DP000043; ABO52966.1; -; Genomic_DNA.
DR   RefSeq; XP_015004318.1; XM_015148832.1.
DR   UniGene; Mmu.17803; -.
DR   ProteinModelPortal; A4K2T1; -.
DR   SMR; A4K2T1; -.
DR   STRING; 9544.ENSMMUP00000017362; -.
DR   GeneID; 711715; -.
DR   CTD; 3787; -.
DR   eggNOG; KOG3713; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   HOGENOM; HOG000231016; -.
DR   HOVERGEN; HBG052230; -.
DR   InParanoid; A4K2T1; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR   GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0006813; P:potassium ion transport; ISS:UniProtKB.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR   GO; GO:1902259; P:regulation of delayed rectifier potassium channel activity; ISS:UniProtKB.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR   InterPro; IPR003971; K_chnl_volt-dep_Kv9.
DR   InterPro; IPR011333; SKP1/BTB/POZ.
DR   InterPro; IPR003131; T1-type_BTB.
DR   InterPro; IPR028325; VG_K_chnl.
DR   PANTHER; PTHR11537; PTHR11537; 1.
DR   Pfam; PF02214; BTB_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR00169; KCHANNEL.
DR   PRINTS; PR01494; KV9CHANNEL.
DR   PRINTS; PR01491; KVCHANNEL.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Complete proteome; Ion channel; Ion transport;
KW   Membrane; Potassium; Potassium channel; Potassium transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport;
KW   Voltage-gated channel.
FT   CHAIN         1    529       Potassium voltage-gated channel subfamily
FT                                S member 1.
FT                                /FTId=PRO_0000289618.
FT   TOPO_DOM      1    217       Cytoplasmic.
FT                                {ECO:0000250|UniProtKB:P63142}.
FT   TRANSMEM    218    239       Helical; Name=Segment S1.
FT                                {ECO:0000250|UniProtKB:P63142}.
FT   TOPO_DOM    240    270       Extracellular.
FT                                {ECO:0000250|UniProtKB:P63142}.
FT   TRANSMEM    271    293       Helical; Name=Segment S2.
FT                                {ECO:0000250|UniProtKB:P63142}.
FT   TOPO_DOM    294    304       Cytoplasmic.
FT                                {ECO:0000250|UniProtKB:P63142}.
FT   TRANSMEM    305    322       Helical; Name=Segment S3.
FT                                {ECO:0000250|UniProtKB:P63142}.
FT   TOPO_DOM    323    340       Extracellular.
FT                                {ECO:0000250|UniProtKB:P63142}.
FT   TRANSMEM    341    361       Helical; Voltage-sensor; Name=Segment S4.
FT                                {ECO:0000250|UniProtKB:P63142}.
FT   TOPO_DOM    362    376       Cytoplasmic.
FT                                {ECO:0000250|UniProtKB:P63142}.
FT   TRANSMEM    377    398       Helical; Name=Segment S5.
FT                                {ECO:0000250|UniProtKB:P63142}.
FT   TOPO_DOM    399    411       Extracellular.
FT                                {ECO:0000250|UniProtKB:P63142}.
FT   INTRAMEM    412    423       Helical; Name=Pore helix.
FT                                {ECO:0000250|UniProtKB:P63142}.
FT   INTRAMEM    424    431       {ECO:0000250|UniProtKB:P63142}.
FT   TOPO_DOM    432    438       Extracellular.
FT                                {ECO:0000250|UniProtKB:P63142}.
FT   TRANSMEM    439    467       Helical; Name=Segment S6.
FT                                {ECO:0000250|UniProtKB:P63142}.
FT   TOPO_DOM    468    529       Cytoplasmic.
FT                                {ECO:0000250|UniProtKB:P63142}.
FT   MOTIF       424    429       Selectivity filter.
FT                                {ECO:0000250|UniProtKB:P63142}.
FT   COMPBIAS    250    259       Poly-Ala.
SQ   SEQUENCE   529 AA;  58334 MW;  986AEF7E1AB2BC06 CRC64;
     MLMLLVRGTH YESLRSKVVL PTPLGGRGTE ALVSECPSPD TGIRWRQSDE ALRVNVGGVR
     RLLSARALAR FPGTRLGRLQ AAASEEQARR LCDDYDAAAR EFYFDRHPGF FLGLLHFYRT
     GHLHVLDELC VFAFGQEADY WGLGENALAA CCRARYLERR LTQPRAWDED SDTPSSVDPC
     PDEISDVQRE LARYGAARCG RLRRRLWLTM ENPGYSLPSK LFSCVSISVV LASIAAMCIH
     SLPEYQAREA AAAVAAVAAG RSPEGVRDDP VLRRLEYFCI AWFSFEVSSR LLLAPSTRNF
     FCHPLNLIDI VSVLPFYLTL LAGVALGDQG GTGGKELGHL GKVVQVFRLM RIFRVLKLAR
     HSTGLRSLGA TLKHSYREVG ILLLYLAVGV SVFSGVAYTA EKEEDVGFNT IPACWWWGTV
     SMTTVGYGDV VPVTVAGKLA ASGCILGGIL VVALPITIIF NKFSHFYRRQ KALEAAVRNS
     NHQEFEDLLS SVDGVSEASL ETSRETSQEG RSADLETQAP SEPPHPQMY
//
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