ID   KHSE_METGL              Reviewed;         318 AA.
AC   O32378;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2001, sequence version 2.
DT   13-SEP-2023, entry version 78.
DE   RecName: Full=Homoserine kinase;
DE            Short=HK;
DE            Short=HSK;
DE            EC=2.7.1.39;
GN   Name=thrB;
OS   Methylobacillus glycogenes.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC   Methylophilaceae; Methylobacillus.
OX   NCBI_TaxID=406;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATR80;
RA   Motoyama H., Anazawa H., Ishino S., Teshiba S.;
RT   "Production of l-threonine by fermentation method.";
RL   Patent number JP1993207886, 20-AUG-1993.
RN   [2]
RP   IDENTIFICATION OF PROBABLE FRAMESHIFTS.
RA   Bairoch A.;
RL   Unpublished observations (DEC-2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine;
CC         Xref=Rhea:RHEA:13985, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57590, ChEBI:CHEBI:456216;
CC         EC=2.7.1.39;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine
CC       from L-aspartate: step 4/5.
CC   -!- SIMILARITY: Belongs to the pseudomonas-type ThrB family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA21850.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; D14072; BAA21850.1; ALT_FRAME; Genomic_DNA.
DR   UniPathway; UPA00050; UER00064.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004413; F:homoserine kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd05153; HomoserineK_II; 1.
DR   Gene3D; 3.90.1200.10; -; 1.
DR   HAMAP; MF_00301; Homoser_kinase_2; 1.
DR   InterPro; IPR002575; Aminoglycoside_PTrfase.
DR   InterPro; IPR005280; Homoserine_kinase_II.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   NCBIfam; TIGR00938; thrB_alt; 1.
DR   PANTHER; PTHR21064:SF6; APH DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR21064; UNCHARACTERIZED; 1.
DR   Pfam; PF01636; APH; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; ATP-binding; Kinase; Nucleotide-binding;
KW   Threonine biosynthesis; Transferase.
FT   CHAIN           1..318
FT                   /note="Homoserine kinase"
FT                   /id="PRO_0000172191"
SQ   SEQUENCE   318 AA;  35622 MW;  B3C23E33176E81C9 CRC64;
     MSVFTAVSFE QMQQWLKGYD LGELLDLQGI ASGITNTNYF VATGTGRYVL TLFEEHSAEE
     LPNFLDLMTH LAERGIPCPY PVKNIAGQAL GELNGKPAAL VSCLAGKSLD NPSPQHCAAI
     GEVLARMHLA GASFEVSIIN LRCQRWRIAR LPRWAPFLDA ENXRMLDAQL EFEQAFDTSA
     LSRGVIHADL FRDNVLMDGD KVGGVLDFYY AWNDVLFYDI AIAVXDWCVN ADGTRDVGRV
     RAFLDAYHAV RPLTEEEHAA WPGMLRVAGI RFWLSRLNDL HFPQAGELIH AKDPAYFERI
     LRKAIAAREQ LLTMWVDS
//