ID KI3X1_HUMAN Reviewed; 352 AA.
AC Q9H7L2; B7WNL0; Q8N0S4;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 2.
DT 27-MAR-2024, entry version 131.
DE RecName: Full=Putative killer cell immunoglobulin-like receptor-like protein KIR3DX1;
DE AltName: Full=Leukocyte receptor cluster member 12;
DE Flags: Precursor;
GN Name=KIR3DX1; Synonyms=KIR3DL0, LENG12;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 117-333.
RC TISSUE=Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP IDENTIFICATION, AND TISSUE SPECIFICITY.
RX PubMed=16911775; DOI=10.1186/1471-2164-7-209;
RA Sambrook J.G., Bashirova A., Andersen H., Piatak M., Vernikos G.S.,
RA Coggill P., Lifson J.D., Carrington M., Beck S.;
RT "Identification of the ancestral killer immunoglobulin-like receptor gene
RT in primates.";
RL BMC Genomics 7:209-209(2006).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in NK-cells.
CC {ECO:0000269|PubMed:16911775}.
CC -!- CAUTION: Could be the product of a pseudogene. According to
CC PubMed:16911775, it could constitute the ancestral killer
CC immunoglobulin-like receptor gene in primates. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB15757.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites and probable target of nonsense-mediated mRNA decay.; Evidence={ECO:0000305};
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DR EMBL; AC009892; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC104536; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK024467; BAB15757.1; ALT_SEQ; mRNA.
DR EMBL; CH471135; EAW72255.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9H7L2; -.
DR SMR; Q9H7L2; -.
DR IntAct; Q9H7L2; 1.
DR GlyCosmos; Q9H7L2; 1 site, No reported glycans.
DR GlyGen; Q9H7L2; 2 sites, 1 O-linked glycan (1 site).
DR iPTMnet; Q9H7L2; -.
DR PhosphoSitePlus; Q9H7L2; -.
DR BioMuta; KIR3DX1; -.
DR PeptideAtlas; Q9H7L2; -.
DR Ensembl; ENST00000614511.4; ENSP00000479122.1; ENSG00000276848.4.
DR Ensembl; ENST00000614591.1; ENSP00000484242.1; ENSG00000275918.4.
DR Ensembl; ENST00000621920.4; ENSP00000481872.1; ENSG00000276033.4.
DR UCSC; uc061crn.1; human.
DR AGR; HGNC:25043; -.
DR GeneCards; KIR3DX1; -.
DR HGNC; HGNC:25043; KIR3DX1.
DR neXtProt; NX_Q9H7L2; -.
DR HOGENOM; CLU_021100_2_1_1; -.
DR InParanoid; Q9H7L2; -.
DR PhylomeDB; Q9H7L2; -.
DR TreeFam; TF352669; -.
DR PathwayCommons; Q9H7L2; -.
DR SignaLink; Q9H7L2; -.
DR Pharos; Q9H7L2; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q9H7L2; Protein.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:UniProt.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013151; Immunoglobulin.
DR PANTHER; PTHR11738:SF153; KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR-LIKE PROTEIN KIR3DX1-RELATED; 1.
DR PANTHER; PTHR11738; MHC CLASS I NK CELL RECEPTOR; 1.
DR Pfam; PF00047; ig; 3.
DR SMART; SM00409; IG; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 5: Uncertain;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Reference proteome;
KW Repeat; Secreted; Signal.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..352
FT /note="Putative killer cell immunoglobulin-like receptor-
FT like protein KIR3DX1"
FT /id="PRO_0000349175"
FT DOMAIN 17..112
FT /note="Ig-like C2-type 1"
FT DOMAIN 224..311
FT /note="Ig-like C2-type 2"
FT CARBOHYD 78
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 49..94
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 244..295
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 352 AA; 38777 MW; B7EBD744D0061035 CRC64;
MAPKLITVLC LGFCLNQKIC PHAGAQDKFS LSAWPSPVVP LGGRVTLSCH SHLRFVIWTI
FQTTGTRSHE LHTGLSNNIT ISPVTPEHAG TYRCVGIYKH ASKWSAESNS LKIIVTGLFT
KPSISAHPSS LVHAGARVSL RCHSELAFDE FILYKEGHIQ HSQQLDQGME AGIHYVEAVF
SMGPVTPAHA GAYRCCGCFS HSRYEWSAPS DPLDIVITGK YKKPSLSTQV DPMMRLGEKL
TLFCSSEISF DQYHLFRHGV AHGQWLSGGQ RHREAFQANF SVGRATPVPG GTYRCYGSFN
DSPYKPPVTR CNFTPQETLR VLLCHSQNPP LNLTHLALKD SPATCICSLD SQ
//
