ID KIBRA_XENTR Reviewed; 1108 AA.
AC A4IIJ3;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=Protein KIBRA;
DE AltName: Full=WW domain-containing protein 1;
GN Name=wwc1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negative regulator of the Hippo signaling pathway, also known
CC as the Salvador-Warts-Hippo (SWH) pathway.
CC {ECO:0000250|UniProtKB:Q8IX03}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q8IX03}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8IX03}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q8IX03}. Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:Q8IX03}.
CC -!- DOMAIN: The C2-domain mediates homodimerization.
CC {ECO:0000250|UniProtKB:Q8IX03}.
CC -!- SIMILARITY: Belongs to the WWC family. KIBRA subfamily. {ECO:0000305}.
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DR EMBL; BC136041; AAI36042.1; -; mRNA.
DR RefSeq; NP_001096212.1; NM_001102742.1.
DR AlphaFoldDB; A4IIJ3; -.
DR SMR; A4IIJ3; -.
DR PaxDb; 8364-ENSXETP00000035914; -.
DR DNASU; 100124763; -.
DR GeneID; 100124763; -.
DR KEGG; xtr:100124763; -.
DR AGR; Xenbase:XB-GENE-985007; -.
DR CTD; 23286; -.
DR Xenbase; XB-GENE-985007; wwc1.
DR eggNOG; KOG3209; Eukaryota.
DR InParanoid; A4IIJ3; -.
DR OMA; QVTVVSM; -.
DR OrthoDB; 1334597at2759; -.
DR Proteomes; UP000008143; Chromosome 3.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISS:UniProtKB.
DR CDD; cd08680; C2_Kibra; 1.
DR CDD; cd00201; WW; 2.
DR Gene3D; 2.20.70.10; -; 2.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037771; C2_WWC.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR14791; BOMB/KIRA PROTEINS; 1.
DR PANTHER; PTHR14791:SF22; PROTEIN KIBRA; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00397; WW; 2.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; Nucleus; Reference proteome; Repeat; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..1108
FT /note="Protein KIBRA"
FT /id="PRO_0000309489"
FT DOMAIN 6..39
FT /note="WW 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00224"
FT DOMAIN 53..86
FT /note="WW 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00224"
FT DOMAIN 653..776
FT /note="C2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT REGION 434..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 523..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 828..861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 111..247
FT /evidence="ECO:0000255"
FT COILED 294..329
FT /evidence="ECO:0000255"
FT COILED 360..434
FT /evidence="ECO:0000255"
FT COILED 998..1065
FT /evidence="ECO:0000255"
FT COMPBIAS 523..546
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 835..849
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1108 AA; 125267 MW; 1B3994E1332E2AE1 CRC64;
MIRKELPLPE GWEEARDVDG KVYYIDHTSK TTSWIDPRDR FTKPLTFADC IGDELPLGWE
ESYDTQVGVY YIDHNSQTTQ IEDPRVQWRR EQERMLKDYL VLAQEALLAQ KEIYQVKQQR
LELAQKEYRT LNDVWKHKVG SQTSLVSGSS SSSKYDPDIL KAEIATTKSR VNKLKREMVF
LRQELQYKEN GYQTLKEIDL KMSKNHCAYK LDEAQAILNE MKTIKKAITS GEREKQDLIQ
SLAELKNGFL VDKGSQSDLW ASNTSLASSA NSLSRQYLNV SSQTDISGNL SVVSNNHLAE
KVRLQLRYEE AKRRIANIKI QLAKIDSDAW PGVLDSERDR LILISEKEEL LKEMRFISPR
KWSQSEVERL ESEKKQLEED LQAARDTQSK ALTERLKMSS KRNQLVKELE ETTRLIASLQ
AQLKCLSTSM QSLSSGSSPG SLASSRGSLV TSSQDSSTSA SVSDLYYEQL DHLDSEYQNK
VDFLIQEGAM GYRPSGCITT IHENEVVRSQ KTDPANRVKA LRSLSGTPKS MTSLSPRSSL
SSPSPPCSPL VTDPLLTVDA FLSQIDFEDI DLPLSFTELN VNAGGDSYQH ETDEEPSGQG
LSCLGVSSLS VAGVSAAVSD ESVTGDSGVY EATNQRTLME NAVFDGEDSE MMDTAKIKIG
MKYDEKNKHF AVFVIQLDNL AALLLHQNEK LYIRVAVLPC SESTSCLFRT RTLEQSDTLL
YNEMFLVSTS HSALRQKTLR VDVCTRQSNH HEECLGGSQI SLADVCHSEE QEAHWYNLLS
YRYLKRQSKT SKQKISCCEE SGIENPDSVS ALLKQTAAEL EAVRKQIGES TDPPEYIWPE
KKDNVPDEDG ISENEGEEEF DGDVQCETEE SDMQAATDSA SVKVDKETNT EGLAMSLSSV
RPKDKRAATP MQAPFIRGNT IIRSKTFSPG PQSQYICRLN RSDSESSTLS KKPPFVRNAM
ERRSVRVKRP SVKSTGSERL IRTSLDLELD LQASRTWHHQ LTQEISVLRE LKEQLEQAKR
LGENELPQRV KDDETFKVML RQVEKQVQKI EQKYEMQADK MMRAAAKDVH RLRGQSSKEP
LEVQSFREKM AFFTRPRMNL PTLTADDV
//
