ID KRT84_MOUSE Reviewed; 603 AA.
AC Q99M73; E9QMQ6; Q1RME6; Q61862;
DT 29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 24-JAN-2024, entry version 139.
DE RecName: Full=Keratin, type II cuticular Hb4;
DE AltName: Full=65 kDa type II keratin;
DE AltName: Full=Keratin-84;
DE Short=K84;
DE AltName: Full=Type II hair keratin Hb4;
DE AltName: Full=Type-II keratin Kb24;
GN Name=Krt84; Synonyms=Krt2-16, Krthb4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C3H/HeN;
RX PubMed=12399393; DOI=10.1093/genetics/162.2.831;
RA Poirier C., Yoshiki A., Fujiwara K., Guenet J.-L., Kusakabe M.;
RT "Hague (Hag): a new mouse hair mutation with an unstable semidominant
RT allele.";
RL Genetics 162:831-840(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 306-603, TISSUE SPECIFICITY, AND INDUCTION.
RC STRAIN=NMRI; TISSUE=Tail epidermis;
RX PubMed=1385239; DOI=10.1111/j.1432-0436.1992.tb00671.x;
RA Tobiasch E., Winter H., Schweizer J.;
RT "Structural features and sites of expression of a new murine 65 kD and 48
RT kD hair-related keratin pair, associated with a special type of
RT parakeratotic epithelial differentiation.";
RL Differentiation 50:163-178(1992).
CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: In skin, only expressed in the suprabasal cells of
CC tail scale epidermis. Suprabasally expressed in stratified squamous
CC epithelia and also in the posterior unit of the complex filiform
CC papillae of tongue. Expressed in rare anatomical sites in which an
CC orthokeratinized stratum corneum would be too soft and a hard
CC keratinized structure would be too rigid to meet the functional
CC requirement of the respective epithelia. {ECO:0000269|PubMed:1385239}.
CC -!- INDUCTION: mRNA synthesis is suppressed during retinoic acid-mediated
CC orthokeratotic conversion of tail scale epidermis.
CC {ECO:0000269|PubMed:1385239}.
CC -!- MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I
CC (acidic) and II (neutral to basic).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; AY028607; AAK26233.1; -; mRNA.
DR EMBL; AC103674; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC114971; AAI14972.1; -; mRNA.
DR EMBL; X65505; CAA46479.1; -; mRNA.
DR CCDS; CCDS27853.1; -.
DR RefSeq; NP_032500.2; NM_008474.2.
DR AlphaFoldDB; Q99M73; -.
DR SMR; Q99M73; -.
DR BioGRID; 201032; 1.
DR STRING; 10090.ENSMUSP00000023720; -.
DR iPTMnet; Q99M73; -.
DR PhosphoSitePlus; Q99M73; -.
DR SwissPalm; Q99M73; -.
DR jPOST; Q99M73; -.
DR MaxQB; Q99M73; -.
DR PaxDb; 10090-ENSMUSP00000023720; -.
DR PeptideAtlas; Q99M73; -.
DR ProteomicsDB; 263465; -.
DR Antibodypedia; 43076; 109 antibodies from 19 providers.
DR DNASU; 16680; -.
DR Ensembl; ENSMUST00000023720.8; ENSMUSP00000023720.8; ENSMUSG00000044294.9.
DR GeneID; 16680; -.
DR KEGG; mmu:16680; -.
DR UCSC; uc007xtm.2; mouse.
DR AGR; MGI:96700; -.
DR CTD; 3890; -.
DR MGI; MGI:96700; Krt84.
DR VEuPathDB; HostDB:ENSMUSG00000044294; -.
DR eggNOG; ENOG502QWIE; Eukaryota.
DR GeneTree; ENSGT00940000162040; -.
DR HOGENOM; CLU_012560_6_1_1; -.
DR InParanoid; Q99M73; -.
DR OMA; EQKCARS; -.
DR OrthoDB; 4640531at2759; -.
DR PhylomeDB; Q99M73; -.
DR TreeFam; TF317854; -.
DR Reactome; R-MMU-6805567; Keratinization.
DR Reactome; R-MMU-6809371; Formation of the cornified envelope.
DR BioGRID-ORCS; 16680; 4 hits in 76 CRISPR screens.
DR ChiTaRS; Krt84; mouse.
DR PRO; PR:Q99M73; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q99M73; Protein.
DR Bgee; ENSMUSG00000044294; Expressed in tail skin and 25 other cell types or tissues.
DR Genevisible; Q99M73; MM.
DR GO; GO:0045111; C:intermediate filament cytoskeleton; IDA:UniProtKB.
DR GO; GO:0045095; C:keratin filament; ISO:MGI.
DR GO; GO:0030280; F:structural constituent of skin epidermis; IDA:UniProtKB.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR GO; GO:0031424; P:keratinization; IBA:GO_Central.
DR GO; GO:0045616; P:regulation of keratinocyte differentiation; IDA:UniProtKB.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF17; KERATIN, TYPE II CUTICULAR HB4; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT CHAIN 1..603
FT /note="Keratin, type II cuticular Hb4"
FT /id="PRO_0000063701"
FT DOMAIN 173..484
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..173
FT /note="Head"
FT REGION 174..208
FT /note="Coil 1A"
FT REGION 209..218
FT /note="Linker 1"
FT REGION 219..319
FT /note="Coil 1B"
FT REGION 320..336
FT /note="Linker 12"
FT REGION 337..480
FT /note="Coil 2"
FT REGION 481..603
FT /note="Tail"
FT REGION 579..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 111
FT /note="P -> T (in Ref. 1; AAK26233 and 3; AAI14972)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 603 AA; 64983 MW; 63B1DCC4A0A8B95A CRC64;
MSCRSYRVSS GRRVGSFSSC SAMAPQHLNR FRSSSVSCRS GPGFRGLGGF GSRSVINFGS
SSPRIAVGCS RPVRCGVGFG AGSGMAFGSG DGLGFRASSG VGLGFGAGGC PSYGFGGPGF
GGPGFGGPGF GYRIGGIGGP SAPAITAVTV NQSLLTPLNL EIDPNAQRVK RDEKEQIKTL
NNKFASFIDK VRFLEQQNKL LETKWSFLQE QKCARSNLEP LFDNYITNLR RQLDVLSSDQ
ARLQAERNHL QDILEGFKKK YEEEVVFRAN AENEFVALKK DVDAAFLNKS DLEANVDTLI
QETEFLKALY HEEIEMLQSH ISETSVIVKM DNSRDLNLDG IIAEVKAQYE EVARRSRADV
ESWYQTKYEE MRVTAGQHCD NLRSTRDEIN ELTRLIQRLK AEIEHTKAQC AKLEAAVAEA
EQQGEAALND AKCKLADLEG ALQQAKQDMA RQLREYQELM NVKLALDIEI VTYRRLLEGE
EIRICEGVGP VNISVSSSRG GVLCGPELVS GSSLSHNGGV TFSTSSSIRA TGGVLASSSL
RAGGDLLSSG SRGGSVLVGD ACAPSIPCAL PTEGGFSSCS GGRGNRSSSV RFSSTTTSRR
TRY
//
