ID   KT222_BOVIN             Reviewed;         295 AA.
AC   Q2KI75;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   24-JAN-2024, entry version 96.
DE   RecName: Full=Keratin-like protein KRT222;
DE   AltName: Full=Keratin-222;
GN   Name=KRT222;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   EMBL; BC112742; AAI12743.1; -; mRNA.
DR   RefSeq; NP_001039502.1; NM_001046037.1.
DR   RefSeq; XP_005220765.1; XM_005220708.3.
DR   AlphaFoldDB; Q2KI75; -.
DR   SMR; Q2KI75; -.
DR   STRING; 9913.ENSBTAP00000040702; -.
DR   PaxDb; 9913-ENSBTAP00000040702; -.
DR   Ensembl; ENSBTAT00000043110.4; ENSBTAP00000040702.3; ENSBTAG00000030539.4.
DR   GeneID; 509747; -.
DR   KEGG; bta:509747; -.
DR   CTD; 125113; -.
DR   VEuPathDB; HostDB:ENSBTAG00000030539; -.
DR   VGNC; VGNC:83291; KRT222.
DR   eggNOG; ENOG502QQ07; Eukaryota.
DR   GeneTree; ENSGT00940000159655; -.
DR   HOGENOM; CLU_101833_0_0_1; -.
DR   InParanoid; Q2KI75; -.
DR   OMA; EEGCLHT; -.
DR   OrthoDB; 4111230at2759; -.
DR   TreeFam; TF332442; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000030539; Expressed in occipital lobe and 27 other cell types or tissues.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.20.5.500; Single helix bin; 1.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR002957; Keratin_I.
DR   PANTHER; PTHR47082; KERATIN-LIKE PROTEIN KRT222; 1.
DR   PANTHER; PTHR47082:SF1; KERATIN-LIKE PROTEIN KRT222; 1.
DR   Pfam; PF00038; Filament; 1.
DR   PRINTS; PR01248; TYPE1KERATIN.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT   CHAIN           1..295
FT                   /note="Keratin-like protein KRT222"
FT                   /id="PRO_0000344214"
FT   DOMAIN          1..150
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   COILED          1..151
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   295 AA;  34263 MW;  FBDF833092C99196 CRC64;
     MELSQLLNEI RANYEKLLTR NQIETVLSTR IQLEEDLSKK MDKDEEALKA AQAELKEARR
     QWHHLQVEIE SLHAVERGLE NSLHASEQHY QMQLQDLEAV IEGLEKELQE VRRGIERQLQ
     EHEMLLNTKM RLEQEIATYR RLLEKEEIRY YGSIQGGKKE QKPTTSRVGF VLPSAIINEI
     SFSTKVPQKY EDEKVETVTK QAILNGNIVK ESTEAHGTIQ TEKVDEVIKE WEGSFFKDNP
     RLRKKSVSLR FDLHLAATDE GCSQTKQDNL PDIEVRLIMR RSCSIPSIKR PSTTN
//