ID L0CNW0_9LAMI Unreviewed; 252 AA.
AC L0CNW0;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=chalcone synthase {ECO:0000256|ARBA:ARBA00012975};
DE EC=2.3.1.74 {ECO:0000256|ARBA:ARBA00012975};
DE Flags: Fragment;
GN Name=CHS {ECO:0000313|EMBL:AGA17758.1};
OS Tinnea rhodesiana.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Lamiales; Lamiaceae; Scutellarioideae; Tinnea.
OX NCBI_TaxID=992797 {ECO:0000313|EMBL:AGA17758.1};
RN [1] {ECO:0000313|EMBL:AGA17758.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23226402; DOI=10.1371/journal.pone.0050844;
RA Chiang Y.C., Huang B.H., Liao P.C.;
RT "Diversification, biogeographic pattern, and demographic history of
RT Taiwanese Scutellaria species inferred from nuclear and chloroplast DNA.";
RL PLoS ONE 7:E50844-E50844(2012).
RN [2] {ECO:0000313|EMBL:AGA17758.1}
RP NUCLEOTIDE SEQUENCE.
RA Chiang Y.-C., Huang B.-H., Liao P.-C.;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The primary product of this enzyme is 4,2',4',6'-
CC tetrahydroxychalcone (also termed naringenin-chalcone or chalcone)
CC which can under specific conditions spontaneously isomerize into
CC naringenin. {ECO:0000256|ARBA:ARBA00002969}.
CC -!- PATHWAY: Secondary metabolite biosynthesis; flavonoid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004966}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000256|ARBA:ARBA00005531,
CC ECO:0000256|RuleBase:RU003633}.
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DR EMBL; JX985457; AGA17758.1; -; Genomic_DNA.
DR AlphaFoldDB; L0CNW0; -.
DR UniPathway; UPA00154; -.
DR GO; GO:0102128; F:chalcone synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0016210; F:naringenin-chalcone synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0009813; P:flavonoid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00831; CHS_like; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR InterPro; IPR018088; Chalcone/stilbene_synthase_AS.
DR InterPro; IPR011141; Polyketide_synthase_type-III.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11877:SF14; CHALCONE SYNTHASE; 1.
DR PANTHER; PTHR11877; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR Pfam; PF02797; Chal_sti_synt_C; 1.
DR Pfam; PF00195; Chal_sti_synt_N; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00441; CHALCONE_SYNTH; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000256|RuleBase:RU003633};
KW Flavonoid biosynthesis {ECO:0000256|ARBA:ARBA00023241};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003633}.
FT DOMAIN 1..135
FT /note="Chalcone/stilbene synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00195"
FT DOMAIN 145..252
FT /note="Chalcone/stilbene synthase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02797"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AGA17758.1"
FT NON_TER 252
FT /evidence="ECO:0000313|EMBL:AGA17758.1"
SQ SEQUENCE 252 AA; 27046 MW; E194EF5351EA282B CRC64;
RQDIVVVEVP KLGKEAAQKA IKEWGQPKSK ITHVIFCTTS GVDMPGADYQ LTKLLGLRPS
VKRFMMYQQG CFAGGTVLRM AKDLAENNAG ARVLVVCSEI TAITFRGPSD SHLDSLVGQA
LFGDGAGAVI VGSDPVVGVE RPLFQIASAA QTILPDSEGA IDGHLREVGL TFHLLKDVPG
LISKNIEKSL KEAFAPLGVS DWNSIFWVVH PGGPAILDQV EEKLALKPDI LRSTRHVLSE
YGNMSSACVL FV
//
