ID   L0DB69_SINAD            Unreviewed;       696 AA.
AC   L0DB69;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   RecName: Full=Dipeptidyl-peptidase {ECO:0000256|RuleBase:RU366067};
DE            EC=3.4.14.- {ECO:0000256|RuleBase:RU366067};
GN   OrderedLocusNames=Sinac_1501 {ECO:0000313|EMBL:AGA25881.1};
OS   Singulisphaera acidiphila (strain ATCC BAA-1392 / DSM 18658 / VKM B-2454 /
OS   MOB10).
OC   Bacteria; Planctomycetota; Planctomycetia; Isosphaerales; Isosphaeraceae;
OC   Singulisphaera.
OX   NCBI_TaxID=886293 {ECO:0000313|EMBL:AGA25881.1, ECO:0000313|Proteomes:UP000010798};
RN   [1] {ECO:0000313|EMBL:AGA25881.1, ECO:0000313|Proteomes:UP000010798}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1392 / DSM 18658 / VKM B-2454 / MOB10
RC   {ECO:0000313|Proteomes:UP000010798};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Peters L., Ovchinnikova G., Chertkov O.,
RA   Kyrpides N., Mavromatis K., Ivanova N., Brettin T., Detter J.C., Han C.,
RA   Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P.,
RA   Woyke T., Wu D., Tindall B., Pomrenke H., Brambilla E., Klenk H.-P.,
RA   Eisen J.A.;
RT   "Complete sequence of chromosome of Singulisphaera acidiphila DSM 18658.";
RL   Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the removal of dipeptides from the N-terminus of
CC       oligopeptides. {ECO:0000256|RuleBase:RU366067}.
CC   -!- SIMILARITY: Belongs to the peptidase S46 family.
CC       {ECO:0000256|ARBA:ARBA00010491, ECO:0000256|RuleBase:RU366067}.
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DR   EMBL; CP003364; AGA25881.1; -; Genomic_DNA.
DR   RefSeq; WP_015245051.1; NZ_JH621477.1.
DR   AlphaFoldDB; L0DB69; -.
DR   STRING; 886293.Sinac_1501; -.
DR   KEGG; saci:Sinac_1501; -.
DR   eggNOG; COG3591; Bacteria.
DR   HOGENOM; CLU_013776_0_0_0; -.
DR   OrthoDB; 9805367at2; -.
DR   Proteomes; UP000010798; Chromosome.
DR   GO; GO:0008239; F:dipeptidyl-peptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0070009; F:serine-type aminopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0043171; P:peptide catabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR   InterPro; IPR019500; Pep_S46.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   PANTHER; PTHR38469; -; 1.
DR   PANTHER; PTHR38469:SF1; PERIPLASMIC PEPTIDASE SUBFAMILY S1B; 1.
DR   Pfam; PF10459; Peptidase_S46; 1.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
PE   3: Inferred from homology;
KW   Aminopeptidase {ECO:0000256|ARBA:ARBA00022438,
KW   ECO:0000256|RuleBase:RU366067}; Hydrolase {ECO:0000256|RuleBase:RU366067};
KW   Protease {ECO:0000256|RuleBase:RU366067};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010798};
KW   Serine protease {ECO:0000256|RuleBase:RU366067};
KW   Signal {ECO:0000256|RuleBase:RU366067}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|RuleBase:RU366067"
FT   CHAIN           25..696
FT                   /note="Dipeptidyl-peptidase"
FT                   /evidence="ECO:0000256|RuleBase:RU366067"
FT                   /id="PRO_5023153613"
SQ   SEQUENCE   696 AA;  77038 MW;  09A3CB8911066CB5 CRC64;
     MSARQRILAL SVISVLSMGG AVFADEGMWV FDNLPLKALK QRYNFEPTPG WVERLRSSAV
     RFNSGGSGSF VSADGLVMTN HHVGADMLQK ISTAGKNYHK EGFLAKTRAD EIKAPDLELN
     VLVDIQDVTD RVLAAVKPGM GDSEAGTAKR KAMATIEKES LDKSGLRSDV VTLYQGGKYA
     LYTYKKYTDV RLVFAPEFDI AFFGGDPDNF EFPRYDLDVC FFRAYENDKP AQPKHYLNWS
     AAGSKDGDLI FVAGHPGKTS RLNTVAHLEY LRDVSFPFSL EILHDREAFL QEYGKKGPEQ
     ARQAMDELFG YQNSRKARAG GLKGLKDEAL MARKREAENA LRERIKADHA AQVAYGSAWD
     KIATAHQVST KIAKRYNFLE RGFAFDSSLF HIARTLVRLA QEQEKPNADR LREFRESAIE
     SLQLALFSDA PIYPEFEEAK LAHSLAFWKK WMGDIDPLVA RVLHGRTPEE VAKDFVQGTK
     LTDVSVRRDL AKGGLKALLE VDDPMIKLAL AVDADARTLR TQYEDEVEAV LSAQYAGIAK
     ATFEAQGDSV YPDATFTLRL AFGTVKGYEA GGKVIPPYTT IGGAFQHADA HGNTPPYVLP
     LSWHQAKKEG RLNLETAMNF VSTADIIGGN SGSPVVNRDN EVVGLIFDGN VDSLVLDFAF
     DDRSARAISV DSRAIYEALK SVYHADDLAK ELMDKP
//