ID L0H4J5_9HIV1 Unreviewed; 327 AA.
AC L0H4J5;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:AGA93175.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AGA93175.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AGA93175.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BCCFE_HOMER_GP41_4503 {ECO:0000313|EMBL:AGA93175.1};
RX PubMed=23055555; DOI=10.1128/JVI.01998-12;
RG the International HIV Adaptation Collaborative;
RA Carlson J.M., Brumme C.J., Martin E., Listgarten J., Brockman M.A.,
RA Le A.Q., Chui C.K., Cotton L.A., Knapp D.J., Riddler S.A., Haubrich R.,
RA Nelson G., Pfeifer N., Deziel C.E., Heckerman D., Apps R., Carrington M.,
RA Mallal S., Harrigan P.R., John M., Brumme Z.L.;
RT "Correlates of Protective Cellular Immunity Revealed by Analysis of
RT Population-Level Immune Escape Pathways in HIV-1.";
RL J. Virol. 86:13202-13216(2012).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; JX147080; AGA93175.1; -; Genomic_RNA.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR000328; GP41-like.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:AGA93175.1};
KW Virion {ECO:0000313|EMBL:AGA93175.1}.
FT TRANSMEM 168..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 20..209
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT REGION 209..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AGA93175.1"
FT NON_TER 327
FT /evidence="ECO:0000313|EMBL:AGA93175.1"
SQ SEQUENCE 327 AA; 37692 MW; 4DFDD3ABA490B624 CRC64;
AVGXIGAMFL GFLGAAGSTM GAASLTLTVQ ARQLLSGIVQ QQNNLLRAIE AQQHLLQLTV
WGIKQLQARV LAVERYLKDQ QLLGIWGCSG KLICTTTVPW NTSWSNKTMX QIWNNMTWMQ
WEREIDNYTS LIYTLIEXSQ NQQEKNEQEL LELDKWAXLW NWFDITHWLW YIKIFIMIVG
GLIGLRIVFA VLSIVNRVRQ GYSPLSFQTH FPAPRGPDRP EGIGEEGGXR DXXRSNRLVH
GFLALVWDDL RSLCLFXYHR LRDLLLIVXR TVEXLGRRGW EALKYWWNLL KYWSQELQNS
AVSLFNAXAI AVAXGTDRII EXXQRIF
//
