ID L0H4M8_9HIV1 Unreviewed; 326 AA.
AC L0H4M8;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:AGA93399.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AGA93399.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AGA93399.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BCCFE_HOMER_GP41_4727 {ECO:0000313|EMBL:AGA93399.1};
RX PubMed=23055555; DOI=10.1128/JVI.01998-12;
RG the International HIV Adaptation Collaborative;
RA Carlson J.M., Brumme C.J., Martin E., Listgarten J., Brockman M.A.,
RA Le A.Q., Chui C.K., Cotton L.A., Knapp D.J., Riddler S.A., Haubrich R.,
RA Nelson G., Pfeifer N., Deziel C.E., Heckerman D., Apps R., Carrington M.,
RA Mallal S., Harrigan P.R., John M., Brumme Z.L.;
RT "Correlates of Protective Cellular Immunity Revealed by Analysis of
RT Population-Level Immune Escape Pathways in HIV-1.";
RL J. Virol. 86:13202-13216(2012).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JX147304; AGA93399.1; -; Genomic_RNA.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR000328; GP41-like.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:AGA93399.1};
KW Virion {ECO:0000313|EMBL:AGA93399.1}.
FT TRANSMEM 167..194
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 19..208
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT REGION 207..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..232
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AGA93399.1"
FT NON_TER 326
FT /evidence="ECO:0000313|EMBL:AGA93399.1"
SQ SEQUENCE 326 AA; 37239 MW; 01E84D2DDB70BE98 CRC64;
AVGLGAXFLG FLGAAGSTMG AASVTLTVQA RLLLSGIVQQ QNNLLRAIEA QQHLLQLTVW
GIKQLQARXL AVERYLKDQQ LLGIWGCSGK LICTTAVPWN TSWSNKSLDR IWNNMTWXEX
EKEIDNYTSL IYTLIEESQN QQEKNEQELL ELDKWANLWN WFDIXNWLWY IKIFIMIVGG
LVGLRIVFTV LSIVNRVRKG YSPLSFQTRL PTPRGPDRPX GXEEEGGERD RDRSGPLVDG
FLAIIWVDLR NLCLFSYHRL RDLLLIVTRI VELLGRRGWE XLKYGWNLLX YWSQELKXSA
ISLLNATAIV VAEGTDRVIE XVRRAC
//
