GenomeNet

Database: UniProt
Entry: L0HD22_METFS
LinkDB: L0HD22_METFS
Original site: L0HD22_METFS 
ID   L0HD22_METFS            Unreviewed;       570 AA.
AC   L0HD22;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   25-OCT-2017, entry version 20.
DE   RecName: Full=Methyl-coenzyme M reductase subunit alpha {ECO:0000256|PIRNR:PIRNR000262};
DE            EC=2.8.4.1 {ECO:0000256|PIRNR:PIRNR000262};
GN   OrderedLocusNames=Metfor_0874 {ECO:0000313|EMBL:AGB01930.1};
OS   Methanoregula formicica (strain DSM 22288 / NBRC 105244 / SMSP).
OC   Archaea; Euryarchaeota; Methanomicrobia; Methanomicrobiales;
OC   Methanoregulaceae; Methanoregula.
OX   NCBI_TaxID=593750 {ECO:0000313|EMBL:AGB01930.1, ECO:0000313|Proteomes:UP000010824};
RN   [1] {ECO:0000313|Proteomes:UP000010824}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 22288 / NBRC 105244 / SMSP
RC   {ECO:0000313|Proteomes:UP000010824};
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Ovchinnikova G., Teshima H., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Imachi H.,
RA   Tamaki H., Sekiguchi Y., Kamagata Y., Cadillo-Quiroz H., Zinder S.,
RA   Liu W.-T., Woyke T.;
RT   "Complete sequence of Methanoregula formicicum SMSP.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Reduction of methyl-coenzyme M (2-(methylthio)
CC       ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate
CC       to methane and a heterodisulfide. {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- CATALYTIC ACTIVITY: Methyl-CoM + CoB = CoM-S-S-CoB + methane.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- COFACTOR:
CC       Name=coenzyme F430; Xref=ChEBI:CHEBI:60540;
CC         Evidence={ECO:0000256|PIRNR:PIRNR000262};
CC       Note=Binds 1 coenzyme F430 noncovalently per subunit. Coenzyme
CC       F430 is a yellow nickel porphinoid.
CC       {ECO:0000256|PIRNR:PIRNR000262};
CC   -!- PATHWAY: One-carbon metabolism; methyl-coenzyme M reduction;
CC       methane from methyl-coenzyme M: step 1/1.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- SUBUNIT: Hexamer of two alpha, two beta, and two gamma chains.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP003167; AGB01930.1; -; Genomic_DNA.
DR   EnsemblBacteria; AGB01930; AGB01930; Metfor_0874.
DR   KEGG; mfo:Metfor_0874; -.
DR   KO; K00399; -.
DR   OMA; QVWLGSY; -.
DR   OrthoDB; POG093Z00ZI; -.
DR   UniPathway; UPA00646; UER00699.
DR   Proteomes; UP000010824; Chromosome.
DR   GO; GO:0050524; F:coenzyme-B sulfoethylthiotransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.840.10; -; 1.
DR   Gene3D; 3.30.70.470; -; 1.
DR   Gene3D; 3.90.390.10; -; 1.
DR   InterPro; IPR016212; Me_CoM_Rdtase_asu.
DR   InterPro; IPR008924; Me_CoM_Rdtase_asu/bsu_C.
DR   InterPro; IPR009047; Me_CoM_Rdtase_asu_C.
DR   InterPro; IPR003183; Me_CoM_Rdtase_asu_N.
DR   InterPro; IPR015811; Me_CoM_Rdtase_asu_N_sub1.
DR   InterPro; IPR015823; Me_CoM_Rdtase_asu_N_sub2.
DR   InterPro; IPR009024; Me_CoM_Rdtase_Fd-like_fold.
DR   Pfam; PF02249; MCR_alpha; 1.
DR   Pfam; PF02745; MCR_alpha_N; 1.
DR   PIRSF; PIRSF000262; MCR_alpha; 1.
DR   SUPFAM; SSF48081; SSF48081; 1.
DR   SUPFAM; SSF55088; SSF55088; 1.
DR   TIGRFAMs; TIGR03256; met_CoM_red_alp; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000010824};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR000262,
KW   ECO:0000256|PIRSR:PIRSR000262-1};
KW   Methanogenesis {ECO:0000256|PIRNR:PIRNR000262};
KW   Nickel {ECO:0000256|PIRNR:PIRNR000262, ECO:0000256|PIRSR:PIRSR000262-
KW   1}; Reference proteome {ECO:0000313|Proteomes:UP000010824};
KW   Transferase {ECO:0000256|PIRNR:PIRNR000262}.
FT   DOMAIN       10    280       MCR_alpha_N. {ECO:0000259|Pfam:PF02745}.
FT   DOMAIN      328    461       MCR_alpha. {ECO:0000259|Pfam:PF02249}.
FT   METAL       159    159       Nickel. {ECO:0000256|PIRSR:PIRSR000262-
FT                                1}.
FT   MOD_RES     269    269       Pros-methylhistidine. {ECO:0000256|PIRSR:
FT                                PIRSR000262-2}.
FT   MOD_RES     283    283       5-methylarginine. {ECO:0000256|PIRSR:
FT                                PIRSR000262-2}.
SQ   SEQUENCE   570 AA;  62969 MW;  F00394A773F06758 CRC64;
     MQMASVEHSQ KQFLKALKEK FKGQDVESQK TGFYKFGGVQ QSPRKREFMA ATKKIEADRG
     ISMYDPEHCH LNGIPMGQRQ LMTYEVSGTG TFVEGDDLHY VNNSAIQQMS DEIKRTIIVG
     MDIAHNTLQK RLGKEVTPQT INEYLHILNH AMPGGAVVQE HMVETNPGLV DDCYVKIFTG
     NDEVADDIEP QYLLNIEKLF PKKQAEALKA EIGKSMYQAI HVPTIVVRTC DGGTTSRWSA
     MQIGMSFIAA YRTCAGEAAV ADLSFAAKHA GVIQMGSHLP ARRARGPNEP GGIKFGMFSD
     MIQADRKYPD DPAKASLEVV AAGAALFDQI WLGSYMSGGV GFTQYATAAY TDNILDDFTY
     YGMDYVKDKY GYNFRQPGAD KVIRPTQDIV NDIATEVTLY SMEQYEKFPT LMEDHFGGSQ
     RAAVMAAAAG LSTSITTGNS NAGLNAWYLS MIIHKDGWSR LGFFGYDLQD QCGSANSLSM
     EPDRGAMGEL RGPNYPNYAM NVGHQGEYAA IVASAHYGRA DAFCFDPRVK ITFADPSLKF
     DFSEPRKEFA RGAIREFEAA GERSLIMPAR
//
DBGET integrated database retrieval system