ID L0HGB2_METFS Unreviewed; 580 AA.
AC L0HGB2;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Pyruvate/oxaloacetate carboxyltransferase {ECO:0000313|EMBL:AGB02358.1};
GN OrderedLocusNames=Metfor_1318 {ECO:0000313|EMBL:AGB02358.1};
OS Methanoregula formicica (strain DSM 22288 / NBRC 105244 / SMSP).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanomicrobiales; Methanoregulaceae; Methanoregula.
OX NCBI_TaxID=593750 {ECO:0000313|EMBL:AGB02358.1, ECO:0000313|Proteomes:UP000010824};
RN [1] {ECO:0000313|Proteomes:UP000010824}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22288 / NBRC 105244 / SMSP
RC {ECO:0000313|Proteomes:UP000010824};
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Ovchinnikova G., Teshima H., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Imachi H.,
RA Tamaki H., Sekiguchi Y., Kamagata Y., Cadillo-Quiroz H., Zinder S.,
RA Liu W.-T., Woyke T.;
RT "Complete sequence of Methanoregula formicicum SMSP.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AGB02358.1, ECO:0000313|Proteomes:UP000010824}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22288 / NBRC 105244 / SMSP
RC {ECO:0000313|Proteomes:UP000010824};
RX PubMed=25189582;
RA Yamamoto K., Tamaki H., Cadillo-Quiroz H., Imachi H., Kyrpides N.,
RA Woyke T., Goodwin L., Zinder S.H., Kamagata Y., Liu W.T.;
RT "Complete Genome Sequence of Methanoregula formicica SMSPT, a Mesophilic
RT Hydrogenotrophic Methanogen Isolated from a Methanogenic Upflow Anaerobic
RT Sludge Blanket Reactor.";
RL Genome Announc. 2:e00870-14(2014).
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DR EMBL; CP003167; AGB02358.1; -; Genomic_DNA.
DR RefSeq; WP_015285321.1; NC_019943.1.
DR AlphaFoldDB; L0HGB2; -.
DR STRING; 593750.Metfor_1318; -.
DR GeneID; 14307707; -.
DR KEGG; mfo:Metfor_1318; -.
DR eggNOG; arCOG02095; Archaea.
DR HOGENOM; CLU_000395_4_2_2; -.
DR InParanoid; L0HGB2; -.
DR OrthoDB; 6555at2157; -.
DR Proteomes; UP000010824; Chromosome.
DR GO; GO:0004736; F:pyruvate carboxylase activity; IEA:UniProt.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR CDD; cd06850; biotinyl_domain; 1.
DR CDD; cd07937; DRE_TIM_PC_TC_5S; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR001882; Biotin_BS.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR003379; Carboxylase_cons_dom.
DR InterPro; IPR000891; PYR_CT.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR45266; OXALOACETATE DECARBOXYLASE ALPHA CHAIN; 1.
DR PANTHER; PTHR45266:SF3; OXALOACETATE DECARBOXYLASE ALPHA CHAIN; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF00682; HMGL-like; 1.
DR Pfam; PF02436; PYC_OADA; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR SUPFAM; SSF89000; post-HMGL domain-like; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS00188; BIOTIN; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS50991; PYR_CT; 1.
PE 4: Predicted;
KW Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Pyruvate {ECO:0000313|EMBL:AGB02358.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000010824};
KW Transferase {ECO:0000313|EMBL:AGB02358.1}.
FT DOMAIN 9..269
FT /note="Pyruvate carboxyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS50991"
FT DOMAIN 500..580
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
SQ SEQUENCE 580 AA; 63773 MW; 73CBB5280350FB05 CRC64;
MHPASPKKVL ITDTTLRDAH QSLIATRLRT EDMLPLAREI DSCGFFSVEA WGGATFDTCI
RFLNDDPWDR LRALKSELKH TPIQMLLRGQ NLVGYRHYPD DVVDKFVDAA HKNGVDIFRI
FDALNDIRNM TRSMKRVKDN GAHLQSTISY TTSPVHSTRS FIDMAKELYA LECDSICIKD
MAGLIMPEQA RELITGIKKA VDVKVCLHSH CTSGIAPMSY QAAISAGVDI LDTAMSPIAM
GTSQPPTESV VASLTGTSRD TGIDLIKLRA VRNQVLRIRD KYQGLLDPIS ERVDSDVLIY
QLPGGMISNI VSQLKEQDAL DRWDDVLAEV PRVREDLGYP PLVTPTSQIV GTQAVLNVLV
NGQRYRNVTK EVKDYVRGLY GKSPGSISDE IRTLIIGDEK VITQRPADLL EPSYDSMKAE
ATRAGLIKKE EDVLTYILYP AIAPSFLKGE RTIEEIPRKQ SAPTSPSDDI PSQMEVEVDG
EVFTVRIVSI GGNKVEVASA VPQKIPRGDI AGGIKSNMQG MVLKVPVSRG SAVKKGDTLV
ILEAMKMENP IHSPVDGKVT EIFVDAGDVV QNGDVLLVVQ
//
