GenomeNet

Database: UniProt
Entry: L0INK0_THETR
LinkDB: L0INK0_THETR
Original site: L0INK0_THETR 
ID   L0INK0_THETR            Unreviewed;       326 AA.
AC   L0INK0;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   24-JAN-2024, entry version 48.
DE   RecName: Full=lipoate--protein ligase {ECO:0000256|ARBA:ARBA00012367};
DE            EC=6.3.1.20 {ECO:0000256|ARBA:ARBA00012367};
GN   ORFNames=Thethe_01964 {ECO:0000313|EMBL:AGB19572.1};
OS   Thermoanaerobacterium thermosaccharolyticum M0795.
OC   Bacteria; Bacillota; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacteraceae; Thermoanaerobacterium.
OX   NCBI_TaxID=698948 {ECO:0000313|EMBL:AGB19572.1, ECO:0000313|Proteomes:UP000010845};
RN   [1] {ECO:0000313|EMBL:AGB19572.1, ECO:0000313|Proteomes:UP000010845}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M0795 {ECO:0000313|EMBL:AGB19572.1,
RC   ECO:0000313|Proteomes:UP000010845};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA   Kyrpides N., Ivanova N., Pagani I., Feinberg L., Folden J., Hogsett D.,
RA   Shaw J., Woyke T.;
RT   "Complete sequence of chromosome of Thermoanaerobacterium
RT   thermosaccharolyticum M0795.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein] = AMP +
CC         diphosphate + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier
CC         protein]; Xref=Rhea:RHEA:49288, Rhea:RHEA-COMP:10500, Rhea:RHEA-
CC         COMP:10502, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:83088, ChEBI:CHEBI:83099,
CC         ChEBI:CHEBI:456215; EC=6.3.1.20;
CC         Evidence={ECO:0000256|ARBA:ARBA00001121};
CC   -!- PATHWAY: Protein modification; protein lipoylation via exogenous
CC       pathway; protein N(6)-(lipoyl)lysine from lipoate: step 1/2.
CC       {ECO:0000256|ARBA:ARBA00005124}.
CC   -!- PATHWAY: Protein modification; protein lipoylation via exogenous
CC       pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.
CC       {ECO:0000256|ARBA:ARBA00005085}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP003066; AGB19572.1; -; Genomic_DNA.
DR   RefSeq; WP_015312072.1; NC_019970.1.
DR   AlphaFoldDB; L0INK0; -.
DR   KEGG; tto:Thethe_01964; -.
DR   PATRIC; fig|698948.3.peg.1962; -.
DR   HOGENOM; CLU_022986_0_2_9; -.
DR   UniPathway; UPA00537; UER00594.
DR   Proteomes; UP000010845; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016979; F:lipoate-protein ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR   CDD; cd16443; LplA; 1.
DR   Gene3D; 3.30.390.50; CO dehydrogenase flavoprotein, C-terminal domain; 1.
DR   InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR   InterPro; IPR004143; BPL_LPL_catalytic.
DR   InterPro; IPR019491; Lipoate_protein_ligase_C.
DR   InterPro; IPR004562; LipoylTrfase_LipoateP_Ligase.
DR   NCBIfam; TIGR00545; lipoyltrans; 1.
DR   PANTHER; PTHR12561; LIPOATE-PROTEIN LIGASE; 1.
DR   PANTHER; PTHR12561:SF3; LIPOYLTRANSFERASE 1, MITOCHONDRIAL; 1.
DR   Pfam; PF03099; BPL_LplA_LipB; 1.
DR   Pfam; PF10437; Lip_prot_lig_C; 1.
DR   SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR   SUPFAM; SSF82649; SufE/NifU; 1.
DR   PROSITE; PS51733; BPL_LPL_CATALYTIC; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:AGB19572.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Transferase {ECO:0000313|EMBL:AGB19572.1}.
FT   DOMAIN          24..211
FT                   /note="BPL/LPL catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS51733"
SQ   SEQUENCE   326 AA;  37509 MW;  0549BB94B7A80CFA CRC64;
     MIYIYNRITD PYFNLASEEY ILKEFKDDCF MLWRNEPSII VGKNQNTLAE INLDYVKEHK
     IPVVRRLSGG GAVFHDLGNV NFTFIVNDDL NGFSDFRRFT QPIIDVLKKL SINAEFSGRN
     DITIDGKKIS GNAQYYYKNR ILHHGTLLVS SNMTDLSAAL KVRPVKFEDK GVKSVSKRVT
     NINEHLKEPI DVEEFISLIM NDIREHTGGS GLYEFTDEDI RNIEKLKNEK YSTWEWNFGM
     SPDYNLKNEK KFLGGTLEVD LNVENGIIKD MKIYGDFFGK KDVKDIEEIL KGVKHSESGV
     REALSSVDIN EYFANISLEN LIDVLF
//
DBGET integrated database retrieval system