ID L0J4J1_9MYCO Unreviewed; 758 AA.
AC L0J4J1;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Putative RND superfamily drug exporter {ECO:0000313|EMBL:AGB25181.1};
DE Flags: Precursor;
GN ORFNames=Mycsm_04969 {ECO:0000313|EMBL:AGB25181.1};
OS Mycobacterium sp. JS623.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=212767 {ECO:0000313|EMBL:AGB25181.1, ECO:0000313|Proteomes:UP000010844};
RN [1] {ECO:0000313|Proteomes:UP000010844}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JS623 {ECO:0000313|Proteomes:UP000010844};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA Kyrpides N., Ivanova N., Pagani I., Mattes T., Holmes A., Rutledge P.,
RA Paulsen I., Coleman N., Woyke T.;
RT "Complete sequence of chromosome of Mycobacterium smegmatis JS623.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR EMBL; CP003078; AGB25181.1; -; Genomic_DNA.
DR RefSeq; WP_015308757.1; NC_019966.1.
DR AlphaFoldDB; L0J4J1; -.
DR STRING; 212767.Mycsm_04969; -.
DR KEGG; msa:Mycsm_04969; -.
DR PATRIC; fig|710686.3.peg.5005; -.
DR HOGENOM; CLU_005108_5_1_11; -.
DR OrthoDB; 7051771at2; -.
DR Proteomes; UP000010844; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 16..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 188..221
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 282..303
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 309..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 376..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 545..567
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 572..590
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 610..630
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 661..683
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 689..714
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 243..332
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 758 AA; 80030 MW; 1D0C5CB875BDB27D CRC64;
MLQRIALLAI AAPRRIIAIA LLVMVACGIF GIPVAKHLSA GGFQDPTSES AQATKLLVDK
FGQGDMELLI SVTSDVGAQG AAARAVGTNI ADQLKASPFV ANVTSAWTAP TSAAPALISR
DGKSGLIVAG ITGGESGAQQ HAKELTERLV HDRDGVTVRA GGEAMTYVQI NAQSEKDLLT
MESIAIPLSF IVLVWVFGGL ISAALPLAVG GFAILGSMAV LRAITLITDV SIFALNLTVA
MGLALAIDYT LLIISRYRDE LADGADRDRA LVRTMLTAGR TVLFSAMTVA LSMVAMVLFP
MYFLKSFAYA GIAVVVFAAV AAVVVAPAAI ALLGDRLDAL DARRLARWVF RRPDPVRNPI
EQTFWYRSTK RVIRQAVPIG VAIVALLLVL GAPFLGIKWG FPDERVLPQS LSARQVGDDL
RANFTVDSAR NVTVVVPNTT GVTPADMDSY ASALSQVSDV SSVSAPGGTF ADGRSVGPPS
AATGFKDGRA FLTVGSTAPL FSDASENQLD QLRAVPPPAG QHVELTGVAQ VNRDSSDAIT
SRLPMVLGII AVITFVLLFL LTGSVILPLK ALVLNVLSLT AAFGALVWIF QEGHLGALGT
TPTGTLVANM PVLLFCIAFG LSMDYEVFLV SRIREYWLKS GKTRADNDES VALGLARTGR
VVTAAAMLMA ISFAALIAAQ VAFMRMFGVG LTLAVIADAT LVRMLLLPAF MHVLGRWNWW
APKPLARLHE RIGISESHDD DAPVEKRDRI AAAVADTG
//
