ID   L0J4Z8_9MYCO            Unreviewed;      1891 AA.
AC   L0J4Z8;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   27-MAR-2024, entry version 63.
DE   SubName: Full=Amino acid adenylation enzyme/thioester reductase family protein {ECO:0000313|EMBL:AGB25697.1};
DE   Flags: Precursor;
GN   ORFNames=Mycsm_05508 {ECO:0000313|EMBL:AGB25697.1};
OS   Mycobacterium sp. JS623.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=212767 {ECO:0000313|EMBL:AGB25697.1, ECO:0000313|Proteomes:UP000010844};
RN   [1] {ECO:0000313|Proteomes:UP000010844}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JS623 {ECO:0000313|Proteomes:UP000010844};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA   Kyrpides N., Ivanova N., Pagani I., Mattes T., Holmes A., Rutledge P.,
RA   Paulsen I., Coleman N., Woyke T.;
RT   "Complete sequence of chromosome of Mycobacterium smegmatis JS623.";
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR   EMBL; CP003078; AGB25697.1; -; Genomic_DNA.
DR   RefSeq; WP_015309272.1; NC_019966.1.
DR   STRING; 212767.Mycsm_05508; -.
DR   KEGG; msa:Mycsm_05508; -.
DR   PATRIC; fig|710686.3.peg.5548; -.
DR   HOGENOM; CLU_000022_0_9_11; -.
DR   OrthoDB; 4501954at2; -.
DR   UniPathway; UPA00011; -.
DR   Proteomes; UP000010844; Chromosome.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR   GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR   CDD; cd05930; A_NRPS; 1.
DR   Gene3D; 3.30.300.30; -; 2.
DR   Gene3D; 3.40.50.980; -; 2.
DR   Gene3D; 1.10.1200.10; ACP-like; 2.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR020802; PKS_thioesterase.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR001031; Thioesterase.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR   PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 2.
DR   Pfam; PF13193; AMP-binding_C; 2.
DR   Pfam; PF00668; Condensation; 1.
DR   Pfam; PF00550; PP-binding; 2.
DR   Pfam; PF00975; Thioesterase; 1.
DR   SMART; SM00823; PKS_PP; 2.
DR   SMART; SM00824; PKS_TE; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR   SUPFAM; SSF47336; ACP-like; 2.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR   PROSITE; PS00455; AMP_BINDING; 2.
DR   PROSITE; PS50075; CARRIER; 2.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT   DOMAIN          508..582
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          1534..1609
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   REGION          1512..1538
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1891 AA;  205176 MW;  3814016BFBFFA16E CRC64;
     MLDFALDMTV DRLAADISGD RIAVVSESGT LRYSDFDAAV NHVAEVLRAK GVCRDDCVAV
     IVPRSPELLV AIHGILRAGA AYVPIDPEYP LLRIRTVIED CGARVVVART DFAEIVDELG
     ASRVEPTTAG ADLVEPVASP GDLAYVIYTS GSTGQPKGVM VEHRSVVNRL RWMQRQYPLD
     ADDVILQKTS VTFDVSVWEL LWWAMAGARV AMIEPGAERD PRKIVAAIQS HGVTVMHFVP
     SMLGSFLDQL ESQPDSIHRL TSLRMVFCSG EALTPALVER FNRVFGVIGV PQLVNLYGPT
     EATVDVSYFD CPSAGTVDVV PIGKPIDNTT LLVLDERRSP CPVGVAGELN IGGVCLARGY
     RGRPDLTADS FIDDQRVPGG RLYRTGDLAR WRSDGNLEFL GRIDDEVKVR GNRVSLGEVQ
     ATMESCPGVR SAVAIAEPSD NHGSNLIGYF VGDFVSLTAL RDHLARRLPG YMIPTSFVEL
     TELPLTTSGK VNRRALARPV TRDRSAVAPR TPAEAALVDV FGSVLNVDCV GVHDNFFTIG
     GDSILALAVR SEAEKRGIAF DIEELFARPT VAELAESNSR LTAAEPQGIT DSFAMLPLID
     RASLHDAEDA FPATGLQLGM LFHSIERAES TMYKDVFRYR VAMPWYEQQF TDAFDRLVQR
     HPALRSSFEL KQHSVPLQVV RSTVPRAFDA VIGASDVDVK DYMAAGHRKT YDISSGPLYS
     LRAFVREDGI DLAFAFHHAL LDGWSVVNLI GELLQDYLVS VGLDVRPINT EPYSSAILAE
     YVRAEMEALE NPAAQEFWRA ALSESCATSL ESYVVYEAPT TVPPIVTVLI PQWLEDAARK
     LATASDIPIK SLLLSVHCIA LQRISGEADV TTGVVTHGRP GRVGAEAAAG LFLNTIPIRL
     NGAQATCLET VEHIARFERA SHRYRRYPLQ AMQSDAGRTL FKTAFNFVNY HHFAALARAT
     GVELLDFESY EQTNFALLAT AGIDPRRGRL FLRVNGDPVS VTAAQAREYA IAFTGVLAEI
     VRSPDRALDV RANEVAAPDV TQLVAQQAAE EPDSVALVDD SRTWTYAELD GRADRIAAGL
     LAAGMPPGAR VGVMLDRSPE LIATVLGVLK AGAAVVPLDV SYPNARIDAM IRQARPFRVI
     SDISEVRQLV ETPEAGVLPA IDPNSAAYVL FTSGSTGAPK GVSMPHRALA NLITWQNRQT
     SGAVGSSTLQ FAPLSFDVSF QEIFSTLCGG GTLRLVSEAQ RKDSVALVRL VADEGIERVF
     LPFVALQAFA EAACSTCTWP ASLRVLISSG EQLRVTPEIR RLCTRLPGVL LENQYGPTET
     HVAASYPMTG SPDEFPMLPP IGTAIEGATL AVIGPDLRPL SPGNKGEICI GGRCVASGYE
     GQPDLTAERF VRVGDPPVTM YRTGDVGREL PSGDIVCLGR IDTQVKVRGF RVECAEVEIV
     IKRLYADVIR AAAVVARRLH TVDSVLVAYL VGDSDAVTAN GIRSRLRSVL PEHMIPDRFV
     WLDELPLTPS GKRDDKTLRE LPLSHDANET EGTPPRNGRE RAIADIMAEF AGAASFAADT
     NFFDAGGTSI GAMRVIMAIS RSWGVEIPLD AFVAAPTAAD LARLVTTGAV FRAFDPLVAL
     RSSGDRPPLF LIHPIGGNVL CYLNLAKHLP ADLPIYALQA AGAEPGAKPL RTMSDLAVSY
     IAAIRRVRPE GPYNIGGWSF GGYVAAEMAR QLADDELARL ILIDTIVLTD SPRPVIADRD
     LIIWFFMELL SQARGSDASK LVGRYDGMDC DALFDSFLGQ AIEAKIVPAE SSPQLIRRLY
     DIFHANYEAT MNYRHTRLDR DITLLKSTEQ LPTVAADVHR IVGSSFTSPT NGWERLMPRS
     LSVIDVAGDH LSMMSEPNVI DVASKLEAAL R
//