ID L0J6V9_9MYCO Unreviewed; 1801 AA.
AC L0J6V9;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Polyketide synthase family protein {ECO:0000313|EMBL:AGB26046.1};
GN ORFNames=Mycsm_05876 {ECO:0000313|EMBL:AGB26046.1};
OS Mycobacterium sp. JS623.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=212767 {ECO:0000313|EMBL:AGB26046.1, ECO:0000313|Proteomes:UP000010844};
RN [1] {ECO:0000313|Proteomes:UP000010844}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JS623 {ECO:0000313|Proteomes:UP000010844};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA Kyrpides N., Ivanova N., Pagani I., Mattes T., Holmes A., Rutledge P.,
RA Paulsen I., Coleman N., Woyke T.;
RT "Complete sequence of chromosome of Mycobacterium smegmatis JS623.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP003078; AGB26046.1; -; Genomic_DNA.
DR RefSeq; WP_015309621.1; NC_019966.1.
DR STRING; 212767.Mycsm_05876; -.
DR KEGG; msa:Mycsm_05876; -.
DR PATRIC; fig|710686.3.peg.5921; -.
DR HOGENOM; CLU_000022_35_5_11; -.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000010844; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd08955; KR_2_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 33..455
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1688..1763
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1779..1801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1787..1801
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1801 AA; 190357 MW; 949F59BD83E69A88 CRC64;
MAATAFSRIA AMTNAQRDAL VDQFGKASRL AAAEPVAVVG IGCRFPCDVV GPERYWTFLA
DGRDAVGEVP PDRWDADAYY DPDLAAPGRM ASKWGGFLRE IAEFDADFFG ISPREAEAMD
PQQRVLLEVA FEALEHAGIA TDHLGGIRAA VLMGVYYTEY QGISAANPDA IDAYCATGNA
HSITVGRIAY TLGLRGPAVA VDTACSSSLV SIHLACQSLR LRESDVALAG GVNLILRPET
QLALSKWGML SPRGRCRAFD AGADGFVRGE GAGVVVLKRL IDAVSDGDRV LAVVRGSAVN
QDGRSNGLTA PNALAQQDVI SRALQSADVT ASSVNLIETH GTGTALGDPI EFDALAAVYG
RGDGPCALGA VKTNFGHLEA AAGIAGFIKA VLALQRSRIP TNLHFTHWNP AIDPVPTRLF
VPTETTAWPQ CAGPRRAAVS SFGLGGTNAH VVLEQGPDPL SSSRDGESPA VTTLVVSGKT
SERLASTAAM LADWIEGDGS SVALSAVAET LNHRARYAIC ATVCGRDRGE AVDGLRALAA
GRSAPGVQER RGESRGPGIV FVYSGQGSQW AGMGRRLLAD EPSFAAAVAE LEPIFVAQCG
FSLQHVLQAG EPIAGIDHIQ PVLVGIHLAL TQLWRSYGVQ PDAVIGHSMG EVSAAIVSGA
LTVADGLRVI ATRSRLMARL SGQGAMALLE SDAPATEALI ADHPDVALAV YASPRQTVIA
GPPDEVDSLI AAVTAQNRLA RRIDVDVASH HPTIDPILPE LLGALADLDP VTPKIPLISA
TAPAGQPPAF DASYWVANVR NPVRFAQAVA VAAENHSTFI EISPHPLLTH ALTEAIESVR
PGGNGFVTGT LNRDDDETLT FHTQLVGVQT PTGSTGSRSR LADVPPTPWQ HQRYWLANRP
TGQMPTGAHL LLGMHVEMPS GHDHVWQADV GTDAVGWLAD HRVHGQPVMP AAGFAEIALA
AGSEALSLPP AGVAVTRLEV EQMLPLNGET RVTTQLTRSA DDEIRIEIHS RSTGGHWCRH
AVAQVEATQP SHRAVLANEE ADPGTEVAVG DFYSALRRTG AQHGPAFAAL TRIVRRDNGS
AETEIALPDT ATAHRGLRIH PVMLDAALQT LAAAMPAETL DASTEVTYLP VSIDRIQLLG
AVGRRGRCRA ELVSLDDDGA GKLGRITLMD ASGTPTAEIS GVYLRRVERR AVPLPLDQKI
FDTGWLECPT PARNDVLPAG SWLLLHNDSD SEALADAFAT RLGSPSMRVI TEDLFDEAAV
LEAFAKTASA PGLPPAGVVI LVGGHLFDGT AAPDALQRTR ELIWAISTTL RAVIGGWHGQ
SPRLWLVTRS GLAVTKDESG DPGIGALRGL VRVLAYEHPD LHTTLVDVGP ADDAVATVTT
ELQSPAADDV IAWRGGRRYV ERLRRAALSV AVHDPVVRRD GSYVVTGGLG GLGMVVARWL
VDRGAGRVVL NGRTPPSDAQ EADLADLRAH TEITFVAGDI ASPGVAEQLV CTAEENGLPL
RGVMHAAAVI EDALVATLNK ESLGRVWAPK AEGALRLHEA TAHRQLDWWA GFSSVASLLG
SPGQGAYACA NAWLDALVEW RRTSGLPAIA LNWGQWSEVG VARSLRFGVL DPISPAEGVA
ALDSLLGSDL VRVGITRLRL DRAAAAFPEI RKLGYFAEMV EELDAIDSGG DWPGVDALRE
LTPDDVDRIV TERLRQRISA IMGYPDQSAI PGTKPLTEIG MDSLMAVRIR NTLRDDFGVE
PAVALLLQGA SLGDLANELT QQLGLGSHDD ADRPNALRDR AHQRAAARQR AATRRKVGQR
V
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