ID L0L1V0_METHD Unreviewed; 107 AA.
AC L0L1V0;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Tetrahydromethanopterin S-methyltransferase subunit B {ECO:0000256|ARBA:ARBA00015127, ECO:0000256|HAMAP-Rule:MF_01094};
DE EC=2.1.1.86 {ECO:0000256|ARBA:ARBA00012514, ECO:0000256|HAMAP-Rule:MF_01094};
DE AltName: Full=N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit B {ECO:0000256|ARBA:ARBA00029818, ECO:0000256|HAMAP-Rule:MF_01094};
GN Name=mtrB {ECO:0000256|HAMAP-Rule:MF_01094};
GN OrderedLocusNames=Metho_2093 {ECO:0000313|EMBL:AGB50259.1};
OS Methanomethylovorans hollandica (strain DSM 15978 / NBRC 107637 / DMS1).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanomethylovorans.
OX NCBI_TaxID=867904 {ECO:0000313|EMBL:AGB50259.1, ECO:0000313|Proteomes:UP000010866};
RN [1] {ECO:0000313|Proteomes:UP000010866}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15978 / NBRC 107637 / DMS1
RC {ECO:0000313|Proteomes:UP000010866};
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Peters L., Mikhailova N., Held B.,
RA Kyrpides N., Mavromatis K., Ivanova N., Brettin T., Detter J.C., Han C.,
RA Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P.,
RA Woyke T., Wu D., Spring S., Schroeder M., Brambilla E., Klenk H.-P.,
RA Eisen J.A.;
RT "Complete sequence of chromosome of Methanomethylovorans hollandica DSM
RT 15978.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of a complex that catalyzes the formation of methyl-
CC coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-
CC tetrahydromethanopterin. This is an energy-conserving, sodium-ion
CC translocating step. {ECO:0000256|ARBA:ARBA00002533, ECO:0000256|HAMAP-
CC Rule:MF_01094}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2
CC Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2
CC Na(+)(out); Xref=Rhea:RHEA:53492, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:58103, ChEBI:CHEBI:58116, ChEBI:CHEBI:58286,
CC ChEBI:CHEBI:58319; EC=2.1.1.86;
CC Evidence={ECO:0000256|ARBA:ARBA00001816, ECO:0000256|HAMAP-
CC Rule:MF_01094};
CC -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); methyl-
CC coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step
CC 2/2. {ECO:0000256|ARBA:ARBA00004839, ECO:0000256|HAMAP-Rule:MF_01094}.
CC -!- SUBUNIT: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD,
CC MtrE, MtrF, MtrG and MtrH. {ECO:0000256|ARBA:ARBA00011616,
CC ECO:0000256|HAMAP-Rule:MF_01094}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162,
CC ECO:0000256|HAMAP-Rule:MF_01094}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004162, ECO:0000256|HAMAP-Rule:MF_01094}.
CC Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the MtrB family. {ECO:0000256|ARBA:ARBA00010027,
CC ECO:0000256|HAMAP-Rule:MF_01094}.
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DR EMBL; CP003362; AGB50259.1; -; Genomic_DNA.
DR RefSeq; WP_015325424.1; NC_019977.1.
DR AlphaFoldDB; L0L1V0; -.
DR STRING; 867904.Metho_2093; -.
DR GeneID; 14406606; -.
DR KEGG; mhz:Metho_2093; -.
DR HOGENOM; CLU_171544_1_0_2; -.
DR OrthoDB; 114034at2157; -.
DR UniPathway; UPA00640; UER00698.
DR Proteomes; UP000010866; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030269; F:tetrahydromethanopterin S-methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01094; MtrB; 1.
DR InterPro; IPR008690; MtrB_MeTrfase.
DR NCBIfam; TIGR04166; methano_MtrB; 1.
DR Pfam; PF05440; MtrB; 1.
DR PIRSF; PIRSF005518; MtrB; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_01094};
KW Membrane {ECO:0000256|HAMAP-Rule:MF_01094};
KW Methanogenesis {ECO:0000256|HAMAP-Rule:MF_01094};
KW Methyltransferase {ECO:0000256|HAMAP-Rule:MF_01094,
KW ECO:0000313|EMBL:AGB50259.1};
KW One-carbon metabolism {ECO:0000256|HAMAP-Rule:MF_01094};
KW Reference proteome {ECO:0000313|Proteomes:UP000010866};
KW Transferase {ECO:0000256|HAMAP-Rule:MF_01094, ECO:0000313|EMBL:AGB50259.1};
KW Transmembrane {ECO:0000256|HAMAP-Rule:MF_01094};
KW Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_01094}.
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01094"
SQ SEQUENCE 107 AA; 11678 MW; C220F618E6114C70 CRC64;
MSMIHVAPEA HLVLDPLTSL LAEERPDIIQ YSMDPILAKI DELDKIADDL VNSLAPDRPL
MNSFPGRENT SYIAGIYGNS FYGIIVGLGV AGLLLIVMYV LKTMGVM
//
