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Database: UniProt
Entry: L0MI02_SERMA
LinkDB: L0MI02_SERMA
Original site: L0MI02_SERMA 
ID   L0MI02_SERMA            Unreviewed;       235 AA.
AC   L0MI02;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   05-JUL-2017, entry version 39.
DE   RecName: Full=DnaA regulatory inactivator Hda {ECO:0000256|HAMAP-Rule:MF_01158, ECO:0000256|SAAS:SAAS00634471};
GN   Name=hda {ECO:0000256|HAMAP-Rule:MF_01158};
GN   ORFNames=D781_3289 {ECO:0000313|EMBL:AGB83513.1};
OS   Serratia marcescens FGI94.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Serratia.
OX   NCBI_TaxID=1249634 {ECO:0000313|EMBL:AGB83513.1, ECO:0000313|Proteomes:UP000011001};
RN   [1] {ECO:0000313|EMBL:AGB83513.1, ECO:0000313|Proteomes:UP000011001}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGI94 {ECO:0000313|EMBL:AGB83513.1,
RC   ECO:0000313|Proteomes:UP000011001};
RX   PubMed=23516234;
RA   Aylward F.O., Tremmel D.M., Starrett G.J., Bruce D.C., Chain P.,
RA   Chen A., Davenport K.W., Detter C., Han C.S., Han J., Huntemann M.,
RA   Ivanova N.N., Kyrpides N.C., Markowitz V., Mavrommatis K., Nolan M.,
RA   Pagani I., Pati A., Pitluck S., Teshima H., Deshpande S., Goodwin L.,
RA   Woyke T., Currie C.R.;
RT   "Complete Genome of Serratia sp. Strain FGI 94, a Strain Associated
RT   with Leaf-Cutter Ant Fungus Gardens.";
RL   Genome Announc. 1:E0023912-E0023912(2013).
CC   -!- FUNCTION: Mediates the interaction of DNA replication inititator
CC       protein DnaA with DNA polymerase subunit beta sliding clamp
CC       (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering
CC       DnaA inactive for reinititation, a process called regulatory
CC       inhibition of DnaA or RIDA. {ECO:0000256|HAMAP-Rule:MF_01158}.
CC   -!- SUBUNIT: The active form seems to be an ADP-bound monomer. Forms
CC       the RIDA complex (regulatory inactivation of DnaA) of ATP-DnaA,
CC       ADP-Hda and the DNA-loaded beta sliding clamp (dnaN).
CC       {ECO:0000256|HAMAP-Rule:MF_01158}.
CC   -!- SIMILARITY: Belongs to the DnaA family. HdA subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_01158, ECO:0000256|SAAS:SAAS00548763}.
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DR   EMBL; CP003942; AGB83513.1; -; Genomic_DNA.
DR   RefSeq; WP_015673342.1; NC_020064.1.
DR   EnsemblBacteria; AGB83513; AGB83513; D781_3289.
DR   GeneID; 32372551; -.
DR   KEGG; smaf:D781_3289; -.
DR   PATRIC; fig|1249634.3.peg.3161; -.
DR   KO; K10763; -.
DR   OrthoDB; POG091H0GIW; -.
DR   Proteomes; UP000011001; Chromosome.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-HAMAP.
DR   GO; GO:0032297; P:negative regulation of DNA-dependent DNA replication initiation; IEA:InterPro.
DR   HAMAP; MF_01158; Hda; 1.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR017788; Hda.
DR   InterPro; IPR022864; Hda_Enterobact.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   PRINTS; PR00051; DNAA.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR03420; DnaA_homol_Hda; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000011001};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_01158,
KW   ECO:0000256|SAAS:SAAS00634466};
KW   DNA replication inhibitor {ECO:0000256|HAMAP-Rule:MF_01158,
KW   ECO:0000256|SAAS:SAAS00634468}.
FT   DOMAIN       18    214       Bac_DnaA. {ECO:0000259|Pfam:PF00308}.
SQ   SEQUENCE   235 AA;  26747 MW;  314C14DC7843E710 CRC64;
     MLLNTPAQLS LPLYLPDDET FASFYPGENP SLLAAIQSAV SQEHGSYIYF WSREGGGRSH
     LLHAACAEMS QRGEAAGYVP LDKRAYFVPE VLDGMEQLAL VCIDNIECIA GDEEWEMAIF
     NLYNRILETG RTRLFITGDR PPRQLNLQLP DLASRLDWGQ IYKLQPLSDD EKLQALQLRA
     KLRGFELPED VGRFLLKRLD REMRTLFMTL DQLDRASITA QRKLTIPFVK EILGL
//
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