ID L1L821_9ACTN Unreviewed; 749 AA.
AC L1L821;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=MMPL family protein {ECO:0000313|EMBL:EKX68825.1};
GN ORFNames=STRIP9103_03868 {ECO:0000313|EMBL:EKX68825.1};
OS Streptomyces ipomoeae 91-03.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=698759 {ECO:0000313|EMBL:EKX68825.1, ECO:0000313|Proteomes:UP000010411};
RN [1] {ECO:0000313|EMBL:EKX68825.1, ECO:0000313|Proteomes:UP000010411}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91-03 {ECO:0000313|EMBL:EKX68825.1,
RC ECO:0000313|Proteomes:UP000010411};
RA Huguet-Tapia J.C., Durkin A.S., Pettis G.S., Badger J.H.;
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKX68825.1}.
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DR EMBL; AEJC01000056; EKX68825.1; -; Genomic_DNA.
DR RefSeq; WP_009297327.1; NZ_AEJC01000056.1.
DR AlphaFoldDB; L1L821; -.
DR PATRIC; fig|698759.3.peg.591; -.
DR OrthoDB; 7051771at2; -.
DR Proteomes; UP000010411; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000010411};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 179..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 203..221
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 274..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 377..396
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 533..552
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 564..585
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 597..616
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 645..664
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 676..701
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 196..328
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 339..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 727..749
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 749 AA; 77836 MW; D7CA8FDB64C6E024 CRC64;
MATFLYKLGR LAFRRRHFVA LIWVALLTLA GVGAASAPSA GTTSFSIPGT EAQKAFDLLD
ERFPGTSADG ATARVVFKAP SGEKMTDADN KATVEATVKE LSHGSEVVSV ADPYTANAVS
RDGTVAYASV SYKVAGPELK DSTRDALDEA AQQARDAGLT VEVGGDALQT VAEAGAGEVV
GIAIAAIVLV ITLGSLVAAG LPLLTAIIGV GIGVSVITAL ASTLELGSTT STLAVMIGLA
VGIDYALFIV SRYRSELAEG REREEAAGRA TGTAGSAVVF AGLTVVIALA GLSVVNVPML
TKMGLAAAGT VVIAVLIALT MIPALLGYAG RKVQPTGEKS KLFGRRKKAA EGSGSPETAA
RPNMGTRWAS FVVRRPVAVL LLGVVGLGAL AVPVTSMELG LPDDGTQPTS TTQRRAYDIL
SEGFGPGFNG PLMIVGDAKA SDDPQAAATA VADKIKGLDD VAAVAPAQLN KAGDTFIITV
IPGSKPASTQ TEDLVHAIRD TGADIKADTD AEVFVTGQTA MNIDFSQRMN DALVPYLSLV
VGLAFLLLIL VFRSILVPLK AALGFLLSVL AALGAVVAVF QWGWLSGLLG VEETGPIMSM
MPIFMIGVVF GLAMDYEVFL VTRMREAYVH GEKPSQAVVT GFKHGARVVT AAAIIMMAVF
AGFITSSESM VKMIGFGLAV AVFFDAFVVR MAIVPAVLAL LGKKAWWLPK WLDRALPNVD
VEGEGLRTLD ADEPKRSDED DEEKELVRA
//
