ID L1LCJ2_THEEQ Unreviewed; 2566 AA.
AC L1LCJ2;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Cytosol aminopeptidase family, catalytic domain containing family {ECO:0000313|EMBL:EKX73061.1};
DE EC=3.4.11.1 {ECO:0000313|EMBL:EKX73061.1};
GN ORFNames=BEWA_016220 {ECO:0000313|EMBL:EKX73061.1};
OS Theileria equi strain WA.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Theileriidae; Theileria.
OX NCBI_TaxID=1537102 {ECO:0000313|EMBL:EKX73061.1, ECO:0000313|Proteomes:UP000031512};
RN [1] {ECO:0000313|EMBL:EKX73061.1, ECO:0000313|Proteomes:UP000031512}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WA {ECO:0000313|EMBL:EKX73061.1,
RC ECO:0000313|Proteomes:UP000031512};
RX PubMed=23137308; DOI=10.1186/1471-2164-13-603;
RA Kappmeyer L.S., Thiagarajan M., Herndon D.R., Ramsay J.D., Caler E.,
RA Djikeng A., Gillespie J.J., Lau A.O., Roalson E.H., Silva J.C., Silva M.G.,
RA Suarez C.E., Ueti M.W., Nene V.M., Mealey R.H., Knowles D.P., Brayton K.A.;
RT "Comparative genomic analysis and phylogenetic position of Theileria
RT equi.";
RL BMC Genomics 13:603-603(2012).
CC -!- SIMILARITY: Belongs to the peptidase M17 family.
CC {ECO:0000256|ARBA:ARBA00009528}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKX73061.1}.
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DR EMBL; ACOU01000004; EKX73061.1; -; Genomic_DNA.
DR STRING; 1537102.L1LCJ2; -.
DR MEROPS; M17.008; -.
DR EnsemblProtists; EKX73061; EKX73061; BEWA_016220.
DR VEuPathDB; PiroplasmaDB:BEWA_016220; -.
DR eggNOG; KOG2597; Eukaryota.
DR OrthoDB; 2899215at2759; -.
DR Proteomes; UP000031512; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR011356; Leucine_aapep/pepB.
DR InterPro; IPR000819; Peptidase_M17_C.
DR PANTHER; PTHR11963; LEUCINE AMINOPEPTIDASE-RELATED; 1.
DR PANTHER; PTHR11963:SF23; ZGC:152830; 1.
DR Pfam; PF00883; Peptidase_M17; 1.
DR PRINTS; PR00481; LAMNOPPTDASE.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000256|ARBA:ARBA00022438,
KW ECO:0000313|EMBL:EKX73061.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:EKX73061.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000031512};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 61..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 85..102
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 146..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 269..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1442..1463
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1475..1495
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1937..2118
FT /note="Cytosol aminopeptidase"
FT /evidence="ECO:0000259|Pfam:PF00883"
FT REGION 2339..2363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2346..2363
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2566 AA; 289098 MW; 31EC55A920AF7915 CRC64;
MAKEEERRDG LFFDSLTYFL VGLSVALIYS FADNDHFMFY KVFREAGIHV DFPHYYTRQL
VVFWGFVASF TFMFVGVFNK KICTFVGWLV PLSYLYIISK VTEYGSVKFG TGMLRAIAVT
SIVSHIFQTC FVFQIFEETE GLFQRLLSFV GGYFLGYPVV TRLLLRRVLV DGMMDSASIG
DDLFHFCTTL FFITFTMAAC LTYLFYGMTG GMNTHYWLPA FSPSMGDKIS LGTCVYLWIL
NPVCISILPQ TLMEQSEYHN HVFIQRVTFA IALLAIPSVV GSMDVSMRCI LTLWKKRTLR
YLEGLKAAIM VSEELNEMVE EDGREESPLS IVYNSSDIKV PSHIDTWSSI NCDSFSDWEH
RDVETRDSIL SAILILDLLI KLENTLELGL VEDILKLYCS SKTKDPLVTC TVLLTDNKQV
LLTVLSRSMG MSKGLLTQVE KIPNCYNGGF GDSTKRCCFK KGVCKGTSLA GTTSNEGTEN
KTCDCCCPVS IAEIRDFVRE SVSSTEDSIC TMVTRINADT ILSSMEASDL TLDSAKVCVA
VLKAYYQSCI WLLISILCIE EAILLAVWFC KLCELCKNIC KIIDEKTPKC QCINKSKEGT
AVTIKTCSVT TLENFDDCDC LCIVSYYGIR TSVETIMTRL HCLRTELVTR ANTTCTFQKV
ETSDLASEAY LLDSIKAAII LFFGLDSVYK FIVETFKDAC WCCHKDKDPL YPAILSCLLV
CYRLCSRLFR DASEGTKILE DALLWYKCIF AAKKSSIANV PTKNVENKVE EVKGDKEVKT
EDCEGGAVAK TRNLKLTITS FETFVKSAQT SLSYFYRTNN RDGEGYAVYY AINVDKTKKA
VKYLSRLAMT DQKNYTLSSK NLVLREGMSK SGFSSGSCVN IIEDKAKLED QKKESPCKCF
SSEGEDICAS CEKGEQCNGC KNCECKCKCP ENEGCPCGKT QDKSCKDNVF TRLSQIIECK
CGTEEKEKKC SNCFNKLCSS LSNLTNKISE VSGSKKEEEK KECEHPGKCG GICCQTRRFS
HFLKTYVISV FRDIYKELNC KEIKCKCCPC CKKNGELFKC KCQCKEDKKE KECGCKCNCS
DTEGCSSEGA ECKCECRCEL CWKNFFRCFV ICGLKCGDQC KSEGKGCCKC CCTKTGQEQC
KCENSHKDDG KCTHKCENCL LCLYTTNMFF CSKCCSQQSE TECKKSAISC KCTCGTGTDK
CCCKEIAEDK KKEGELASLK LDCCCGDRLG CSIDKITCLL KCFETELPGL YCLASKLDCQ
LFQFCEQLCS VLDTLEDVKF VLEKAIKIVE CRITKVKCMI KCYSAKFKSL KEQIESIDKK
DEMYPQVVDL VKKTGKFAVL VTSYSPEIEA TYMKTDFHSE LLKSTTQNLA EVAMRVEDTS
QLAASTGRSR VALLADSKTV QVDAPNKSEK DNSSILKEYI FIVCRIIFLL LRFQILDPNR
LWLVKVFTVA FSILSAVYLN LFITELSSDL GKHTGYSINL ILLCGVGTNF IYSWLFHLFD
YVSIVYPFGN IVSKLETSNP SVDYGKSRYS MFISLISSLR TEFNSIFGIF SDLDTTSSYS
GIRQNVYPFS TMSKSLISSF RGTLDFTPIL NGPNRSVSAI MDHISFTLLG CHSDDLLTKS
SGYFGDLNRE MLWHSWYANT VITDTTLFYY YLRRSILFEM SEIARLRPVD KPFSRGFTNS
RQLWKHFGKI QVDLSFNASL KSPEIEIPRS RHQLNLLRER LYQEYRQKWL VYQLRATKSL
VNVPLDEHSS TEDLPFLYIK ELDTVHLTAN SLDKLDKKYS DVYRGTKINN CKVLKKEIKT
WRSSKLGFCE TLSDEGECKR AVNTAVKSLE RFFDTCEDHK PVKDMIEYIT STDYYSTYTH
GDSDLDTDHK MALFDLTFHQ DGLENNYRIF KGFKNSISHT LDHQLEIAKR NKTTSLIPLG
IYTLHYGLQI SHNTLEQIEK GLALEFKVLE KDECEELGMG AYLAVSQGSV HPPKFLHATY
KSDGDIKKKI AFVGKGIMFD AGGYNVKNAT TMIHLMKLDM GGMATVFGAA EAIAKLKPKH
VEVHFISATC ENMVDANSYR PGDIVTASNG KTIEVINTDC EGRMTLADAL CYAESLGVDV
VLDTATLTGA QIVALGGDNV QQDENGYFYN SDDGQVNLTE DWYPDPEGIY RKFTHTPKGG
SIKEILHKGS ALSGINLSSH TSVSVYYWTL DTDYSQPLLI QLGEGINEYY IRSNDDNWTK
YHDSNSLQKD LDKQNCTRNR AHIVLISDKS DGYQCPGCDT QKINVLTSSP SGYNSHRHSI
GYSSSISVTT FKDDKNGQVG LPPVKDAQYV IVYRRKSGDT NPLLIYYKQD EEKWFRRNTS
DGNTWSEVSK DKKPTNPNED TDGKIKDLLQ LSEYHPQITL DLSTSATNYS DSNTGIHITV
RSSPVEGGYS EFEHSLFGGL FTVKSVMHGT TPLTGITSDG QLDSVTAYYY GDHPSEEKRL
LLVELRSRGG IKYQYFHRET KDAKDWKEYS ISDQESTRLQ GKYLKTELDK LKKVQFPSGK
STLRKVLEGC GETGAAGGVG AEAYNFFFNP DKSATRQIIR LLTRLL
//
