ID L1MMY5_9BACT Unreviewed; 1308 AA.
AC L1MMY5;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Beta-galactosidase {ECO:0000256|ARBA:ARBA00012756, ECO:0000256|RuleBase:RU361154};
DE EC=3.2.1.23 {ECO:0000256|ARBA:ARBA00012756, ECO:0000256|RuleBase:RU361154};
DE AltName: Full=Lactase {ECO:0000256|ARBA:ARBA00032230, ECO:0000256|RuleBase:RU361154};
GN ORFNames=HMPREF9999_00682 {ECO:0000313|EMBL:EKX92623.1};
OS Alloprevotella sp. oral taxon 473 str. F0040.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC Alloprevotella.
OX NCBI_TaxID=1035197 {ECO:0000313|EMBL:EKX92623.1, ECO:0000313|Proteomes:UP000010460};
RN [1] {ECO:0000313|EMBL:EKX92623.1, ECO:0000313|Proteomes:UP000010460}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0040 {ECO:0000313|EMBL:EKX92623.1,
RC ECO:0000313|Proteomes:UP000010460};
RA Weinstock G., Sodergren E., Lobos E.A., Fulton L., Fulton R., Courtney L.,
RA Fronick C., O'Laughlin M., Godfrey J., Wilson R.M., Miner T., Farmer C.,
RA Delehaunty K., Cordes M., Minx P., Tomlinson C., Chen J., Wollam A.,
RA Pepin K.H., Bhonagiri V., Zhang X., Suruliraj S., Warren W., Mitreva M.,
RA Mardis E.R., Wilson R.K.;
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC in beta-D-galactosides.; EC=3.2.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001412,
CC ECO:0000256|RuleBase:RU361154};
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC {ECO:0000256|ARBA:ARBA00007401, ECO:0000256|RuleBase:RU361154}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKX92623.1}.
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DR EMBL; AMEK01000042; EKX92623.1; -; Genomic_DNA.
DR RefSeq; WP_009436639.1; NZ_KB290710.1.
DR STRING; 1035197.HMPREF9999_00682; -.
DR PATRIC; fig|1035197.3.peg.560; -.
DR eggNOG; COG3250; Bacteria.
DR HOGENOM; CLU_002346_0_2_10; -.
DR OrthoDB; 9801077at2; -.
DR Proteomes; UP000010460; Unassembled WGS sequence.
DR GO; GO:0009341; C:beta-galactosidase complex; IEA:InterPro.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 2.70.98.10; -; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR004199; B-gal_small/dom_5.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR014718; GH-type_carb-bd.
DR InterPro; IPR006101; Glyco_hydro_2.
DR InterPro; IPR023232; Glyco_hydro_2_AS.
DR InterPro; IPR006103; Glyco_hydro_2_cat.
DR InterPro; IPR023230; Glyco_hydro_2_CS.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR006104; Glyco_hydro_2_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR032312; LacZ_4.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR PANTHER; PTHR46323; BETA-GALACTOSIDASE; 1.
DR PANTHER; PTHR46323:SF2; BETA-GALACTOSIDASE; 1.
DR Pfam; PF02929; Bgal_small_N; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF02836; Glyco_hydro_2_C; 1.
DR Pfam; PF02837; Glyco_hydro_2_N; 1.
DR Pfam; PF16353; LacZ_4; 1.
DR Pfam; PF14200; RicinB_lectin_2; 1.
DR PRINTS; PR00132; GLHYDRLASE2.
DR SMART; SM01038; Bgal_small_N; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 2.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF50370; Ricin B-like lectins; 1.
DR PROSITE; PS00719; GLYCOSYL_HYDROL_F2_1; 1.
DR PROSITE; PS00608; GLYCOSYL_HYDROL_F2_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361154};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361154};
KW Reference proteome {ECO:0000313|Proteomes:UP000010460};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..1308
FT /note="Beta-galactosidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003954304"
FT DOMAIN 943..1214
FT /note="Beta galactosidase small chain/"
FT /evidence="ECO:0000259|SMART:SM01038"
SQ SEQUENCE 1308 AA; 147337 MW; 0B87BB86AC965606 CRC64;
MKTKTFSSLL TLVAIGVLWC CGALSASAKL EAERYYTLTN VHHGMTLSTG GVGAKDSPLV
GEAYKKGSPD QLWQLKASGS DAFALYNPES NLAVDLAIQA KKNPLLWSLD VNNPNQQLIL
EEEGTNFRLR AASFQFEARY LSITRDGKVL LDSNKNNNSL FKFTEVNLKD IQYPDRAEWE
NEMIFGINKE RGRATFIPYA TTAQLQADAR YKKAWLDPEQ GQFLSLNGMW KFKYAPDAAK
RDTAFVKTTF DVSKWDNIEV PSCWEMKGYD KPVYVNVDYI FADKPPYIKL RNEYKGLVDP
NPVGSYRRTF TLPTNWDKKN VFLHFDGIYS GAYVWVNGKY IGYTEGGNND AEFDITKAVK
AGENQVAVQV IRWTDASYLE GQDAFHMSGL HRDVYLVATP QTFVRDHVIT AQLEASKSYT
AGVMEVNLEL DNRHKLSGKK QIKVSLLDAD NKVVKTATTE VQYTAATEKV MAKVNLDGLT
NLQPWTAETP YLYNVLVSQQ DEKGNEEMVF NTKYGFRHIE IKQGLVRING KRVFFKGVNT
QDTHPEKGRT MDVPTMLRDI FLMKQANVNT VRTSHYPRQP KMYAMFDYYG LYIMDEADIE
CHKNWNDHGA NGGYNTQVIS GRTSWKPMMV DRTERMVLRD RNHPSIVFWS LGNESGAGDN
FIATYNAARA LDARPIHYEG ATNAGRHTAG LTDINSKMYP DIDFTRRAAN KQGSNTAGQP
FFMCEYNHAM GNSMGYLREY WDVLESSSVG IGGCIWDWVD QGIYNPQLLK KGERRLTTGY
DYPGPHQGNF VNNGVITSER EWTPKLTELK KVYQYVRISY NNKTKQLSVT NRYAFRTLQG
FSLHYSVLRD GESVETGTLD LPALDPQRAH HFPLSLKTAI DNKADYHLNV EMRTTVDEDW
AKSGYVQAAE QFVLAQRTAL PALPAVKGDV KRLKVDRKNN QVIVSNDRVS MTFDENTAEL
VAWSYNGQPI LYPGKGAKYD NFRWIENEAP YTSKPYKELG SGHQVPDLFN FGSAPEVTTQ
QNGQKVIVTA MNEGNVPNPL TYTIHADGTV LLDASFSYNS GKLRRLGVSM GFDRKYNNLD
YTAKGPQENY VDRQEGSFFG RYKTVVDSNI VNYARTQTCG NRMSLRRLDL TDNEGNGFRV
ETQGQVDFSI LPYDDHDLVA VEHWWELKKP VYNTAHFDAF QQGLGSGSCG PAETLDKYKA
FKQDMPMKYT LRFTPLGGLI TGISSPSLSA STAALQLSQP DSSTVVVKGD LTPYHQAQLV
NLGGVILQSL PLSGSNNLRF SVADLAEGTY LLHLQQTDGT STTLKFFH
//
