ID L1NQJ5_9FLAO Unreviewed; 520 AA.
AC L1NQJ5;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Galactose-1-phosphate uridylyltransferase {ECO:0000256|HAMAP-Rule:MF_00571};
DE Short=Gal-1-P uridylyltransferase {ECO:0000256|HAMAP-Rule:MF_00571};
DE EC=2.7.7.12 {ECO:0000256|HAMAP-Rule:MF_00571};
DE AltName: Full=UDP-glucose--hexose-1-phosphate uridylyltransferase {ECO:0000256|HAMAP-Rule:MF_00571};
GN Name=galT {ECO:0000256|HAMAP-Rule:MF_00571};
GN ORFNames=HMPREF9078_01743 {ECO:0000313|EMBL:EKY05621.1};
OS Capnocytophaga sp. oral taxon 380 str. F0488.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Capnocytophaga.
OX NCBI_TaxID=1127693 {ECO:0000313|EMBL:EKY05621.1, ECO:0000313|Proteomes:UP000010436};
RN [1] {ECO:0000313|EMBL:EKY05621.1, ECO:0000313|Proteomes:UP000010436}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0488 {ECO:0000313|EMBL:EKY05621.1,
RC ECO:0000313|Proteomes:UP000010436};
RA Weinstock G., Sodergren E., Lobos E.A., Fulton L., Fulton R., Courtney L.,
RA Fronick C., O'Laughlin M., Godfrey J., Wilson R.M., Miner T., Farmer C.,
RA Delehaunty K., Cordes M., Minx P., Tomlinson C., Chen J., Wollam A.,
RA Pepin K.H., Bhonagiri V., Zhang X., Suruliraj S., Warren W., Mitreva M.,
RA Mardis E.R., Wilson R.K.;
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-
CC glucose 1-phosphate + UDP-alpha-D-galactose; Xref=Rhea:RHEA:13989,
CC ChEBI:CHEBI:58336, ChEBI:CHEBI:58601, ChEBI:CHEBI:58885,
CC ChEBI:CHEBI:66914; EC=2.7.7.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001107, ECO:0000256|HAMAP-
CC Rule:MF_00571};
CC -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC {ECO:0000256|ARBA:ARBA00004947, ECO:0000256|HAMAP-Rule:MF_00571}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|HAMAP-Rule:MF_00571}.
CC -!- SIMILARITY: Belongs to the galactose-1-phosphate uridylyltransferase
CC type 2 family. {ECO:0000256|ARBA:ARBA00008706, ECO:0000256|HAMAP-
CC Rule:MF_00571}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKY05621.1}.
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DR EMBL; AMES01000139; EKY05621.1; -; Genomic_DNA.
DR RefSeq; WP_009420682.1; NZ_KB291241.1.
DR AlphaFoldDB; L1NQJ5; -.
DR PATRIC; fig|1127693.3.peg.1586; -.
DR HOGENOM; CLU_047799_0_0_10; -.
DR UniPathway; UPA00214; -.
DR Proteomes; UP000010436; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008108; F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00571; GalP_UDP_trans; 1.
DR InterPro; IPR000766; GalP_uridyl_Trfase_II.
DR InterPro; IPR023425; GalP_uridyl_Trfase_II_CS.
DR InterPro; IPR005850; GalP_Utransf_C.
DR InterPro; IPR005849; GalP_Utransf_N.
DR PANTHER; PTHR39191:SF1; DUF4922 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR39191; GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; 1.
DR Pfam; PF02744; GalP_UDP_tr_C; 1.
DR Pfam; PF01087; GalP_UDP_transf; 1.
DR PIRSF; PIRSF006005; GalT_BS; 1.
DR PROSITE; PS01163; GAL_P_UDP_TRANSF_II; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277, ECO:0000256|HAMAP-
KW Rule:MF_00571};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00571};
KW Galactose metabolism {ECO:0000256|HAMAP-Rule:MF_00571};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695, ECO:0000256|HAMAP-
KW Rule:MF_00571};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW Rule:MF_00571}.
FT DOMAIN 41..240
FT /note="Galactose-1-phosphate uridyl transferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01087"
FT DOMAIN 256..429
FT /note="Galactose-1-phosphate uridyl transferase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02744"
SQ SEQUENCE 520 AA; 59747 MW; FB97583C2D9676E7 CRC64;
MKVYIEVEKL ISYAVLHNLV KEDDRILVTN AVLESIGCDS YTEFTKEEQA QIAKEVAQIT
YPTEVLDRLV QWAAENGTLT TDTLTFRDLL NSKIMGQVLP RTSVIRNDFW HTYQRSKEQA
TQQFYELNKQ SNYIRTDRIA KNILWEHESP YGNLEITINL SKPEKDPRDI AAQKDVVATN
YPKCLLCKEN EGYMGRVNHA GRQNLRTIKL DLANEEWFFQ YSPYIYYNEH CIVFSSEHRP
MKIDKACFEH VLGFVEQFPH YFLSSNADLP IVGGSILSHD HFQGGRHVFP MEKATIKERV
SFKGFEDVEA GIVNWPMSVL RLRGEKDRLI ALADVILQSW INYSDESLGI YSHTEGVRHN
TVNPVARFKN GKYELDLALR NNRTDTEHPM GIFHPYEHLH NIKKENIGII EVMGLAILPG
RLKTEMASIK TLLSEAITAG NAFNTVYSQM NADSALQKHT QWLERYVNTS PTPLSIENLD
NFINRSIGDT FCEVLENCGV FKHTPKGEEG FRRFVAQAQV
//
