ID L1PDH8_9FLAO Unreviewed; 758 AA.
AC L1PDH8;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=HMPREF9073_02372 {ECO:0000313|EMBL:EKY13754.1};
OS Capnocytophaga sp. oral taxon 326 str. F0382.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Capnocytophaga.
OX NCBI_TaxID=1035193 {ECO:0000313|EMBL:EKY13754.1, ECO:0000313|Proteomes:UP000010441};
RN [1] {ECO:0000313|EMBL:EKY13754.1, ECO:0000313|Proteomes:UP000010441}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0382 {ECO:0000313|EMBL:EKY13754.1,
RC ECO:0000313|Proteomes:UP000010441};
RA Weinstock G., Sodergren E., Lobos E.A., Fulton L., Fulton R., Courtney L.,
RA Fronick C., O'Laughlin M., Godfrey J., Wilson R.M., Miner T., Farmer C.,
RA Delehaunty K., Cordes M., Minx P., Tomlinson C., Chen J., Wollam A.,
RA Pepin K.H., Bhonagiri V., Zhang X., Suruliraj S., Warren W., Mitreva M.,
RA Mardis E.R., Wilson R.K.;
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKY13754.1}.
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DR EMBL; AMEU01000166; EKY13754.1; -; Genomic_DNA.
DR RefSeq; WP_009413498.1; NZ_KB291432.1.
DR AlphaFoldDB; L1PDH8; -.
DR STRING; 1035193.HMPREF9073_02372; -.
DR PATRIC; fig|1035193.3.peg.2200; -.
DR eggNOG; COG0286; Bacteria.
DR HOGENOM; CLU_008343_0_2_10; -.
DR OrthoDB; 9814572at2; -.
DR Proteomes; UP000010441; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029464; HSDR_N.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR42998; TYPE I RESTRICTION ENZYME HINDVIIP M PROTEIN-RELATED; 1.
DR PANTHER; PTHR42998:SF1; TYPE I RESTRICTION ENZYME HINDVIIP M PROTEIN-RELATED; 1.
DR Pfam; PF13588; HSDR_N_2; 1.
DR Pfam; PF02384; N6_Mtase; 3.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Methyltransferase {ECO:0000313|EMBL:EKY13754.1};
KW Transferase {ECO:0000313|EMBL:EKY13754.1}.
FT DOMAIN 23..143
FT /note="Type I restriction enzyme R protein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13588"
FT DOMAIN 286..372
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT DOMAIN 414..487
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT DOMAIN 529..678
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT COILED 646..673
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 758 AA; 87489 MW; 7D5C1DBCBD797C87 CRC64;
MEVQIKDNKI FAPLKDKWLV LKPEEKVRQE YICRLVNSYG FDLKQMEQEV GVTNSQRGQG
RARADINVYK SEADKIASKS PVIVVECKAE HITIREEDYF QGYNYASWAG ADFFVTTNLK
ETRIFKVIKG HIPKKLEEVV NIPTAEEMKS EKKINELLKQ TKAFTRDEFS KLLFKCHNII
RNNDKLSPEA AFDEISKILF IKIRYERTNS ENQIFSLEAF RADKESYDKY KSKGDKEFYQ
LLFEKTKEDF RDDDLFEPTE IIRIRENSFE AIVKELEIYN LSTTSDDVKG IAFEEFLGKT
FRGELGQFFT PRTIVNFMVE VLDPQETETI CDPCCGSGGF LIKAFEYVRA KIEAKVQQEK
ELIKQEYYTE TYEKLSDAEK EKIDDKVNKF FSQLNEELNI NNDKSRIRTL SYDCIFGTDA
NPRMSRTAKM NMIMHGDGHG GVHHNDGLLN VNGIFENRFD VILTNPPFGA RVEKSLKITE
ADKYTDEERI KKYQKRYGDE YNKALKQVNN NIGKPLVSLY KMGAMSTLTE VLFIERCLNL
LKPGGRMGIV LPEGVLNNSN LQKVRDYVES KAKILLIVSI PQDVFIASGA TVKPSLLFFK
KFTEEEALQY ASIKSKATIT IEAKYAEEVA NIQQKLAKKG KEALPAEEKK QLKAELKNIE
AKKEREIKAI VKEEFNYTIP IAEVEKAGIS TTGARIDNEL DPLAKEFKKY TSENHLWEKL
TESVQYDVKG EFVYRIQIAD KEVGEPEIFY QKSKYENL
//