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Database: UniProt
Entry: L2GWC2_VAVCU
LinkDB: L2GWC2_VAVCU
Original site: L2GWC2_VAVCU 
ID   L2GWC2_VAVCU            Unreviewed;       899 AA.
AC   L2GWC2;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   25-OCT-2017, entry version 23.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=VCUG_00639 {ECO:0000313|EMBL:ELA47919.1};
OS   Vavraia culicis (isolate floridensis) (Microsporidian parasite).
OC   Eukaryota; Fungi; Microsporidia; Pleistophoridae; Vavraia.
OX   NCBI_TaxID=948595 {ECO:0000313|EMBL:ELA47919.1, ECO:0000313|Proteomes:UP000011081};
RN   [1] {ECO:0000313|Proteomes:UP000011081}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=floridensis {ECO:0000313|Proteomes:UP000011081};
RG   The Broad Institute Genome Sequencing Platform;
RA   Cuomo C., Becnel J., Sanscrainte N., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA   Berlin A., Chapman S.B., Gearin G., Goldberg J., Griggs A., Gujja S.,
RA   Hansen M., Heiman D., Howarth C., Larimer J., Lui A.,
RA   MacDonald P.J.P., McCowen C., Montmayeur A., Murphy C., Neiman D.,
RA   Pearson M., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA   Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The genome sequence of Vavraia culicis strain floridensis.";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; GL877410; ELA47919.1; -; Genomic_DNA.
DR   RefSeq; XP_008073660.1; XM_008075469.1.
DR   EnsemblFungi; ELA47919; ELA47919; VCUG_00639.
DR   GeneID; 19878524; -.
DR   EuPathDB; MicrosporidiaDB:VCUG_00639; -.
DR   InParanoid; L2GWC2; -.
DR   OrthoDB; EOG092C0YCY; -.
DR   Proteomes; UP000011081; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 3.
DR   Pfam; PF01496; V_ATPase_I; 3.
DR   PIRSF; PIRSF001293; ATP6V0A1; 4.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000011081};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011081};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    566    589       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    609    636       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    667    688       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    700    723       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    752    779       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    838    859       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       89    116       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   899 AA;  103199 MW;  7FF6453213C9892A CRC64;
     MRRISLYINK ENVKRALYEL GKLKLIQFVD LNAHLKNEQL PYNKEILHYE KLRSKINFLM
     GEIEAYDMEV HRNEHVFDED AIERHFNRLL ELKSIRDGAQ EQLTNLSENL FILEEMKEHD
     FSSSSCLTGI IDNDKVLLLR RILESVLKNN LVIHMKTGRR TVFVIFTHGE EAFEKIKKIC
     VSFNARIFMM KSEEEQSEKQ PKNEDNEKKD EEQKEENKDN NKGEEHEDEN QTNILRVTAL
     IQQYQHVHAN NENSIKNELG TIAQHIHTWK YKTRQVLRIL KTLNRLREST AFIGEGYVPE
     SKFPVFQNAV NTICDAHGRI AYEEQVRTGG NLEVSVLVTG NNKKRRQKRM NEREIRRLMK
     GEGSNGENRE NKIEDERYLE VDGTGSSGRA RERSAPDIES DGERSSDAQL DGMSEEKGGV
     ACTTDRSAEQ REKARDVNQA DDAESDASNS SGEKTHKNGD KTRPSGGNVQ HRTDQYEQTR
     NKRRSTKIDS DLPHKTENSS LSNSMEDIHA ARAQNEDHKV QENEMPPTFF RTNIFTRPFQ
     EMNDVYGVPS YREINPAPFT IITFPFLFGA MFGDVGHGLI LVLIAVLFIR RPELARVHEM
     VEMVVNGRYM LLACGVMSMY FGLLYSEFFG VVMPLFKFGG VTYFGVDPSW HEAKNGMNLM
     NSLKMKMSVV IGTVHMGLGL CLAAFNTVLT RDKLLFYCKV LPRILSFACF AGYLSVLIVV
     KWIRPFKPSI INTIVLMFTD PFKAEFFYPG QLYVQLFMLA LFAVCMPWMM VSYPIMLFIK
     HKRKNLSDVI IHFGIEAIEF NIGLISNISS YLRIWAVSLA HSQLTGIIHK YTMGSANVIV
     RIVSAPVWLL ATMVLMVALE GLSSSLHAMR LNWIEFNSKF YDGQGNPFQP LNFDEDSDV
//
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