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Database: UniProt
Entry: L5JQN3_PTEAL
LinkDB: L5JQN3_PTEAL
Original site: L5JQN3_PTEAL 
ID   L5JQN3_PTEAL            Unreviewed;      1754 AA.
AC   L5JQN3;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   25-OCT-2017, entry version 22.
DE   RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   ORFNames=PAL_GLEAN10019732 {ECO:0000313|EMBL:ELK01670.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Megachiroptera;
OC   Pteropodidae; Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK01670.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y.,
RA   Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y.,
RA   Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G.,
RA   Wang L.F., Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the
RT   evolution of flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. This channel gives
CC       rise to T-type calcium currents. T-type calcium channels belong to
CC       the "low-voltage activated (LVA)" group and are strongly blocked
CC       by nickel and mibefradil. A particularity of this type of channels
CC       is an opening at quite negative potentials, and a voltage-
CC       dependent inactivation. T-type channels serve pacemaking functions
CC       in both central neurons and cardiac nodal cells and support
CC       calcium signaling in secretory cells and vascular smooth muscle.
CC       They may also be involved in the modulation of firing patterns of
CC       neurons which is important for information processing as well as
CC       in cell growth processes. {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; KB031150; ELK01670.1; -; Genomic_DNA.
DR   InParanoid; L5JQN3; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0008332; F:low voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0070509; P:calcium ion import; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005445; VDCC_T_a1.
DR   InterPro; IPR030154; VDCC_T_a1G.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF137; PTHR10037:SF137; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01629; TVDCCALPHA1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000010552};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    131    150       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    222    245       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    350    371       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    377    402       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    752    770       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    782    803       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    873    892       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    949    972       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1285   1303       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1323   1344       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1356   1375       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1420   1442       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1522   1545       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1663   1682       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       94    413       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      751    977       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1283   1555       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1626   1732       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED     1554   1588       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1754 AA;  196022 MW;  5BC2FB7ECCC7F053 CRC64;
     MDEEEDGAGA EESGQPRSFM RLNDLSGAGG RPGPGSAEKD PGSADSEAEG LPYPALAPVV
     FFYLSQDSRP RSWCLRTVCN PYPPGHDGQA GRRISMLVIL LNCVTLGMFR PCEDIACDSQ
     RCRILQAFDD FIFAFFAVEM VVKMVALGIF GKKCYLGDTW NRLDFFIVIA GMLEYSLDLQ
     NVSFSAVRTV RVLRPLRAIN RVPSMRILVT LLLDTLPMLG NVLLLCFFVF FIFGIVGVQL
     WAGLLRNRCF LPENFSLPLS VDLERYYQTE NEDENPFICS QPRENGMRSC RSVPTLRGEG
     GGGPPCGLDY EAYNSSSNTT CVNWNQYYTN CSAGEHNPFK GAINFDNIGY AWIAIFQVIT
     LEGWVDIMYF VMDAHSFYNF IYFILLIIVG SFFMINLCLV VIATQFSETK QRESQLMREQ
     RVRFLSNAST LASFSEPGSC YEELLKYLVY ILRKAARRLA QVSRAAGIRA GLLSSPAPHG
     GQEPQPSSSC SRSHRRPSVH HLVHHHHHHH HHYHLGNGTL RGPRASPEIQ DRDANGSRRL
     MLPPPSTPAL SGGPPGGAEA VHSFYHADCH LEPVRCQAPA PRSPSEASGR TVSSGKVYPT
     VHTSPPPEML KEKALMEVAP TSGPPTLTSL NIPPERYSSM HKLLETQSTG TCQSSCKISS
     PCLKADSGAC GPDSCPYCAR AGAGEVELAG HEMPDSDSEA VYEFTQDAQH GDLRDPHSRR
     QRRLGLDVEP NSVLAFWRLI CDTFRKIVDS KYFGRGIMIA ILVNTLSMGI EYHEQPEELT
     NALEISNIVF TSLFALEMLL KLLVYGPFGY IKNPYNIFDG VIVVISVWEI VGQQGGGLSV
     LRTFRLMRVL KLVRFLPALQ RQLVVLMKTM DNVATFCMLL MLFIFIFSIL GMHLFGCKFA
     SERDGDTLPD RKNFDSLLWA IVTVFQILTQ EDWNKVLYNG MASTSSWAAL YFIALMTFGN
     YVLFNLLVAI LVEGFQAEEI SKREDASGQL SCIQLPVDSQ GGDATKSESE PDFFSPSLDG
     DGDRKKRFAL VSLGEHPELR RSLLPPLIIH TAATPMSLPK SSSTGLAEAL GPASRRTSSS
     GSAEPGAAHE MKSPPSARSS PHSPWSAASS WTSRRSSRNS LGRASSLKRR SPSGERRSLL
     SGEGQESQDE EESSEEERAS PAGSDRRHGG SLEREAKSSF DLPDTLQVPG LHRTASGRSS
     TSEHQDCNGK SALGHLARSL RPDDPPLDGD DGDDEGNLSK GERMRAWIRA RLPACCRERD
     SWSAYIFPPQ SRFRLLCHRI ITHKMFDHVV LVIIFLNCIT IAMERPKIDP HSAERIFLTL
     SNYVFTAVFL AEMTVKVVAL GWCFGEQAYL RSSWNVLDGL LVLISIIDIL VSMVSDSGTK
     ILGMLRVLRL LRTLRPLRVI SRAQGLKLVV ETLMSSLKPI GNIVVICCAF FIIFGILGVQ
     LFKGKFFVCQ GEDTRNITNK SDCAEARYRW VRHKYNFDNL GQALMSLFVL ASKDGWVDIM
     YDGLDAVGVD QQPIMNHNPW MLLYFISFLL IVAFFVLNMF VGVVVENFHK CRQHQEEEEA
     RRREEKRLRR LEKKRRSKEK QMADLMLDDV IASGSSASAA PEAQCKPYYS DYSRFRLLVH
     HLCTSHYLDL FITGVIGLNV VTMAMEHYQQ PQILDEALKI CNYIFTVIFV LESVFKLVAF
     GFRRFFQDRW NQLDLAIVLL SIMGITLEEI EVNASLPINP TIIRIMRVLR IARGQCPATC
     PPHPPFQGDW PWET
//
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