ID L5JR19_PTEAL Unreviewed; 1493 AA.
AC L5JR19;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Roundabout like protein 1 {ECO:0000313|EMBL:ELK00573.1};
GN ORFNames=PAL_GLEAN10016377 {ECO:0000313|EMBL:ELK00573.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK00573.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
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DR EMBL; KB031157; ELK00573.1; -; Genomic_DNA.
DR STRING; 9402.L5JR19; -.
DR eggNOG; KOG4222; Eukaryota.
DR InParanoid; L5JR19; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0008046; F:axon guidance receptor activity; IEA:InterPro.
DR GO; GO:0016199; P:axon midline choice point recognition; IEA:InterPro.
DR GO; GO:0035385; P:Roundabout signaling pathway; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR CDD; cd05725; IgI_3_Robo; 1.
DR CDD; cd05726; IgI_4_Robo; 1.
DR CDD; cd20952; IgI_5_Robo; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR032986; Robo1_Ig-like3.
DR PANTHER; PTHR45080; CONTACTIN 5; 1.
DR PANTHER; PTHR45080:SF32; MYOTILIN; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 2.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 4.
DR SMART; SM00406; IGv; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..78
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 83..167
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 172..267
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 276..362
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 384..478
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 497..594
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 602..698
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 898..922
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 943..1149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1166..1211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1234..1493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 943..981
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1065..1082
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1107..1122
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1171..1211
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1249..1267
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1330..1353
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1368..1391
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1404..1435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1464..1493
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1493 AA; 163709 MW; F8C45B8B73762291 CRC64;
MVAVGEPAVM ECQPPRGHPE PTISWKKDGS PLDDKDERIT IRGGKLMITY TRKSDAGKYV
CVGTNMVGER ESEVAELTVL ERPSFVKRPS NLAVTVDDSA EFKCEARGDP VPTVRWRKDD
GELPKSRYEI RDDHTLKIRK VMAGDMGSYT CVAENMVGKA EASATLTVQE PPHFVVKPRD
QVVALGRTVT FQCEATGNPQ PAIFWRREGS QNLLFSYQPP QSSSRFSVSQ TGDLTITNVQ
RSDVGYYICQ TLNVAGSIIT KAYLEVTDVI ADRPPPVIRQ GPVNQTVAVD GTLVLSCVAT
GSPVPTILWR KDGVLVSTQD SRIKQLETGV LQIRYAKLGD TGRYTCIAST PSGEATWSAY
IEVQEFGVPV QPPRPTDPNL IPSAPSKPEV TDVSRNTVTL SWQPNLNSGA TPTSYIIEAF
SHASGSSWQT VAENVKTEVF SIKGLKPNAI YLFLVRAANA YGISDPSQIS DPVKTQDVPP
TSQGVDHKQV QRELGNVVLH LHSPTILSSS SVEVHWTVDQ QSQYIQGYRI LYRPSGANHG
ESEWSVFEVR TPTQNSVVIP DLKKGVNYEI KARPFFNEFQ GADSEIKFAR TLEEGKYNED
APPQSVTVSK NDGNGTAILV TWQPPPEDTQ NGMVQEYKVW CLGNETRYHI NKTVDGSTFS
VVIPSLIPGI RYSVEVAAST GAGPGVKSEP QFIQLDSHGN PVSPEDQVSL AQQISDVVKQ
PAFIAGIGAA CWIILMVFSI WLYRHRKKRN GLTSTYAGIR KVTYQRGGEA VSSGGRPGLL
NISEPAAQPW LADTWPNTGN NHNDCSINCC TAGSGNSDSN LTTYSRPADC IANYNNQLDN
KQTNLMLPES TVYGDVDLSN KINEMKTFNS PNLKDGRFVN PSGQPTPYAT TQLIQSNLSS
SMNNGGGDSG EKHWKPPGQQ KQEVTPIQYN IMEQNKLNKD YRANDTIPST IPYNQSYDQN
TGGSYNSSDR GSSTSGSQGH KKGARTPKVP KQGGMNWADL LPPPPAHPPP HSNSEEYSIS
VDESYDQEMP CPVAPARMYL QQDELEEEDE RGPTPPVRGA ASSPAAVSYS HQSTATLTPS
PQEEPQPMLP DCPEEIGHMQ HQPDRRRQPV SPPPPPRPIS PPHTYGYISG PLVSDMDTDA
PEEEEDEADL EVAKMQTRRL LLRGLEQTPA SSVGDLESSV TGSMINGWGS ASEEDNISSG
RSSVSSSDGS FFTDADFAQA VAAAAEYAGL KVARRQMQDA AGRRHFHTSQ CPRPTSPVST
DSNMSAAVMQ KARPAKKQKH QPGHLRRETY TDDLPPPPVP PPAIKSPTVQ SKAQLEVRPV
MVPKLPCIES RTDRSSDRKG GNYKGRELLD GRQVADMRTN PSESREAQEQ QNDGKGRGNK
AAKRDLPPAK THLIQEDILP YCRPTFPTSN NPRDPSSSSS MSSRGSGSRQ REQGNVGRRN
IAEMQVLGAY ERGEDNNEEL ELEINQKEEE RTQRMKNNER EIQGLADTIR RET
//
