ID   L5JSD4_PTEAL            Unreviewed;       929 AA.
AC   L5JSD4;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   SubName: Full=Proto-oncogene DBL {ECO:0000313|EMBL:ELK02215.1};
GN   ORFNames=PAL_GLEAN10007721 {ECO:0000313|EMBL:ELK02215.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC   Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK02215.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA   Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA   Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA   Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the evolution of
RT   flight and immunity.";
RL   Science 339:456-460(2013).
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DR   EMBL; KB031147; ELK02215.1; -; Genomic_DNA.
DR   AlphaFoldDB; L5JSD4; -.
DR   STRING; 9402.L5JSD4; -.
DR   eggNOG; KOG4240; Eukaryota.
DR   InParanoid; L5JSD4; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   Gene3D; 1.20.58.60; -; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR018159; Spectrin/alpha-actinin.
DR   PANTHER; PTHR22826:SF146; PROTO-ONCOGENE DBL; 1.
DR   PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR   Pfam; PF13716; CRAL_TRIO_2; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00516; SEC14; 1.
DR   SMART; SM00150; SPEC; 1.
DR   SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF46966; Spectrin repeat; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552}.
FT   DOMAIN          157..250
FT                   /note="CRAL-TRIO"
FT                   /evidence="ECO:0000259|PROSITE:PS50191"
FT   DOMAIN          656..746
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          899..929
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          405..435
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        901..929
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   929 AA;  107376 MW;  4923DDBC78F7C305 CRC64;
     MAAEDSRPYL GSPTLVPRHV LQAPAQRISV LGGRTLGLPL NQDRCTFVST AQAIPLQVDM
     GMALQRLRIA ERYGKNYLCL LQAVFVAESK LHLRVKDISH FLMQDIAFLS GGRGKDNAWI
     ITFPENCNFR CIPEDVIVKV LTYLTSVARQ NGSDSRFTII LDRRLDTWSS LKISLQKISA
     SFPGNLHLVL VLRPTSFLQR TFTDIGFRFS HEDFMVKLPV VMLSSVSDLL AYIDDKQLTP
     ELGGTLQYCH SEWIIFRNAI ENFALTVKEM AQMLQSFGTE LAETELPDDI PSIEEILAVR
     AERYHLLKND ITTVTKEGKV LLTNLEVPDT EEAVSSRLEH HQISGDWQTI NKLLTQVHDM
     ESAFDGFWEK HQMKMEQYLQ LWKFEQDFQE LVSEVEFLLN QQAELADVTG NISQIKQKIK
     KLENLDENSQ DLLAKARFVI LHGHRLAANH HYALDLICQR CNELRYLSDI LVNEIKTKRI
     QLSRTFKMHK LLQQALQCCD EGECLLANQE IDKFQSKEDA QKALRDIEHF LEMALPFINY
     DPETLQYEFD IILSPELKIQ MQTVQFKLEN IRNIFENQQA GFRKLQDNHM RPMQFMVPSS
     NNMIRSQTPF FSPNPVKKTW RQNQSSVKIE AVHECRETRS SAQSSSLNND NNLDILKNHV
     LNELIQTEKV YVRELFTVLL GYKAEMDNPD MFDLMPPLLR NKKDILFGNM AEIYEFHNKY
     ELLKYSKGCE GFEKLKEALD TVLDLLKSVN DSMHQAAING YIMDEVGITE YVKGDNRKFE
     IWYAGKEVYI IQAPTVDVKM TWLKEIRSIL LKQQELMTIK EQERYNQLAQ QDQNSSQRND
     EIHQGAFIVP EETESVHTSN VVEVGEAIAS AQAGATAVWT ERTVEWSNNY FYSSCVNNEE
     EERPPMVDEK SKQKKRRPHS REQFADFNR
//