ID   L5JT76_PTEAL            Unreviewed;       777 AA.
AC   L5JT76;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN   ORFNames=PAL_GLEAN10022413 {ECO:0000313|EMBL:ELK02520.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC   Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK02520.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA   Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA   Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA   Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the evolution of
RT   flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- SIMILARITY: Belongs to the OSBP family.
CC       {ECO:0000256|RuleBase:RU003844}.
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DR   EMBL; KB031122; ELK02520.1; -; Genomic_DNA.
DR   AlphaFoldDB; L5JT76; -.
DR   STRING; 9402.L5JT76; -.
DR   eggNOG; KOG2210; Eukaryota.
DR   InParanoid; L5JT76; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   CDD; cd13286; PH_OPR5_ORP8; 1.
DR   Gene3D; 1.10.287.2720; -; 1.
DR   Gene3D; 2.40.160.120; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR037239; OSBP_sf.
DR   InterPro; IPR000648; Oxysterol-bd.
DR   InterPro; IPR018494; Oxysterol-bd_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR10972:SF218; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 8; 1.
DR   Pfam; PF01237; Oxysterol_BP; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS01013; OSBP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW   ECO:0000256|RuleBase:RU003845};
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT   DOMAIN          106..223
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          1..87
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          280..357
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          708..745
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        44..68
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        69..87
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        280..328
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   777 AA;  88590 MW;  E6A88B6275F668D8 CRC64;
     MSQRQGKEAY PTPTRDLYQP SFSPASPHSQ GFERGKEDIS QTKDESSLSM SKSKSESKLY
     NGSEKDSSAS SKLTKKESLK VQKKNYREEK KRATKELLST ITDPSVIVMA DWLKIRGTLK
     SWTKLWCVLK PGVLLIYKTQ KNGQWVGTVL LNACEIIERP SKKDGFCFKL FHPLEQSIWA
     VKGPKGEAVG SITQPLPSSY LIIRATSESD GRCWMDALEL ALKCSSLLKR TMIREGKEHD
     LSISSESTHV TLYGLLRANN LHSGDNFQLN DSEIERQHFK DQDMYSDKSD KENDQEHDES
     DNEVMGKSEE SDTDTSERQD DSYIEPEPVE PLKETTYTEQ SHEELGEAGE ASQTETVSEE
     NKSLIWTLLK QVRPGMDLSR VVLPTFILEP RSFLDKLSDY YYHADFLSEA ALEENPYFRL
     KKVVKWYLSG FYKKPKGLKK PYNPILGESF RCLWIHPRTN SKTFYIAEQV SHHPPISAFY
     VSNRKDGFCL SGSILAKSKF YGNSLSAILE GEARLTFLNR GEDYVMTMPY AHCKGILYGT
     MTLELGGTVN ITCQKTGYSA ILEFKLKDSE VFINDKKTDN SEVFWNPTPD IKQWRLIRHT
     VKFEEQGDFE SEKLWQRVTR AINVKDQTEA TQEKYVLEEA QRQAARDRKT KNEEWACKLF
     ELDPLTGEWH YKFADTRPWD PLNDMIQFEK DGVIQTKVKH RTPMVSVPKM KHKPTRQQKK
     VAKGYSSPEP DIQDSSGSEV IPGPGNVAKY AAESIKPAAG DLDQAPPYLS CIPKLVS
//