ID L5JVS7_PTEAL Unreviewed; 1686 AA.
AC L5JVS7;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
DE Flags: Fragment;
GN ORFNames=PAL_GLEAN10001453 {ECO:0000313|EMBL:ELK03415.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK03415.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry
CC of calcium ions into excitable cells and are also involved in a variety
CC of calcium-dependent processes, including muscle contraction, hormone
CC or neurotransmitter release, gene expression, cell motility, cell
CC division and cell death. {ECO:0000256|RuleBase:RU003808}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR EMBL; KB031088; ELK03415.1; -; Genomic_DNA.
DR STRING; 9402.L5JVS7; -.
DR eggNOG; KOG2301; Eukaryota.
DR InParanoid; L5JVS7; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 6.10.250.2180; -; 1.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR031688; CAC1F_C.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR005446; VDCC_L_a1su.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF2; VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16885; CAC1F_C; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 5.
DR PRINTS; PR00167; CACHANNEL.
DR PRINTS; PR01630; LVDCCALPHA1.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|PIRSR:PIRSR602077-3};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 71..88
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 108..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 139..155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 212..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 275..296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 308..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 493..512
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 555..578
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 642..660
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 680..700
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 712..738
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 758..784
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 872..899
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 950..971
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 983..1002
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1148..1171
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1271..1305
FT /note="Voltage-dependent calcium channel alpha-1 subunit
FT IQ"
FT /evidence="ECO:0000259|SMART:SM01062"
FT REGION 1332..1457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1527..1548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1335..1358
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1405..1425
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 289
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 545
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 845
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT CARBOHYD 254
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-3"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ELK03415.1"
SQ SEQUENCE 1686 AA; 189938 MW; AB17E941DB1AC114 CRC64;
KRRTQHSKHK TVAAASAQRS PRALFCLTLA NPLRRSCISI VEWKHPGRPR ADLRGCSAWV
LDYVYLRPFD ILILLTIFAN CVALGVYIPF PEDDSNTANH NLEQVEYVFL VIFTVETVLK
IVAYGLVLHP SAYIRNGWNL LDFIIVVVGL FSVLLEQGPG RPGDAPHTGG KPGGFDVKAL
RAFRVLRPLR LVSGVPSLHI VLNSIMKALV PLLHIALLVL FVIIIYAIIG LELFLGRMHK
TCYFLGSGRV CTLNQTECRG RWAGPNGGIT NFDNFFFAML TVFQCVTMEG WTDVLYWMQD
AMGYELPWVY FVSLVIFGSF FVLNLVLGVL SGEFSKEREK AKARGDFQKL REKQQLEEDL
RGYLDWIMQA EELDIEDPSA DDNFCSVAEE GRAGHQYANK VLLCLFTVEM LLKLYGLGPS
AYVSSFFNRF DCFVVCGGIL ETTLVEVGAM QPLGISVLRC VRLLRIFKVT RHWASLSNLV
ASLLNSMKSI ASLLLLLFLF IIIFSLLGMQ LFGGKFNFDQ THTKRSTFDT FPQALLTVFQ
ILTGEDWNVV MYDGIMAYGG PFFPGMLVCI YFIILFICGN CMEEEEEEEE EEEEGGAGRV
ELLQEVVPKE KVVPIPEGSA FFCLSQTNSL RKACHTLIHH HVFTNLILVF IILSSVSLAA
EDPIRAHSFR NHILGYFDYA FTSIFTVEIL LKMTVFGAFL HQGSFCRSWF NLLDLLVVSV
SLISFGIHSS AISVVKILRV LRVLRPLRAI NRAKGLKHVV QCVFVAIRTI GNIMIVTTLL
QFMFACIGVQ LFKPVCNIHR GSFLVYPDGD VSRPLVRERL WVNSDFNFDN VLSAMMALFT
VSTFEGWPAL LYKAIDAHAE DEGPIYNYHV EISVFFIVYI IIIAFFMMNI FVGFVIITFR
AQGEQEYQNC ELDKNQRQCV EYALKAQPLR RYIPKNPHQY RVWATVNSAA FEYLMFLLIL
LNTVALAMQH YEQTAPFNYA MDILNMVFTG LFTIEMVLKI IAFKPKHYFA DAWNTFDALI
VVGSVVDIAV TEVNSSEDSS RISITFFRLF RVMRLVKLLS KGEGIRTLLW TFIKSFQMFG
KVALQDGTQI NRNNNFQTFP QAVLLLFRCA TGEAWQEIML ATLPGNRCDP ESDFGPGEEF
TCGSNFAIAY FISFFMLCAF LIINLFVAVI MDNFDYLTRD WSILGPHHLD EFKRIWSEYD
PGAKGRIKHL DVVALLRRIQ PPLGFGKLCP HRVACKRLVA MNMPLNSDGT VTFNATLFAL
VRTSLKIKTE EEEVTVGKFY ATFLIQDYFR KFRRRKEKGL LGTEAPPSTS SALQAGLRSL
QDLGPEIRQA LTCDTDQEEE EEKEEEEERQ EGEEEEDKDP ETYKAPIGFQ PPSRRRSSVI
SLSLPAGDKL PDSLSLGPSD DDGGAPNSRQ FSVPQAGSHT HRRSSGALIF TIPEERSSQP
KGTEEEEKQD EEEEVPSQFS DLNMLSYLDE QAGTPLHPIL LPPHRPQRYV GGHRVPHRRL
LPPTPAGRKP SFTIQCLRRQ SSCEDLPIPG TYHRGRNSGL SRTQGSWATP PQRGRLLYAP
LLLVEEGTAG EGYLGKSSGP LRTFTCLHVP GTHSDPSHVK RGSADSLVEA VLISEGLGLF
ARDPHFVALA KQEIADACRL TLDEMDSAAS DLLAQGTSSF YSDEESIRSR FDEEDLRDEM
ACIHGL
//