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Database: UniProt
Entry: L5K1L9_PTEAL
LinkDB: L5K1L9_PTEAL
Original site: L5K1L9_PTEAL 
ID   L5K1L9_PTEAL            Unreviewed;      1961 AA.
AC   L5K1L9;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   07-JUN-2017, entry version 31.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   ORFNames=PAL_GLEAN10025915 {ECO:0000313|EMBL:ELK04656.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Megachiroptera;
OC   Pteropodidae; Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK04656.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y.,
RA   Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y.,
RA   Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G.,
RA   Wang L.F., Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the
RT   evolution of flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; KB031068; ELK04656.1; -; Genomic_DNA.
DR   InParanoid; L5K1L9; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000010552};
KW   Ion channel {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000313|EMBL:ELK04656.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    125    148       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    208    228       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    358    385       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    708    732       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    744    765       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    827    855       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    917    940       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1166   1184       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1205   1227       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1233   1253       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1282   1308       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1406   1430       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1488   1506       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1518   1536       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1543   1568       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1605   1633       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1709   1732       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      166    392       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      466    666       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      717    945       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      954   1160       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1164   1438       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1487   1742       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      382    427       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1961 AA;  222687 MW;  CE79F7181410321E CRC64;
     MAQSVLVPPG PDSFRFFTRE SLAAIEQRIA EEKATRPKQE RKDEDDENGP KPNSDLEAGK
     SLPFIYGDIP PEMVSEPLED LDPYYINKKT FIVLNKGKAI SRFSATSALY ILTPFNPIRK
     LAIKILYSTL FNVLIMCTIL TNCVFMTMSN PPDWTKNVEY VTEFVDLGNV SALRTFRVLR
     ALKTISVIPG LKTIVGALIQ SVKKLSDVMI LTVFCLSVFA LIGLQLFMGN LRNKCLQWPP
     DNSSFEINIT SFFNNSLDGN GTTFNRTMSM FNWDDYIEDK SHFYFLEGQN DALLCGNSSD
     AGQCPEGYIC VKAGRNPNYG YTSFDTFSWA FLSLFRLMTQ DFWENLYQLT LRAAGKTYMI
     FFVLVIFLGS FYLINLILAV VAMAYEEQNQ ATLEEAEQKE AEFQQMLEQL KKQQEEAQAA
     AAAASAESKD FSGAGGIGVF SESSSVASKL SSKSEKELKN RRKKKKQKEQ SGEEEKEDGV
     RKSESEDSIR RKGFRFSLEG SRLTYEKRFS SPHQSLLSIR GSLFSPRRNS RASLFSFRGR
     AKDIGSENDF ADDEHSTFED NDSRRDSLFV PHRHGERRHS NVSQASRASR VLPILPMNGK
     MHSAVDCNGV VSLVGGPSLT SPAGQLLPEG TTTETEIKKR RSSSYHVSMD LLEDPTTRQR
     TMSIASILTN TMEELEESRQ KCPPCWYKFA NMCLIWDCCK PWLKVKHLVN LVVMDPFVDL
     AITICIVLNT LFMAMEHYPM TEQFSSVLSV GNLVFTGIFT AEMFLKIIAM DPYYYFQEGW
     NIFDGLIVSL SLMELGLANV EGLSVLRSFR LLRVFKLAKS WPTLNMLIKI IGNSVGALGN
     LTLVLAIIVF IFAVVGMQLF GKSYKECVCK ISNDCELPRW HMHDFFHSFL IVFRVLCGEW
     IETMWDCMEV AGQTMCLTVF MMVMVIGNLV VLNLFLALLL SSFSSDNLAA TDDDNEMNNL
     QIAVGRMQKG IDYVKRKIRE FIQKAFVRKQ KVLDEIKPLE DLNNKKDSCI SNHTTIEIGK
     DLNYLKDGNG TTSGIGSSVE KYVVDESDYM SFINNPSLTV TVPIAVGESD FENLNTEEFS
     SESDMEESKE KLNATSSSEG STVDIGAPAE GEQPEVEPEE SLEPEACFTE DCVRKFKCCQ
     ISIEEGKGKL WWNLRKTCYK IVEHNWFETF IVFMILLSSG ALAFEDIYIE QRKTIKTMLE
     YADKVFTYIF ILEMLLKWVA YGFQMYFTNA WCWLDFLIVD VSLVSLTANA LGYSELGAIK
     SLRTLRALRP LRALSRFEGM RVVVNALLGA IPSIMNVLLV CLIFWLIFSI MGVNLFAGKF
     YHCINYTTGE MFDVSVVNNY SECRALIENN QTARWKNVKV NFDNVGLGYL SLLQVATFKG
     WMDIMYAAVD SRNVELQPKY EDNLYMYLYF VIFIIFGSFF TLNLFIGVII DNFNQQKKKI
     SQDIFMTEEQ KKYYNAMKKL GSKKPQKPIP RPANKFQGMV FDFVTKQVFD ISIMILICLN
     MVTMMVETDD QSQEMTNILY WINLVFIVLF TGECVLKLIS LRYYYFTIGW NIFDFVVVIL
     SIVGMFLAEL IEKYFVSPTL FRVIRLARIG RILRLIKGAK GIRTLLFALM MSLPALFNIG
     LLLFLVMFIY AIFGMSNFAY VKREVGIDDM FNFETFGNSM ICLFQITTSA GWDGLLAPIL
     NSGPPDCDPE KDHPGSSVKG DCGNPSVGIF FFVSYIIISF LVVVNMYIAV ILENFSVATE
     ESAEPLSEDD FEMFYEVWEK FDPDATQFIE FSKLSDFAAA LDPPLLIAKP NKVQLIAMDL
     PMVSGDRIHC LDILFAFTKR VLGESGEMDA LRIQMEERFM ASNPSKVSYE PITTTLKRKQ
     EEVSAIVIQR AYRRYLLKQK VKKVSSIYKK DKGKEGDGTP IKEDILIDKL NENSTPEKTD
     VTPSTTSPPS YDSVTKPEKE KFEKDKSEKE DKGKDIRESK K
//
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