GenomeNet

Database: UniProt
Entry: L5K1X7_PTEAL
LinkDB: L5K1X7_PTEAL
Original site: L5K1X7_PTEAL 
ID   L5K1X7_PTEAL            Unreviewed;      4636 AA.
AC   L5K1X7;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   10-MAY-2017, entry version 25.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|EMBL:ELK05575.1};
GN   ORFNames=PAL_GLEAN10023653 {ECO:0000313|EMBL:ELK05575.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Megachiroptera;
OC   Pteropodidae; Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK05575.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y.,
RA   Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y.,
RA   Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G.,
RA   Wang L.F., Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the
RT   evolution of flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; KB031042; ELK05575.1; -; Genomic_DNA.
DR   InParanoid; L5K1X7; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 9.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000010552};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:ELK05575.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3949   3973       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4177   4197       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4245   4264       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4376   4394       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4437   4458       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4517   4540       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      119    174       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      181    226       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      234    288       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      294    352       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      362    419       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      604    815       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1031   1227       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1273   1485       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3685   3720       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4636 AA;  525185 MW;  87AC4E8F99F2C264 CRC64;
     MPPTVTDNDV ARVTWGLVLH GETVPGHPHL CLFSWQEDEV VLQCIANIHK EQRKFCLAAE
     GLGNRLCFLE PTSEAKYVPP DLCVCNFVLE QSLSVRALQE MLANTGENGS EGAAQGGGHR
     TLLYGHAILL RHSFSRMYLT CLTTSRSQTD KLAFDVGLRE HATGEACWWT IHPASKQRSE
     GEKVRIGDDL ILVSVSSERY LHLSISNATI QVDASFMQTL WNVHPTCSGS SIEEGYLLGG
     HVVRLFHGHD ECLTILSTDQ NDSQHRRIFY EAGGAGTRAR SLWRVEPLRI SWSGSNIRWG
     QAFRLRHLTT GHYLALTEDQ GLILQDRGKS DTKSTAFSFR ASKEIKEKLD SSHKRDIEGM
     GVPEIKYGDS VCFVQHVASG LWVTYKAQDA KTPRLGPLKR KVILHQEGHM DDGLTLQRCQ
     HEESQAARII RNTTALFSQF ISGNSRTAAP ITLPIEEVLQ TLQDLIAYFQ PPEEEMQHED
     KQNKLRSLKN RQNLFKEEGM LALVLNCIDR LNIYNSVAHF AGIAREESGM AWKEILNLLY
     KLLAALIRGN RNNCAQFSNN LDWLISKLDR LESSSGILEV LHCILIESPE ALNLIAEGHI
     RSIISLLDKH GRNHKVLDVL CSLCLCNGVA VRANQNLICD NLLPRRNLLL QTRLINNVTS
     IRPNILLGVA EGSAQYKKWY FELIIDQVDP FLTAEPTHLR VGWASSSGYA PYPGGGEGWG
     GNGVGDDLYS YGFDGLHLWS GRIPRAVASI NQHLLKSDDV VSCCLDLGVP SISFRINGQP
     VQGMFENFNT DGLFFPVVSF SAGVKVRFLM GGRHGEFKFL PPSGYAPCYE ALLPKEKMRL
     EPVKEYKRDT EGIRDLLGTT QFLSQASFIP CPIDTSQVVL PPHLEKIRDR LAENIHELWG
     MNKIELGWTF GKIRDDNKRQ HPCLVEFSKL PETEKNYNLQ MSTETLKTLL ALGCHIAHVN
     PAAEEDLKKV KLSKNYMMSN GYKPAPLDLS DVKLLPPQEI LVDKLAENAH NVWAKDRIKQ
     GWTYGIQQDL KNKRNPRLVP YALLDERTKK SNRDSLREAV RTFVGYGYNI EPSDQELADP
     AVEKVSIDKI RFFRVERSYA VRSGKWYFEF EVVTGGDMRV GWARPGCRPD VALGADDQAF
     VFEGSRGQRW HQGSGYFGRT WQPGDVVGCM INLDDASMIF TLNGELLITN KGSELAFADY
     EIENGFVPIC SLGLSQIGRM NLGMDASTFK FYTMCGLQEG FEPFAVNMNR DVAMWFSKRL
     PTFVNVPKDH PHIEVVRIDG TMDSPPCLKV THKTFGTQNS NASMIYCRLS MPVECHSSFS
     HSPCLDSEAF QKRKQMQEIL SQTTTQCYYA IRIFAGQDPS CVWVGWVTPD YHLYSEKFDL
     NKNCMVTVTL GDERGRVHES VKRSNCYMVW GGDIVATSQR SSRSNVDLEI GCLLDLAMGM
     LSFSANGREL GTCYQVEPNT KVFPAVFLQP TSTSLFQFEL GKLKTAMPLS AAIFKSEEKN
     PVPQCPPRLD VQTIQPVLWS RMPSSFLKVE TERVSERHGW VVQCLEPLQM MALHIPEENR
     CVDILELCEQ EDLMQFHYHT LRLYSAVCAL GNSRVAYALC SHVDLSQLFY AIDNKYLPGL
     LRSGFYDLLI SIHLANAKER KLMMKNEYII PINSTTRKIR LYPDEFKRHG LPGVGLRTCL
     KPGFRFSTPC VVMTSEEHQK QSPEIPLEIL KTKALSMLTE AVQCSGAHIR DPVGGSVEFQ
     FVPVLKLIGT LLVMGVFDDD DVRQILLLID PSVFGEHSGE TEEGAEKEEV TQVEEKAVEA
     GEKASKEAPV KGLLQTRLPE SVKLQMCELL SYLCDCELQH RVEAIVAFGD IYVSKLQANQ
     KFRYNELMQA LNMSAALTAR KTKEFRSPPQ EQINMLLNFQ LGENCPCPDE IREELYDFHE
     DLLTHCGVPL EGEEEEEEDS SWTGKLRAFL YKIRGPPKPE KEQPKEEEER CPTTLKELIS
     QTMIRWAQED QIQDAELVRM MFTLLRRQYD SVGELLRALR KTYSISQASV SDTIGLLAAL
     GQIRCLLSVR MGKEEELLMI NGLGDIMNNK VFYQHPNLMR VLGMHETVME VMVNVLGAEK
     SQIAFPKMVA SCCRFLCYFC RISRQNQKAM FEHLSYLLEN SSVGLASPSM RGSTPLDVAA
     SSVMDNNELA LGLEEPDLEK VVTYLAGCGL QSCAMLLARG YPDVGWNPIE GERYLSFLRF
     AVFVNSESVE ENASVVVKLL IRRPECFGPA LRGEGGNGLL AAMQGAIKIS ENPALDLPSQ
     GCKREVSTED NEDEEIVHMG NAIMSFYSAL IDLLGRCAPE MHLIRTGKGE AIRIRSILRS
     LVPTEDLVGI ISIPLKLPSL NKDGSVSEPD MAANFCPDHK APMVLFLDRV YGIKDQAFLL
     HLLEVGFLPD LRASASLDTV SLSTTEAVLA LNRYVCSAVL PLLTRCAPLF AGTEHYTSLI
     DSTLQTIYRL SKGRSLTKAQ RDTIEECLLA ICNHLRPSML QQLLRRLVFD VPQLNEYCKM
     PLKKYDPDLF RMALPCLSAI AGALPPDYLD TRISATLEKQ ISVDTDGNFD PKPINTMNFP
     VPEKLEYIVT KYAEHSHDKW ACDKEKEIYR WPARESLKTM LAVGWTVERT KEGDALAQQR
     ENEKLRNVSQ ASQGNSYSPA PLDLSNVVLS KELQGMVEVV AENYHNIWAK KKKLELESKG
     GGSHPLLVPY DTLTAKEKFK DREKAQDLFK FLQVNGIVVS RGMKDMELDA SSMEKRFAYK
     FLKKILKYVD SAQEFIAHLE AIVSSGKTEK SPHDQEIKFF AKVLLPLVDQ YFTNHRLYFL
     SSPLKPLSSS GYASHKEKEM VARTVMKSGS ELVKAGLRAF FENAAEDLEK TSENLKLGKF
     THSRTQIKGV SQNINYTTVA LLPILTSIFE HVAQHQFGAD LLLGDVQISC YHILCSLYSL
     GTGKNIYVER QRPALGECLA SLAAAIPVAF LEPTLNRYNP LSVFNTKTPR ERSILGMPDT
     VEEMCPDIPQ LEGLMKEIND LAESGARYTE MPHVIEVILP MLCNYLSYWW ERGPEHLPPS
     TGPWCTKVTS EHLSVILGNI LKIINNNLGI DEASWMKRIA VYAQPIISKA RPDLLRSHFI
     PTLEKLKKKA VKTVQEEEQL KADSKGDTQE AELLILDEFA VLCRDLYAFY PMLIRYVDNS
     RSNWLKSPDA DSDQLFRMVA EVFILWCKSH NFKREEQNFV IQNEINNLAF LTGDSKSKMS
     KSGGQDQERK KTKRRGDLYS IQTSLIVAAL KKMLPIGLNM CTPGDQELIS LAKSRYSYRD
     TDEEVKEHLR NNLHLQEKSD DPAVKWQLNL YKDVLKSEEP SNPERTVERV QRISAAVFHL
     EQKSPKVEEE EEEETEKQPD PLHQIILHFS RNALTERSKL EDDPLYTSYS SMMAKSCQSG
     EDEEEEEDKE KTFEEKEMEK QKTLYQQARL HERGAAEMVL QMISASKVIV RERGEKVLQN
     DEFTRDLFRF LQLLCEGHNS GMTGTGSDPA LVLSDFQNFL RTQMGNTTTV NVIISTVDYL
     LRLQESISDF YWYYSGKDII DESGQHNFSK ALAVTKQIFN SLTEYIQGPC IGNQQSLAHS
     RLWDAVVGFL HVFANMQMKL SQDSSQIELL KELLDLLQDM VVMLLSLLEG NVVNGTIGKQ
     MVDTLVESST NVEMILKFFD MFLKLKDLTS SDTFKEYDPD GKGILSKKEF QKAMEGQKQY
     TQSEIEFLLS CAEADENDMF NYIDFVDRFH EPAKDIGFNV AVLLTNLSEH MPNDSRLKCL
     LDPAESVLNY FEPYLGRIEI MGGAKKIERV YFEISESSRT QWEKPQVKES KRQFIFDVVN
     EGGEQEKMEL FVNFCEDTIF EMQLASQISE SDSADRPEEE EEDEDSSYTS EIEGEEEDKK
     SFESASAFAM ACASVKRNVA NFLKRATLKN LRKQYRKVKK MTVKELVRVF FSFFWMMFVG
     LFQLFFTILG GIFQILWNTV FGGGLVEGAK NIRVTKILGD MPDPTQFGIH DDAVEAERAE
     VTEPGITTEL VHFIKGEKGN ADIMSDLFGF HSKKEGGIKH GPEVGLGDLS EIIGKDEPPT
     LESTVRKKRK AQAAEMKAAD ESEGKVEPEK ADMEDGEKED TAREGEQAKA LWAEVTKKKK
     RRRGQKVEKP EALMANFFKG LEIYQTKLLH YLARNFYNLR FLALFVAFAI NFILLFYKVT
     EEPLEEEAED IANLWHSFND EEEEEAMVFF VLQESTGYMA PTLRALAVIH TVISLVCVVG
     YYCLKVPLVV FKREKEIARK LEFDGLYITE QPSEDDIKGQ WDRLVINTPS FPNNYWDKFV
     KRKVINKYGD LYGAERIAEL LGLDKNALDF SPVEETKAEA ASLVSWLSSI DMKYHIWKLG
     VVFTDNSFLY LAWYTTMSIL GHYNNFFFAA HLLDIAMGFK TLRTILSSVT HNGKQLVLTV
     GLLAVVVYLY TVVAFNFFRK FYNKSEDDDE PDMKCDDMMT CYLFHMYVGV RAGGGIGDEI
     EDPAGDPYEM YRIVFDITFF FFVIVILLAI IQGLIIDAFG ELRDQQEQVR EDMETKCFIC
     GIGNDYFDTT PHGFETHTLQ EHNLANYLFF LMYLINKDET EHTGQESYVW KMYQERCWDF
     FPAGDCFRKQ YEDQLG
//
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