ID L5K4R6_PTEAL Unreviewed; 717 AA.
AC L5K4R6;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Protein Hook like protein 2 {ECO:0000313|EMBL:ELK06714.1};
GN ORFNames=PAL_GLEAN10002774 {ECO:0000313|EMBL:ELK06714.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK06714.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the hook family.
CC {ECO:0000256|ARBA:ARBA00006946}.
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DR EMBL; KB030998; ELK06714.1; -; Genomic_DNA.
DR RefSeq; XP_006918794.1; XM_006918732.2.
DR AlphaFoldDB; L5K4R6; -.
DR STRING; 9402.L5K4R6; -.
DR GeneID; 102879349; -.
DR KEGG; pale:102879349; -.
DR CTD; 29911; -.
DR eggNOG; ENOG502QTJ1; Eukaryota.
DR InParanoid; L5K4R6; -.
DR OrthoDB; 50921at2759; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IEA:InterPro.
DR GO; GO:0030705; P:cytoskeleton-dependent intracellular transport; IEA:InterPro.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR008636; Hook_C.
DR InterPro; IPR043936; HOOK_N.
DR PANTHER; PTHR18947; HOOK PROTEINS; 1.
DR PANTHER; PTHR18947:SF37; PROTEIN HOOK HOMOLOG 2; 1.
DR Pfam; PF05622; HOOK; 1.
DR Pfam; PF19047; HOOK_N; 1.
DR SUPFAM; SSF116907; Hook domain; 1.
DR PROSITE; PS50021; CH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552}.
FT DOMAIN 6..122
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT COILED 180..427
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 475..604
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 717 AA; 83041 MW; CD181B1664FDDF89 CRC64;
MSVDKAELCG SLLTWLQTFH VPSPCTRPQE LSSGLAIANV LNQIDPSWFN EAWLQRISED
PGPNWRLKVS NLKIILQSLV EYSQDVLGHP ISEQHLPDVS LVGEFSDPGE LGKLLQLVLG
CAISCEKKQE HIQRIMTLEE AVQHVVMEAI QELMTKDTPD ALLPESYGNF DSQSRRYYFL
SEEADEGDEL RQRCLDMERQ LVLLSEEKQN LAQENAVLRQ QVGRPEGEGA TGLTAKKLLL
LQSQLEQLQE ENFRLESGRE DDRLRCVELE REVTELQQRN QALTSLAQEA QALKDEMDEL
RQSSERAGQL EATLSSCRRR LGELRELRRQ VRQLEECNAG HAERTRQLED ELRKAGSLRA
QLEAQRQQVQ ELQGQRQEEA MKAEKWLFEC RNLEEKYESV TKEKERLLAE RDSLREANEE
LRCAQLQPRG LTQADPSLDP TSPAVENLAA EILPAELRET LLRLQLENKR LCQQEAADRE
RQEELQRHLE EANRARHGLE TQHRLNQQQL SELRAQVEDL QKALQEQGSK TEDSTLLKRK
LEEHLQKLHE ADLELQRKRE YIEELEPPAD GSTARRIEEL QDSLQKKDAD LRAMEERYRR
YVDKARTVIQ TLEPKQRPPR GAPPELHTLR TQLREREVRI RHLEMDFEKN RSQREQEEKL
LISAWYNMGM ALQQRAGDER APAHAQSFLA QQRLATNARR GPLGRLTSLN MRSTDKH
//
