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Database: UniProt
Entry: L5K7G9_PTEAL
LinkDB: L5K7G9_PTEAL
Original site: L5K7G9_PTEAL 
ID   L5K7G9_PTEAL            Unreviewed;      1911 AA.
AC   L5K7G9;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   27-SEP-2017, entry version 24.
DE   RecName: Full=Voltage-dependent P/Q-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   ORFNames=PAL_GLEAN10002799 {ECO:0000313|EMBL:ELK06736.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Megachiroptera;
OC   Pteropodidae; Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK06736.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y.,
RA   Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y.,
RA   Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G.,
RA   Wang L.F., Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the
RT   evolution of flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1A
CC       gives rise to P and/or Q-type calcium currents. P/Q-type calcium
CC       channels belong to the 'high-voltage activated' (HVA) group and
CC       are blocked by the funnel toxin (Ftx) and by the omega-agatoxin-
CC       IVA (omega-Aga-IVA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; KB030998; ELK06736.1; -; Genomic_DNA.
DR   InParanoid; L5K7G9; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR005448; CACNA1A.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF249; PTHR10037:SF249; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01632; PQVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000010552};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     56     75       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    167    189       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    301    322       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    365    387       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    441    465       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    820    839       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    859    880       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    892    909       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    954    976       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1066   1091       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1147   1165       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1177   1200       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1268   1286       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1364   1388       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1525   1559       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      461    497       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1911 AA;  216762 MW;  655D06B54620EF36 CRC64;
     MVPMKESMEN ILATVGTEFD LRTLRAVRVL RPLKLVSGIP SLQVVLKSIM KAMIPLLQIG
     LLLFFAILIF AIIGLEFYMG KFHTTCFEEG TDDIQGESPA PCGTEEPART CPNGTKCQPY
     WEGPNNGITQ FDNILFAVLT VFQCITMEGW TDLLYNSNDA SGNTWNWLYF IPLIIIGSFF
     MLNLVLGVLS GEFAKERERV ENRRAFLKLR RQQQIERELN GYMEWISKAE EVILAEDETD
     GEQRHPFDAL RRATIKKSKT DLLNPEEAES QLADIASVEP KPREAAITRQ PDRDRNTYMR
     FLGESLVMVI IGSIFEVIWA VIKPGTSFGI SVLRALRLLR IFKVTKYWAS LRNLVVSLLN
     SMKSIISLLF LLFLFIVVFA LLGMQLFGGQ FNFDEGTPPT NFDTFPAAIM TVFQILTGED
     WNEVMYDGIK SQGGVQGGMV FSIYFIVLTL FGNYTLLNVF LAIAVDNLAN AQELTKDEQE
     EEEAANQKLA LQKAKEVAEV SPLSAASMSI AVKEQQKNQK PAKSVWEQRT SEMRKQNLLA
     SREALYNEMD PDERWKATYA RHLRPDMKTH LDRPLVVDPQ ENRNNNTNKS RAAEPTLWVL
     FHRPSFHREN QGSGVPVSGP NLSTTRPIQQ DLGRQDPPLA EDIDNMKNNK LATAESASPH
     DSLGHSGLAQ SPAKMGNSTH PGPAPAPPAT ATNPQNTTSR RMPNNPGNPS NPGPPKTPEN
     SLIVTNPSST QTNSAKTARK PDHTTVDIPP ACPAPLNHTV VQVNKNANPD PLPKKEEEKK
     EEEEDDPGED GPKPMPPYSS MFILSTTNPL RRLCHYILNL RYFEMCILMV IAMSSIALAA
     EDPVQPNAPR NNVLRYFDYV FTGVFTFEMV IKMIDLGLVL HQGAYFRDLW NILDFIVVSG
     ALVAFAFTGN SKGKDINTIK SLRVLRVLRP LKTIKRLPKL KAVFDCVVNS LKNVFNILIV
     YMLFMFIFAV VAVQLFKGKF FHCTDESKEF EKDCRGKYLL YEKNEVKARD REWRKYEFHY
     DNVLWALLTL FTVSTGEGWP QVLKHSVDAT FENQGPSPGY RMEMSIFYVV YFVVFPFFFV
     NIFVALIIIT FQEQGDKMME EYSLEKNERA CIDFAISAKP LTRHMPQNKQ SFQYRMWQFV
     VSPPFEYTIM AMIALNTIVL MMKFYGASLA YENALRVFNI VFTSLFSLEC LLKVMAFGIL
     NYFRDAWNIF DFVTVLGSIT DILVTEFGNN FINLSFLRLF RAARLIKLLR QGYTIRILLW
     TFVQSFKALP YVCLLIAMLF FIYAIIGMQV FGNIGIDVED EDSDEDEFQI TEHNNFRTFF
     QALMLLFRSA TGEAWHNIML SCLSGKPCDK NSGILTPECG NEFAYFYFVS FIFLCSFLML
     NLFVAVIMDN FEYLTRDSSI LGPHHLDEYV RVWAEYDPAA WGRMPYPDMY QMLRHMSPPL
     GLGKKCPARV AYKRLLRMDL PVADDNTVHF NSTLMALIRT ALDIKIAKGG ADKQQMDAEL
     RKEMMAIWPN LSQKTLDLLV TPHKSTDLTV GKIYAAMMIM EYYRQSKAKK LQAMREEQNR
     TPLMFQRMEP PSPTQEGGPG QNALPSTQLD PGGGLMAHES GIKESPSWVT QRAQEMFQKT
     GTWSPERGPP TDMPNSQPNS QVPLYPHCPK GLDQAIQEGG VWALCLQFQT HQAVPGVLAA
     SPGAHPALPS APQSVEMREM GRDGYSDSER YLPMEGQARA TSMPRLPAEN QTISDTSPMK
     RSASVLGPKA RRLDDYSLER VPPEENQRHH QRRRERSHRA SERSLGRYTD VDTGLGTDLS
     MTTQSGDLPP KERDQERGRP KDRKHRQHHH HHHHHHPPPP DKERYAQERQ DHRARTRDQR
     WSRSPSEGRE HMAHRQVGVA GVAPDPNMGD PEAGGTSHSP LGRVFTPHCD L
//
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