ID L5K7H8_PTEAL Unreviewed; 2278 AA.
AC L5K7H8;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Dynein heavy chain 6, axonemal {ECO:0000313|EMBL:ELK07669.1};
GN ORFNames=PAL_GLEAN10005162 {ECO:0000313|EMBL:ELK07669.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK07669.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; KB030948; ELK07669.1; -; Genomic_DNA.
DR STRING; 9402.L5K7H8; -.
DR InParanoid; L5K7H8; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 7.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF34; DYNEIN HEAVY CHAIN, CYTOPLASMIC; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552}.
FT DOMAIN 126..452
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 621..743
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 860..901
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 957..1216
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 1229..1561
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 1624..1766
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 1949..2274
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT COILED 1451..1492
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2278 AA; 259159 MW; 4EBBB75AA4C1DCFC CRC64;
MRHTLKEDVS MQVILTISQI MWCRDLTECL DEDGNQLEAL EAFEKVNFER LNALAALVRG
SLPKLHRNII TALITIDVHA RDIVTELAQA KVEEVESFDW QRQLRYYWDI DLDNCVARMA
LSQYTYGYEY LGACPRLVIT PLTDRCYLCL MGALQLDLGG APAGPAGTGK TETTKDLAKA
LAIQCVVFNC SDGLDYKMMG RFFSGLAQSG AWCCFDEFNR IDIEVLSVIA QQLITIRNAK
AAKLSRFMFE GREIKLIMTC AAFITMNPGY AGRTELPDNL KALFRPFAMM VPNYALIAEV
ILYSEGFESS KILARKMTQM YKLCSEQLSQ QDHYDFGMRA VKSVLVMAGS LKRENPDLNE
DVVLIRALRD SNLPKFLTDD ALLFSGIISD LFPGVQIPEH DYGILQSTII DVMNRQNLQP
EICMVKKVIQ FYETMLVRHG VMLVGPTGGG KTTVYQILAE TLGNLQKLGL DNPFYQPVKT
YVLNPKSITM GELYGEVNNI TLEWKDGLMA LSVRAAVNDT SEDHKWIISD GPVDALWIEN
MNTVLDDNKM LCLANSERIK LTPQVHMLFE VQDLKVASPA TVSRCGMVFV DPEELKWMPY
VKTWMERIKR KLNKETEEYI LNLFQRYVDD GLHFINKKCS QAIPQVDISK VTTLCCLLES
LILGKDGVNL TMEQTKLNSI LCQTFVFCYL WSLGGNITEN YWDSFDTFIR TQFDDNPDAR
LPSSGDLWSI HVDFDTKRLD PWERIIPTFK YSRDVPFFEM LVPTADTVRF GYLMEKLLAV
RHSVLFTGTT GVGKDVTIVS ACAPPGGGRN PVTPRFIRHF SMLCLPMPSE HSLKQIFQAI
LNGFLNDFPP AVKQTASNIV EASVEIYRRM SVDLLPTPAK SHYVFNLRDL SKCVQDKHFG
IAIDLEYFLS KPIIFGDFIK ANKSDRIYDD MPDIEKISNV LQDYLDDYNL TNPKEVKLVF
FQDAIEHVSR IARMIRQERG NALLVGVGGT GKQSLTRLAA HICGYRCLQI ELSRGYNYDT
FHEDLRKLYK LAGIDDKNMV FLFTDTQIVV EEFLEDINNI LNSGEVPNLF EKDELEQVLA
ATRPRAKEAG ISEGNRDEVF QYFISRVRQK LHIVLCMSPV GEAFRSRCRM FPSLVNCCTI
DWFVQWPREA LLSVSKTFFS NVDAVNDELK EKLSLMCVNV HLGVSNMAER YYTELRRRYY
TTPTSYLELI NLYLTMLSDK RKQLVSARER VKNGLSKLLE TNVLVDKMKL DLSALEPVLL
TKSQDVEALM DKLAVDQENA DQVRNIVQED EAMAKVKAEE TQAIADDAQR DLEEALPALD
AANKALDSLD KADISEIRVF TKPPDLVMTV MEAISILLNA KPDWPTAKQL LGDSNFLRRL
LEYDKENIKP QILAKLQKYI NNPDFVPEKV EKVSKACKSM CMWVRAMDLY SRVVKEVEPK
RQKLRAAQAE LDVTMTTLKE KQALLKQVED QIHTLQDEYD KSVNEKESLA KTMALTKARL
IRAGKLTAAL GDEQVRWEES IQKFDEEISN IIGNVFIAAA CVAYYGAFTA QYRQLLRECW
IQDCQSLEIP ISPSFSLINI LGDPYEIRQW NTDGLPRDLV STENGILVTQ GRRWPLMIDP
QDQLKEILDP ALEPILLKQT FLSGGRLLIR LGDSDIDYDK NFRFYMTTKL PNPHYLPEVC
IKVTIINFTV TKSGLEDQLL SDVVRLEKPE LEEQRIKLIV RINADKNQLK TIEDKILRML
FTSEGNILDN EELIDTLQDS KAKVPQIRVS EKYYSSFFIA IICIACLHVP FLILEGKEVS
SITSGTIKIR LKEAESTEVM INIAREKYRP IATQGSVMYF VIASLSEIDP MYQYSLKYFK
QEHPPKPDVP WLLSPMWFSC CDLEESFPVF TGLTKYILLH PIPIRLGIYF APLADSLQEF
KDYIENLPLI DDPEIFGMHE NANLVFQYKE TNSLINIILE IQPRSSSGGE GKSNDEIVQE
FVTSVQTRVP ELLEMESASE SLFIKDPQGR LNSLTTVLGQ EVDRFNSLLK LIHTSLETLD
KAIAGLVVMS EEMEKVYNSF LNNQVPSLWS NTAYPSLKPL GSWVKDLILR TSFVDLWLKR
GQPKSFWISG FFFPQGFLTG TLQNHARKYN LPIDELSFKY NMIPIYRDQA AVIEAAKTVQ
FGQELPMDIE LPSPEDGVLV HGMFMDASRW DNDEMVIEDA LPGQINPMLP VVHFEPQQNY
EPSPTLYHSP LYKTGARAGT LSTTGHSTNF VVTVLLPSKR STDYWIAKGS ALLCQLSE
//
