ID   L5K9F4_PTEAL            Unreviewed;       682 AA.
AC   L5K9F4;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   24-JAN-2024, entry version 42.
DE   SubName: Full=Rho GTPase-activating protein 22 {ECO:0000313|EMBL:ELK08339.1};
GN   ORFNames=PAL_GLEAN10004414 {ECO:0000313|EMBL:ELK08339.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC   Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK08339.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA   Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA   Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA   Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the evolution of
RT   flight and immunity.";
RL   Science 339:456-460(2013).
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DR   EMBL; KB030894; ELK08339.1; -; Genomic_DNA.
DR   AlphaFoldDB; L5K9F4; -.
DR   STRING; 9402.L5K9F4; -.
DR   eggNOG; KOG4270; Eukaryota.
DR   InParanoid; L5K9F4; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd13378; PH_RhoGAP2; 1.
DR   CDD; cd04390; RhoGAP_ARHGAP22_24_25; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR15228:SF22; RHO GTPASE-ACTIVATING PROTEIN 22; 1.
DR   PANTHER; PTHR15228; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552}.
FT   DOMAIN          19..127
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          137..331
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          334..430
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          453..484
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          527..580
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          591..667
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        355..430
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        464..481
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        556..574
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   682 AA;  74651 MW;  4C54142262231478 CRC64;
     MGEQSRSPGR LSCPQKLGPV LKAGWLKKQR SIMKNWQQRW FVLRGDQLFY YKDKDETKPQ
     GFISLQGTQV TELLPGPEDV GKHLFEISPG GAGEREKVPA NPEALLLMAS SQRDMEDWVQ
     AIRRVIWAPF GGGIFGQRLE DTVHQERKYG PRLAPLLVEQ CVDFIRERGL TEEGLFRMPG
     QANLVRDLQD SFDCGEKPLF DSTTDVHTVA SLLKLYLREL PEPVVPFARY EDFLSCAQLL
     TKDEGEGTLE LAKQVSSLPL ANYNLLRYIC KFLDEVQSHS NVNKMSVQNL ATVFGPNILR
     PQIEDPVTIM EGTSLVQHLM TVLIRRHGQL FTARATEGPA SPHGGTPCTV GWGSEEVTRD
     SQAEPSSPGT PGLPSHRTSS LDGATVAALS RNSPLGPATS SSGKRMQTLP NWKSSFRQSG
     SRSGSLKMGS SSLEVPIISS GGNWLMNGLS SLRGHRRASS GDRLKDSGSS QRLSTYDNVP
     PPSLFPSTPS VASMAWSGAS SCEASAGGSI SSCTACRASD SSACSSLHTE AGLEPSPLPS
     SSEDRRSPDL GHSQDEVGTC LSSSEPSNPG SPAQDHARRS EALQGLVTEL RAELCRQRTE
     YETSVKRLEE ASADLKKRMS WLEEELDQEK KKYTMLEIKL RNSERAREDA EKRNQLLQKE
     MEEFFSTLGS LTVGAKGAGA PK
//