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Database: UniProt
Entry: L5KD89_PTEAL
LinkDB: L5KD89_PTEAL
Original site: L5KD89_PTEAL 
ID   L5KD89_PTEAL            Unreviewed;       914 AA.
AC   L5KD89;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   24-JAN-2024, entry version 36.
DE   SubName: Full=Rap guanine nucleotide exchange factor 3 {ECO:0000313|EMBL:ELK08433.1};
DE   Flags: Fragment;
GN   ORFNames=PAL_GLEAN10010028 {ECO:0000313|EMBL:ELK08433.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC   Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK08433.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA   Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA   Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA   Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the evolution of
RT   flight and immunity.";
RL   Science 339:456-460(2013).
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DR   EMBL; KB030893; ELK08433.1; -; Genomic_DNA.
DR   AlphaFoldDB; L5KD89; -.
DR   STRING; 9402.L5KD89; -.
DR   InParanoid; L5KD89; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   CDD; cd04437; DEP_Epac; 1.
DR   CDD; cd00155; RasGEF; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 2.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF24; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 3; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF00617; RasGEF; 2.
DR   PRINTS; PR00103; CAMPKINASE.
DR   SMART; SM00100; cNMP; 1.
DR   SMART; SM00049; DEP; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS50186; DEP; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552}.
FT   DOMAIN          117..187
FT                   /note="DEP"
FT                   /evidence="ECO:0000259|PROSITE:PS50186"
FT   DOMAIN          246..347
FT                   /note="Cyclic nucleotide-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50042"
FT   DOMAIN          607..880
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ELK08433.1"
SQ   SEQUENCE   914 AA;  102706 MW;  519BB9885ECFAD78 CRC64;
     WSQVGWPGES RWQVGLTVED SPALGAPQVG GLPDVVPEGT LLNMVLRRMH RPRSCSYQLL
     LEHQRPSRIQ GLRWTPLTNS EESLDFSVSL EQASTERVLR AGKQLHRHLL ATCPNLIRDR
     KYHLRLYRQC CSGRELVDGI LALGLGVHSR SQAVGICQVL LDESALCHVK HDWTFQDRDT
     QFYRFPGPEP EPVGVHELEE ELVEAMALLS QRGPDALLTV ALRKSPGQRT DEELDLIFEE
     LLHIKAVAHL SNSVKRELAA VLLFEPHSKA GTVLFSQGDK GTSWYIVWKG SVNVVTHGKG
     LVTTLHEGDD FGQLALVNDA PRAATIVLRE DNCHFLRVDK QDFNRIIKDV EAKTMRLEEH
     GKVVLVLERT SQGAGSSCPP TPGRNRYTVM SGTPEKILEL LLEAMRPDSS AHDPTGGSEQ
     ERSTYICNKR QQILRLVSQW VALYGPMLHT DPVASSFLQK LSDLVSRDAR LSNLLREQWP
     ERRRHHSQDE PLPSSNCAIR VGDKVSYDIC RPDHSVLTLQ LPVMASVREV MAALAKEDSW
     TKGQVLVKVN SAGDAIGLQP DARGVATSLG LNERLFVVNP QEVHELTPHP EQLGPTVGSA
     EGLDLVSAKD LAGQLTDHDW NLFNSIHQVE LIHYVLGPQH LRDVTTANLE RFMRRFNELQ
     YWVATELCLC AVPGPRAQLL RKFIKLAAHL KEQKNLNSFF AVMFGLSNSA ISRLARTWEV
     GVTWRGRPGP HPPAQGQSPC LSWESCWGRG SHLRAVTAPS ASPSQRLPHK VRKLYSALER
     LLDPSWNHRV YRLALTKLSP PVIPFMPLLL KDMTFIHEGN HTLVENLINF EKMRMMARAV
     RMLHHCRSHS NVPLSPLRSR VSHLHEDSQA VRISTCSEQS LSTRSPASTW AYVQQLKVID
     NQRELSRLSR ELEP
//
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