ID L5KD89_PTEAL Unreviewed; 914 AA.
AC L5KD89;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE SubName: Full=Rap guanine nucleotide exchange factor 3 {ECO:0000313|EMBL:ELK08433.1};
DE Flags: Fragment;
GN ORFNames=PAL_GLEAN10010028 {ECO:0000313|EMBL:ELK08433.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK08433.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
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DR EMBL; KB030893; ELK08433.1; -; Genomic_DNA.
DR AlphaFoldDB; L5KD89; -.
DR STRING; 9402.L5KD89; -.
DR InParanoid; L5KD89; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd04437; DEP_Epac; 1.
DR CDD; cd00155; RasGEF; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF24; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 3; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00617; RasGEF; 2.
DR PRINTS; PR00103; CAMPKINASE.
DR SMART; SM00100; cNMP; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552}.
FT DOMAIN 117..187
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 246..347
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 607..880
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ELK08433.1"
SQ SEQUENCE 914 AA; 102706 MW; 519BB9885ECFAD78 CRC64;
WSQVGWPGES RWQVGLTVED SPALGAPQVG GLPDVVPEGT LLNMVLRRMH RPRSCSYQLL
LEHQRPSRIQ GLRWTPLTNS EESLDFSVSL EQASTERVLR AGKQLHRHLL ATCPNLIRDR
KYHLRLYRQC CSGRELVDGI LALGLGVHSR SQAVGICQVL LDESALCHVK HDWTFQDRDT
QFYRFPGPEP EPVGVHELEE ELVEAMALLS QRGPDALLTV ALRKSPGQRT DEELDLIFEE
LLHIKAVAHL SNSVKRELAA VLLFEPHSKA GTVLFSQGDK GTSWYIVWKG SVNVVTHGKG
LVTTLHEGDD FGQLALVNDA PRAATIVLRE DNCHFLRVDK QDFNRIIKDV EAKTMRLEEH
GKVVLVLERT SQGAGSSCPP TPGRNRYTVM SGTPEKILEL LLEAMRPDSS AHDPTGGSEQ
ERSTYICNKR QQILRLVSQW VALYGPMLHT DPVASSFLQK LSDLVSRDAR LSNLLREQWP
ERRRHHSQDE PLPSSNCAIR VGDKVSYDIC RPDHSVLTLQ LPVMASVREV MAALAKEDSW
TKGQVLVKVN SAGDAIGLQP DARGVATSLG LNERLFVVNP QEVHELTPHP EQLGPTVGSA
EGLDLVSAKD LAGQLTDHDW NLFNSIHQVE LIHYVLGPQH LRDVTTANLE RFMRRFNELQ
YWVATELCLC AVPGPRAQLL RKFIKLAAHL KEQKNLNSFF AVMFGLSNSA ISRLARTWEV
GVTWRGRPGP HPPAQGQSPC LSWESCWGRG SHLRAVTAPS ASPSQRLPHK VRKLYSALER
LLDPSWNHRV YRLALTKLSP PVIPFMPLLL KDMTFIHEGN HTLVENLINF EKMRMMARAV
RMLHHCRSHS NVPLSPLRSR VSHLHEDSQA VRISTCSEQS LSTRSPASTW AYVQQLKVID
NQRELSRLSR ELEP
//