ID L5KEX6_PTEAL Unreviewed; 1712 AA.
AC L5KEX6;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=GPI ethanolamine phosphate transferase 3 {ECO:0000256|ARBA:ARBA00020841};
GN ORFNames=PAL_GLEAN10008256 {ECO:0000313|EMBL:ELK09048.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK09048.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
CC {ECO:0000256|ARBA:ARBA00008695}.
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DR EMBL; KB030846; ELK09048.1; -; Genomic_DNA.
DR STRING; 9402.L5KEX6; -.
DR eggNOG; KOG2126; Eukaryota.
DR InParanoid; L5KEX6; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051377; F:mannose-ethanolamine phosphotransferase activity; IEA:InterPro.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd16023; GPI_EPT_3; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR002591; Phosphodiest/P_Trfase.
DR InterPro; IPR037675; PIG-O_N.
DR InterPro; IPR039524; PIGO/GPI13.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR23071:SF1; GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3; 1.
DR PANTHER; PTHR23071; PHOSPHATIDYLINOSITOL GLYCAN; 1.
DR Pfam; PF01663; Phosphodiest; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ELK09048.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 448..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 476..502
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 509..526
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 538..560
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 572..589
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 667..687
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 702..721
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 733..759
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 830..849
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 856..880
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 990..1010
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1022..1044
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT COILED 1373..1403
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1712 AA; 188130 MW; 6104FF7A62528FD9 CRC64;
MQKISVLLFL VWICFLFYAG IALFTSGFLL TRLELTNHSS CQEPPGPGSL PWGSQREPRA
CWMDSRFSRL VLVLIDALRF DFVQPQRSNV PGETSVSLPF LGKLGSLQRI LEIQPHHARL
YQSKADPPTT TMQRLKALTT GSLPTFIDAG SNFASYAIVE DNLIKQLISA GRRVVFMGDD
TWKDLFPGAF SQAFFFPSFN VRDLHTVDNG ILEHLYPTMD SGGWDVLIAH FLGVDHCGHK
HGPHHPEMAK KLSQMDQVIQ GVVERLENDT LLVVIGDHGM TKNGDHGGDS ELEISAALFL
YSPTALFHRA PPEEPEVIPQ VSLVPTLALL LGLPIPFGNI GEVIVELFAE VEDSQPHSSA
LAQASALHLN AQQVSRFLHT YSAATQDLQV TELRRLHNLF SKASADYQRL LQSPQGAEAA
LQTVITELQQ FLRGVRALCI ESWARFSLVR MAGGAALLAA ACFLCLLVSQ WATSPGFYLC
PLLVLVAWGL AGVILCAGLL AITGLKLDPV VLGAMAAVGS LVPFLWKAWA GWGSKRPLVA
LLPIPGPVLL FLLIRFAALF SDSFVVAEAR ATRFLLGSFI LLLVAQLHWE GKLLPPKLLT
IPRLGFSTPT APPRHNSMQA LGLGVTLLLC IRLAEFFHRC PEETPVCHSS PWLSPLASTV
GGRAKNLWYG ACVGALVALL VVVRLWLRRY GNLKSPEPPV LFVRWGLPLM VLGTAAYWAL
ASGADEAPPR LRALVAGASV VLPRAVAGLA ASGLMLLLWR PVTVLVKATM GAPRTRTVLT
PFSGPPTSQA DLDYVVPQIY RHMQEEFRDR LERSKSQGPL TVAAYKLGSV YSAAMVTALT
FLAFPLLLLH AERISLVFLL LFLQSFLLLH LLAAGIPITI PGPFTVPWQA VSAWALMATQ
TFYATGHQPV FPAIHWNAAF VGFPEGHGSS TWLPALLVGA NTFASHLLFA GNEAEARVRP
EEEEEPLMEM RLRDSPHHFN VALLQLGLKY LFVLGIQILA CALSASILRR HLMVWKVFAP
KFIFEAMGFI VSSVGLCLGL ALVMRVDGAV SSWFRQLVLA QQRTPFALHF YGALTSFPPH
VVFYETYFHN IPLDSLVPQA NCLDLWRDKN DQLVRQAKVA QDLGLPLRRQ QLAQDALEGL
RGLLDSLQGL PAAVPVLPLE LTVICNFITL RASLAQSFTE DQAQDIQRGL ERVLETQEQL
GPRLECGLRG LWSSVLCASS LLPELLPALH HLAGLQIALW LSTDCLGDLT LLLQTLNDSQ
SKASEDLLML LKTWSPPAKE SNAPLTLQDA WGLRDVLLTA SAYRQGLQEL ITGSLPRALS
SLHEAASGLC SRPVLVQVYT ALGTCLRKMG SPQRALLYLV AALKGGSTWG PPLMEASRLY
RQLENTAAEL ESLELLVEAL SITHSSEVSH LLIGVELLLP QPDPASPLHC GTQSQVKHLL
ASRCLQTGRA EDAAEHYLDL LALLLDDSEP KFFPPPCPPG PCMPEVFLEA AAALIQAGRA
QDALTICEEL FSRTSFLLPK MPWLWEDARK GTKESSHCPP WVSAMHLLQG QAWVRLGAQK
EAISEFSRCL ELLFQDTPKD KEQGPASNCE QGCTSDMALQ QLRAAALISR GLEWVASDQD
TKALQDFLLS IQVCPGNQDA SFHLLQTLRK LDRRHEATAL WRRLEAQTKL PQENATWCVP
LYLETCLSWI HPPDRETLLE EFRTSVLETC DL
//
