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Database: UniProt
Entry: L5KRR8_PTEAL
LinkDB: L5KRR8_PTEAL
Original site: L5KRR8_PTEAL 
ID   L5KRR8_PTEAL            Unreviewed;      1668 AA.
AC   L5KRR8;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   25-OCT-2017, entry version 29.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   ORFNames=PAL_GLEAN10001281 {ECO:0000313|EMBL:ELK13651.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Megachiroptera;
OC   Pteropodidae; Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK13651.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y.,
RA   Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y.,
RA   Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G.,
RA   Wang L.F., Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the
RT   evolution of flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; KB030621; ELK13651.1; -; Genomic_DNA.
DR   InParanoid; L5KRR8; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028821; Na_channel_a11su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   PANTHER; PTHR10037:SF210; PTHR10037:SF210; 4.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000010552};
KW   Ion channel {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000313|EMBL:ELK13651.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    162    181       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    193    211       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    252    273       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    279    298       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    391    410       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    538    556       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    568    590       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    650    677       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    726    754       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1042   1061       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1084   1110       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1166   1188       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1250   1268       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1280   1302       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1314   1332       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1380   1402       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1414   1436       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1463   1487       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      174    427       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      538    763       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      772    963       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      990   1191       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1248   1497       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   1668 AA;  190093 MW;  E78541A92E9782CF CRC64;
     MRDSRLGGLQ AKLNAEDQHD FHRLFSSELL LPKGLRLPGA GSSDSEESFK RYHWGCCLEP
     RYQKADARNF RPFTSDSLAA IEKRIAIQKE KKELKDPTAA EPQPRPQLDL KASRKLPKLY
     GDIPHELIAK PLEDLDPFYR NHKTFMVLNK KRTIYRFSAK RALFIFGPFN SIRSLAIRIS
     VHSYPFVAYF TKSSMFIICT VIINCMFMAA ARGGKNNSSI ETDRAEFVSC SPNIRLSDIS
     LSSLRTFRVF RALKAISVVS GLKVIVGALL RSVKKLVDVM ILTLFCLSIF ALVGQQLFMG
     NLNQMCVRED CKNATNLDDY CYEKKDSTEF KICNSGRSDC SEKFECIHTQ KNPDYGYTNF
     DNFGWSFLAM FRLMTQDSWE KLYRQTLRTS GLFAVFFFVV VIFLGSFYLI NLTLAVVTMA
     YEEQNKNVAA ETEAKEKMFQ EAQQLLKEEK EPYLLEQTKR LSQNLSVDFC EEHRDPLQRQ
     RALSAVSILT ITMQEQEKSQ EACFPCGENL ASRYLVWDCS PRWICFKKAL RTVMTDPFTE
     LAITICIIIN TIFLAMEHHK MDQSFERILY TGNLVFTGIF TAEMCLKIIA LDPYHYFRRG
     WNVFDSIVAL LSVTDVMMNK INVPLFHSLR VLRVFKLAKS WPTLNTLIKI IGHSVGALGN
     LTVVLAIVVF IFSVVGMQMF GSKFNSEKCP RRWHMGDFYH SFLVVFRILC GEWIENMWEC
     MQNVGNAQLC IVVFLLIMVI GKLVVLNLFI ALLLNSFSNE ERDGNSEGEA KKTKVQLALD
     RFHRAFCFVL HTLEHFCCKR YRRQNLPKQK EVAGGSSAES KDVIPLVTEV KKGPETWEEF
     SVLTSAPKTL VVGHDWTWLA PLAEEEDDIE SPEEDNAQPV TQPEAGKQAH ELHQEAKSSS
     PRVQNVEIDV FSEDDAYLSV QNPRKKSDAI SVFSECSTID LQDPFRRVPE MVPQKEPERC
     LPKEPGGCET PLVPSNKADF FLAFSVCSNV LVFEDVNLHK QPNIQALLNC TDNIFTFIFI
     MEMGLKWVAF GFWKYFTSAW CWLDFIIVIV SVLNLTNLKV LKSLRTLRAL RPLRALSQFE
     GMKVVVNALI GAIPAILNVL LVCLIFWLIF CILGVNLFSG KFGRCTNVTD NSSLVIDPKL
     VANLSQCESR NFTWVNLNVN FDNVGMAYLA LLQVATFKGW MEIMYAAVDS NEVMPRKGLS
     LSPYPVWFHV LQTSNQRGVE PRMPSHALSN SSLFENKCQG LVFDLVTNQI FDVIIIILII
     LNMVSMMAES DNQSKTMSLI LDYLNLAFVV IFTIECLIKI FALRQYYFTN GWNLFDCVIV
     VLSIVSMMIS ALEEQKHIPF PPTLFRIVRL ARIGRILRLV RAARGIRTLL FALMMSLPSL
     FNIGLLLFLI MFIYAIFGMS WFCKVKPDSG IDDIFNFQTF AGSLLCLFQI TTSAGWDTLL
     SPMLQSDDSC NSTSENCYLS TTAISYFVSY IIISFLIVVN MYIAVILENF NTATEESEDP
     LGEDDFEIFY EVWEKFDPEA TQFIKYSALS DFADALPEPL RVAKPNKFQF LVMDLPMVTG
     DRLHCLDILF AFTTRVLGDS NGLDSMKAMM EEKFMEANPF KKLYEPIVTT TKRKEEERCA
     AVIQKAFRKY MMKVTMSTLE DRPRSPLQTP CNGSLSSSGV AEGKVHCD
//
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