ID L5KRV4_PTEAL Unreviewed; 322 AA.
AC L5KRV4;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Transmembrane and ubiquitin-like domain-containing protein 2 {ECO:0000313|EMBL:ELK14162.1};
GN ORFNames=PAL_GLEAN10004234 {ECO:0000313|EMBL:ELK14162.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK14162.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KB030578; ELK14162.1; -; Genomic_DNA.
DR RefSeq; XP_006910171.1; XM_006910109.2.
DR RefSeq; XP_015443526.1; XM_015588040.1.
DR RefSeq; XP_015443527.1; XM_015588041.1.
DR AlphaFoldDB; L5KRV4; -.
DR STRING; 9402.L5KRV4; -.
DR GeneID; 102889140; -.
DR KEGG; pale:102889140; -.
DR CTD; 79089; -.
DR eggNOG; ENOG502QU8U; Eukaryota.
DR InParanoid; L5KRV4; -.
DR OrthoDB; 2882776at2759; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IEA:InterPro.
DR CDD; cd17132; Ubl_TMUB2; 1.
DR InterPro; IPR040352; TMUB1/2.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR14557; PROTEIN C7ORF21; 1.
DR PANTHER; PTHR14557:SF4; TRANSMEMBRANE AND UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF00240; ubiquitin; 1.
DR SMART; SM00213; UBQ; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Transmembrane {ECO:0000256|SAM:Phobius, ECO:0000313|EMBL:ELK14162.1};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 38..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..289
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 301..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 174..247
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000259|PROSITE:PS50053"
FT REGION 88..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 145..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..116
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 322 AA; 33973 MW; 6B7CEFDFFAD3A21F CRC64;
MISRHLQNNL MSVDPVSSQA MELSDVTLIE GVGNEVTVVA GVVVLILALV LAWLSTYVAD
SGSNQLLGTI VSAGDTSVLH LGHVDHLVAG QGTPEPTELP HPSEGNDEKA EEAGEGGGDS
TGEPGAGSGI EPSLEHLLDI QGLPKRQAGP ESSSPEDPLR SEDSTCLPPS PGLINVRLKF
LNDTEELAVA RPEDTVGALK SKYFPGQESQ MKLIYQGRLL QDPARTLRSL NITNNCVIHC
HHSPPGSAVP GPSASLASTS ATEPPSLGVS VGSLMVPVFV VLLGVVWYFR INYRQFFTAP
ATVSLVGVTV FFSFLVFGMY GR
//
