ID L5KSB5_PTEAL Unreviewed; 456 AA.
AC L5KSB5;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=SH2B adapter protein 3 {ECO:0000313|EMBL:ELK14339.1};
GN ORFNames=PAL_GLEAN10008868 {ECO:0000313|EMBL:ELK14339.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK14339.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SIMILARITY: Belongs to the SH2B adapter family.
CC {ECO:0000256|ARBA:ARBA00010220}.
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DR EMBL; KB030576; ELK14339.1; -; Genomic_DNA.
DR AlphaFoldDB; L5KSB5; -.
DR STRING; 9402.L5KSB5; -.
DR eggNOG; ENOG502QS89; Eukaryota.
DR InParanoid; L5KSB5; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0035591; F:signaling adaptor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd10412; SH2_SH2B3; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR030523; SH2B.
DR InterPro; IPR035059; SH2B3_SH2.
DR PANTHER; PTHR10872; SH2B ADAPTER PROTEIN; 1.
DR PANTHER; PTHR10872:SF1; SH2B ADAPTER PROTEIN 3; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 253..351
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 198..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 386..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 421..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..444
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 456 AA; 50394 MW; FB38082780E452D1 CRC64;
MMQYWPGRAY WEVAHRPPVW PYIPLGFSMA TVKTRLVLLL HSLTLHKTVA TFFKRQTWLL
HLGLRHERAR PAASLGLFHA LRRLVRDAVP AGLERVLRAA RGGHGPGAGP AVLALRPRAP
TARAAARRAG VAASSKPKLQ AACSSIQEVR RCTRLEMPDN LYTFVLKVKD RTDIIFEVGD
EQQLNSWMAE LRECTGQGLE STEPEMHIPS ALEPGTSSSP RGSTDSLNQG ASLGGLLDPA
CQKTDHFLSC YPWFHGPISR VKAAQLVQLQ GPAAHGVFLV RQSETRRGEY VLTFNFQGIA
KHLRLSLTER GQCRVQHLHF PSVVDMLHHF QRSPIPLECG AACDVRLSSY VVVVSQPPGS
SNTVLFPFSL SRWDSELGLP HLSSSGCPRG LGPEGLPGRS SPPEQIFHLV PSPEELADSL
RHLEPEPASR ARDSDYEMDS SSRSHLRAID NQYTPL
//
