ID L5KSM9_PTEAL Unreviewed; 1262 AA.
AC L5KSM9;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=RIMS-binding protein 2 {ECO:0000313|EMBL:ELK14245.1};
GN ORFNames=PAL_GLEAN10008721 {ECO:0000313|EMBL:ELK14245.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK14245.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SIMILARITY: Belongs to the RIMBP family.
CC {ECO:0000256|ARBA:ARBA00010749}.
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DR EMBL; KB030576; ELK14245.1; -; Genomic_DNA.
DR AlphaFoldDB; L5KSM9; -.
DR STRING; 9402.L5KSM9; -.
DR eggNOG; KOG3632; Eukaryota.
DR InParanoid; L5KSM9; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR CDD; cd00063; FN3; 3.
DR CDD; cd12014; SH3_RIM-BP_1; 1.
DR CDD; cd12012; SH3_RIM-BP_2; 1.
DR CDD; cd12013; SH3_RIM-BP_3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 3.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR035753; RIM-BP_SH3_2.
DR InterPro; IPR035755; RIM-BP_SH3_3.
DR InterPro; IPR040325; RIMBP1/2/3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR14234; RIM BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR14234:SF18; RIMS-BINDING PROTEIN 2; 1.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00326; SH3; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF50044; SH3-domain; 3.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50002; SH3; 3.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 183..250
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 408..490
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 504..605
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1005..1072
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1108..1197
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 87..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 115..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 605..681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 707..793
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 826..868
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 886..929
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 948..1005
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1..67
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 115..129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..155
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 620..634
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 707..733
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 743..763
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 886..915
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1262 AA; 136945 MW; 025602E3019476AE CRC64;
MREAAERRQQ LELEHEQALA ALTAKQQEID LLQKAQLEAK REHEGAVQLL ECRVRELEER
CRAQSEQFGL LSRDLEKFRQ HAGRIDLLGS STAPSDGPPP PSKPFPRFMN GLAPSIGTGQ
ESSIGSRTAT GDHIRPLLPP GDKPEPPPAR PAFPSGPGSP RCGFESDMDN ERGSSTCRQR
YSGKVHLCVA RYSYNPFDGP NENPEAELPL TAGKYLYVYG DMDEDGFYEG ELLDGQRGLV
PSNFVDFVQD SESRLGTLAT GQDQNLINLS GIGPEAENIL DLHSPTPPDS GVTDNSTGTL
AADVDDVGED TVPYPRKITL IKQLARSVIV GWEPPALPPG WGAGSSYSVL VGQEPRLSLP
LAGRTKALVE KLDMAAGTYR VSVQCVTGRG SSDPLRCTLL VGKDVVVAPS QLRVDNVTQT
SAQLSWLPTN SNYSHVIFLN EEELGVVGAA RYKFPLFNLR PSVAYKVKVL ARPHQMPWQL
PLEQREKKEA FVEFATLPAG PPAPPRDVTV QAGATPATIR VSWQPPALTT TGLSSGASVT
GYGVYAKGQR VAEVSAPTAD SATVELPRLR SLDAKAVTVR TLSAQGESTD SAIAAIPPAL
LVPPAPTPKP LASAGVPDTK DDRLGPHVKV DEAWEQSRAP VPVHGHMLGP PSLQGPGRRS
PSPSRILPQP QGAPVSTSVA RAMARKAAER VAESSRLEKR SVFAERGAQY ADSDEEDGYE
SPDAKRRGAS VDDFLKGSEL GKPPHCCHGE EYHTESSRGS DLSDIMEEDE EELCSEMQLE
DGGRRRPSGT SHSALKKLTD KIGFFLIAEV ASKNFLLVPP RPQKAWVEGS RSGRWATRSP
DSGLDCGSDE ELRSSSRNAA AKRSPGPGLC PCRSLRPLLA RRRTLTRQSS IEEDFGEQVD
PGDVIRSDDA HPSPEGPAPR KYGWDEPAGP EDLRDVWKKS ILGSVASAGR AERADHVGRR
FSRGSAGTRR SPPGMVPAIG DYGGRDRLSP DLYEESETDP GADEPPARIF VALFDYDPLS
MSPNPDAAEE LPFKEGQIIR VYGDKDADGF YRGETCARLG LIPCNMVSEI QADDDEMMDQ
LLRQGFLPLN TPVEKTERNR RGGRPRPVPT RRAVALYDYD PRESSPNIDA EAELTFCTGD
IITVFGEIDE DGFYYLKPGV GFGENSQRLR GLTLCSQGEL NGQKGLVPSN FLEEVPDDVE
VYLSDVPSRP AQEPPPRAKA KRYGCPKGQR GDVWFTQSVS RVCSWADLRI ALLALPGNSA
AR
//
