ID   L5KTG6_PTEAL            Unreviewed;       492 AA.
AC   L5KTG6;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=THUMP domain-containing protein 2 {ECO:0000313|EMBL:ELK14759.1};
GN   ORFNames=PAL_GLEAN10021319 {ECO:0000313|EMBL:ELK14759.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC   Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK14759.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA   Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA   Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA   Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the evolution of
RT   flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC       {ECO:0000256|ARBA:ARBA00008361}.
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DR   EMBL; KB030567; ELK14759.1; -; Genomic_DNA.
DR   AlphaFoldDB; L5KTG6; -.
DR   STRING; 9402.L5KTG6; -.
DR   eggNOG; ENOG502QSR4; Eukaryota.
DR   InParanoid; L5KTG6; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0034470; P:ncRNA processing; IEA:UniProt.
DR   GO; GO:0009451; P:RNA modification; IEA:UniProt.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   CDD; cd11715; THUMP_AdoMetMT; 1.
DR   Gene3D; 3.30.2130.30; -; 2.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR000241; RlmKL-like_Mtase.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR004114; THUMP_dom.
DR   PANTHER; PTHR14911; THUMP DOMAIN-CONTAINING; 1.
DR   PANTHER; PTHR14911:SF1; THUMP DOMAIN-CONTAINING PROTEIN 2; 1.
DR   Pfam; PF02926; THUMP; 1.
DR   Pfam; PF01170; UPF0020; 1.
DR   SMART; SM00981; THUMP; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   SUPFAM; SSF143437; THUMP domain-like; 1.
DR   PROSITE; PS51165; THUMP; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00529};
KW   Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT   DOMAIN          162..255
FT                   /note="THUMP"
FT                   /evidence="ECO:0000259|PROSITE:PS51165"
SQ   SEQUENCE   492 AA;  54655 MW;  17E55202ADE79154 CRC64;
     MMLVARFFCT VGRGLEPFLM QEVRARLEAT QVEYISGKVF FTTSSDLNVL KTLKSAERLF
     LLIKKQFPFN VSSVSKGKMF SEMQTLINDD PESWLNAISI WKSLLELDAE KEKLSQRHAN
     PLKRKLGEND TIISKKLKTE QMQATQEIGD CPLEKQIEEE TLEQGNLLPK RETFQEEFQN
     GIAKAVNTHN QNGLTFRVSC RCSGTVAKTF TAQEVGRIIG IALMKQFGWK ADLRNPNLEI
     FIHLNDMYSV VGIPVFRVPL ASRAYIKTAG LRSTVAWAMA SVAEIKAGMF VLDPMCGLGT
     ILLEAAKEWP DVYYVGADVS NSQLLGACDN LKAAGLKDKI ELLKVSVIEL PLPSESVDII
     ISDIPFGKKF KLGKDIKSIL QEMERVLHVG GTVVLLLSKD HHRHIEDCEG GGIPLNSKGS
     HTDVRGIEKC LIPEEKTGIS ETVPSSSEPS NRECLDKVPP FGSLVPMECY KVSLGRTDAF
     ICKYKKSHSS GL
//