ID L5KUF8_PTEAL Unreviewed; 2330 AA.
AC L5KUF8;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=Spectrin alpha chain, erythrocyte {ECO:0000313|EMBL:ELK14596.1};
GN ORFNames=PAL_GLEAN10000606 {ECO:0000313|EMBL:ELK14596.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK14596.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex
CC {ECO:0000256|ARBA:ARBA00004544}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the spectrin family.
CC {ECO:0000256|ARBA:ARBA00006826}.
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DR EMBL; KB030569; ELK14596.1; -; Genomic_DNA.
DR STRING; 9402.L5KUF8; -.
DR eggNOG; KOG0040; Eukaryota.
DR InParanoid; L5KUF8; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.
DR CDD; cd00176; SPEC; 9.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.58.60; -; 19.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR014837; EF-hand_Ca_insen.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF422; SPECTRIN ALPHA CHAIN; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF08726; EFhand_Ca_insen; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF00435; Spectrin; 19.
DR PRINTS; PR01887; SPECTRNALPHA.
DR SMART; SM01184; efhand_Ca_insen; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00150; SPEC; 19.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 17.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Actin capping {ECO:0000256|ARBA:ARBA00022467};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 968..1027
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 2182..2217
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 2225..2260
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT COILED 858..889
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2012..2046
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2330 AA; 269827 MW; 936885F8B065596D CRC64;
MESVGPKVLE TAEEIQERRQ EVLTRYQRFK ELVAERGQKL EDSYHYQVFR RDADDLEKWI
LEKLKIAEDK SYEDPTNIQG KYQKHESFEA EVQAKSRVIP ELEEISKVRF AEGHFAHEDT
KVHLEELRHL WDLLLELTRE KGILLLQALK LQQYLQECAD ILEWIGDKEA IVTSVELGED
WERTEVLHKK FEEFQVDLAA RKGRVDRVNQ YANQCAEENH PELPLIKLKQ DEVNVSWERL
HGLALQRQRT LSNAADLQRF KRDVTEAIQW IKEKEPQLTS EDYGKDLVSS EALFHSHKGF
ERNLAVMDDK VKELCAKADK LRLSHPSDAP QIQQMKEDLV SNWEHIRALA TSRYTKLQAS
YWYQRFLSDY NELSGWMKEK TALINADELP TDVAGGEALL DRHQQHKHEI DSYDDRFQSA
DETGQALLDA NHEASDEVLE KMAILDNNWA ALKELWVRCH HQYEQCLNLH LFYRDSEQVD
NWMSRQEAFL ENEDLGNSLG SVKALLQKHD DFEEAFTAQE EKITTLDKTA TKLIDNGHYD
SENIADIRDG LLARRDVLRE RAVTRRRLLE DSLLLQQLYQ DSDDLKNWIN KKKKLADDED
YKDTQNLKSR VQKQQVFEKE LAANKILLNN LEKTGQEMTE GGHYASDSVA ARVSEVESLW
KELLEATAQK GTQLYEANQQ LQFENNAEDL KCWLVDAEKQ ATSEDYGKGL ADVQNLLRKH
SLLESGVAAR QDQVDILTDL ATYFEETGHP DAGDVRARQE NLVSQFEALK EPLATRKKKL
IDLLRLQQIC RDTEDEEAWI QETEPSAAST YLGKDLIASK NLLNRHEVIQ ADIASHELHI
RVITERGNKM VEEGHFASKD VASRVKSLNE NMESLQARAA RRQNDLEANV QFQQYLADLH
EAEAWIREKE PIVENTNYGA DEEAAGALLK KHEAFLVDLN AFGKSMQALR DQAEVCQQQQ
AAPVERVARE ERVVALYDFQ ARSPREVTLK KDDVLTLLSS INKDWWKVEA DDHQGFVPAV
YIRKLAHDEF PMLPQQRREE PVNITECQEQ IENQYHSLLD QAEECKCRLL QCYNEFLLAY
EAEDMLDWIR DKKAENTGVD LDDVWELQKK FDEFQTDLKT NEPRLRDINK VADDLLFEEL
LTPEGAQIQQ ELNARWSSLQ RLAEEQRQLL GSAHAVQMFH READDMKEQI KKKCQALSAA
DPGSDLFSVQ ALQRQHENFE RDLIPLREKV IVLGETAERL NESHPDATDD LQRQRMELNE
AWNDLLECTE DRKENLSEAK KFYLFLSKAR DLQNWISGLS GMVSSQELAE DLTGTEILME
RHQEHRADME AEAPTFQALE DFGAELIGSG HYGRPEIEEK LHAVRLERNN LDKAWERRKK
MLDQCLELQL FKGNSDQAES WMMARENFLR SDDKGSLDSL EALRKKRDDL DKAVTAQEKK
ITELEHFAER LIADDHYAKE DIAARLQWIL DRKYLKHQAF ENEVYSRADQ MEGVISLGNS
LIERRACDGN EETMKGQLEE LEKHWDYLLE RTIDKGQKLN EASRQQRFNT GIRDFEFWLS
EAETLLAMKD QARDLASAGN LLKKHQLLET EMLAREDALR DLNELATDLL SSGTFNADQI
VEKRDNVNKR YLDVQNLAAA HHEKLKEAYA LFQFFQDLDD EESWIEEKLV RVSSQDYGRD
LQGVQNLLKK HKRLDGELMA HEPAIQNVLA MAERLGDKAA VGREEIQERL AQFVQHWEKL
KMLAKARGLQ LEESLEYLQF MENAEEEETW ISEKKAMIAR GDSGDTLAAT QSLLKKHEAL
DNDFAVHEAR VQNVCAQGEG ILSQEENQHK EKISVKIEAL NEKTPSLAKA IAAWKLQLED
DYSFQQFNWK VDVVEAWIAE KETSLKTNGN GADLAAFLTL LAKQDTLDVS LHSFQQERLS
KITNLKDQLV ASQHSQSKAI EERYAALLRH WDQLLEASAA HKDKLLEKRL PLQKAEELFM
EFAHKASAFN HWCENTEEDL SEPVHCVSLN EIRQLQKDHE AFLASLARAQ EDLNFLRELN
QQIKTLNVSS SPYTWLTMEV LERIWKHLTD LIKEREQELQ KEESRQLKNF EMCQEFEQNA
SAFFQWILET RSLLKETGTL ESQLEANKDL GDNLEEALIL DIKYSTIGLA QQWDQLYQLG
MRMQHNLEQQ IQAKDTIGVS EETLKEFSTT YKHFDENLTG RLSHKDFRSC LRGLNYYLPM
VEEGEPEPKF EKFLDAVDPG RKGYVSLEDY TSFLIDKESE NIKSSDEIEN AFQALAEGKA
YITKEDMKQA LTPDQVSFCA SHMQQYVDPR GRSHLAGYDY VGFTSSYFGT
//