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Database: UniProt
Entry: L5KUF8_PTEAL
LinkDB: L5KUF8_PTEAL
Original site: L5KUF8_PTEAL 
ID   L5KUF8_PTEAL            Unreviewed;      2330 AA.
AC   L5KUF8;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   24-JAN-2024, entry version 39.
DE   SubName: Full=Spectrin alpha chain, erythrocyte {ECO:0000313|EMBL:ELK14596.1};
GN   ORFNames=PAL_GLEAN10000606 {ECO:0000313|EMBL:ELK14596.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC   Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK14596.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA   Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA   Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA   Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the evolution of
RT   flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex
CC       {ECO:0000256|ARBA:ARBA00004544}. Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245}.
CC   -!- SIMILARITY: Belongs to the spectrin family.
CC       {ECO:0000256|ARBA:ARBA00006826}.
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DR   EMBL; KB030569; ELK14596.1; -; Genomic_DNA.
DR   STRING; 9402.L5KUF8; -.
DR   eggNOG; KOG0040; Eukaryota.
DR   InParanoid; L5KUF8; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.
DR   CDD; cd00176; SPEC; 9.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.20.58.60; -; 19.
DR   Gene3D; 1.10.238.10; EF-hand; 2.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR014837; EF-hand_Ca_insen.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR018159; Spectrin/alpha-actinin.
DR   InterPro; IPR002017; Spectrin_repeat.
DR   PANTHER; PTHR11915:SF422; SPECTRIN ALPHA CHAIN; 1.
DR   PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR   Pfam; PF08726; EFhand_Ca_insen; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   Pfam; PF00435; Spectrin; 19.
DR   PRINTS; PR01887; SPECTRNALPHA.
DR   SMART; SM01184; efhand_Ca_insen; 1.
DR   SMART; SM00326; SH3; 1.
DR   SMART; SM00150; SPEC; 19.
DR   SUPFAM; SSF47473; EF-hand; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   SUPFAM; SSF46966; Spectrin repeat; 17.
DR   PROSITE; PS50222; EF_HAND_2; 2.
DR   PROSITE; PS50002; SH3; 1.
PE   3: Inferred from homology;
KW   Actin capping {ECO:0000256|ARBA:ARBA00022467};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          968..1027
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          2182..2217
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   DOMAIN          2225..2260
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   COILED          858..889
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2012..2046
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   2330 AA;  269827 MW;  936885F8B065596D CRC64;
     MESVGPKVLE TAEEIQERRQ EVLTRYQRFK ELVAERGQKL EDSYHYQVFR RDADDLEKWI
     LEKLKIAEDK SYEDPTNIQG KYQKHESFEA EVQAKSRVIP ELEEISKVRF AEGHFAHEDT
     KVHLEELRHL WDLLLELTRE KGILLLQALK LQQYLQECAD ILEWIGDKEA IVTSVELGED
     WERTEVLHKK FEEFQVDLAA RKGRVDRVNQ YANQCAEENH PELPLIKLKQ DEVNVSWERL
     HGLALQRQRT LSNAADLQRF KRDVTEAIQW IKEKEPQLTS EDYGKDLVSS EALFHSHKGF
     ERNLAVMDDK VKELCAKADK LRLSHPSDAP QIQQMKEDLV SNWEHIRALA TSRYTKLQAS
     YWYQRFLSDY NELSGWMKEK TALINADELP TDVAGGEALL DRHQQHKHEI DSYDDRFQSA
     DETGQALLDA NHEASDEVLE KMAILDNNWA ALKELWVRCH HQYEQCLNLH LFYRDSEQVD
     NWMSRQEAFL ENEDLGNSLG SVKALLQKHD DFEEAFTAQE EKITTLDKTA TKLIDNGHYD
     SENIADIRDG LLARRDVLRE RAVTRRRLLE DSLLLQQLYQ DSDDLKNWIN KKKKLADDED
     YKDTQNLKSR VQKQQVFEKE LAANKILLNN LEKTGQEMTE GGHYASDSVA ARVSEVESLW
     KELLEATAQK GTQLYEANQQ LQFENNAEDL KCWLVDAEKQ ATSEDYGKGL ADVQNLLRKH
     SLLESGVAAR QDQVDILTDL ATYFEETGHP DAGDVRARQE NLVSQFEALK EPLATRKKKL
     IDLLRLQQIC RDTEDEEAWI QETEPSAAST YLGKDLIASK NLLNRHEVIQ ADIASHELHI
     RVITERGNKM VEEGHFASKD VASRVKSLNE NMESLQARAA RRQNDLEANV QFQQYLADLH
     EAEAWIREKE PIVENTNYGA DEEAAGALLK KHEAFLVDLN AFGKSMQALR DQAEVCQQQQ
     AAPVERVARE ERVVALYDFQ ARSPREVTLK KDDVLTLLSS INKDWWKVEA DDHQGFVPAV
     YIRKLAHDEF PMLPQQRREE PVNITECQEQ IENQYHSLLD QAEECKCRLL QCYNEFLLAY
     EAEDMLDWIR DKKAENTGVD LDDVWELQKK FDEFQTDLKT NEPRLRDINK VADDLLFEEL
     LTPEGAQIQQ ELNARWSSLQ RLAEEQRQLL GSAHAVQMFH READDMKEQI KKKCQALSAA
     DPGSDLFSVQ ALQRQHENFE RDLIPLREKV IVLGETAERL NESHPDATDD LQRQRMELNE
     AWNDLLECTE DRKENLSEAK KFYLFLSKAR DLQNWISGLS GMVSSQELAE DLTGTEILME
     RHQEHRADME AEAPTFQALE DFGAELIGSG HYGRPEIEEK LHAVRLERNN LDKAWERRKK
     MLDQCLELQL FKGNSDQAES WMMARENFLR SDDKGSLDSL EALRKKRDDL DKAVTAQEKK
     ITELEHFAER LIADDHYAKE DIAARLQWIL DRKYLKHQAF ENEVYSRADQ MEGVISLGNS
     LIERRACDGN EETMKGQLEE LEKHWDYLLE RTIDKGQKLN EASRQQRFNT GIRDFEFWLS
     EAETLLAMKD QARDLASAGN LLKKHQLLET EMLAREDALR DLNELATDLL SSGTFNADQI
     VEKRDNVNKR YLDVQNLAAA HHEKLKEAYA LFQFFQDLDD EESWIEEKLV RVSSQDYGRD
     LQGVQNLLKK HKRLDGELMA HEPAIQNVLA MAERLGDKAA VGREEIQERL AQFVQHWEKL
     KMLAKARGLQ LEESLEYLQF MENAEEEETW ISEKKAMIAR GDSGDTLAAT QSLLKKHEAL
     DNDFAVHEAR VQNVCAQGEG ILSQEENQHK EKISVKIEAL NEKTPSLAKA IAAWKLQLED
     DYSFQQFNWK VDVVEAWIAE KETSLKTNGN GADLAAFLTL LAKQDTLDVS LHSFQQERLS
     KITNLKDQLV ASQHSQSKAI EERYAALLRH WDQLLEASAA HKDKLLEKRL PLQKAEELFM
     EFAHKASAFN HWCENTEEDL SEPVHCVSLN EIRQLQKDHE AFLASLARAQ EDLNFLRELN
     QQIKTLNVSS SPYTWLTMEV LERIWKHLTD LIKEREQELQ KEESRQLKNF EMCQEFEQNA
     SAFFQWILET RSLLKETGTL ESQLEANKDL GDNLEEALIL DIKYSTIGLA QQWDQLYQLG
     MRMQHNLEQQ IQAKDTIGVS EETLKEFSTT YKHFDENLTG RLSHKDFRSC LRGLNYYLPM
     VEEGEPEPKF EKFLDAVDPG RKGYVSLEDY TSFLIDKESE NIKSSDEIEN AFQALAEGKA
     YITKEDMKQA LTPDQVSFCA SHMQQYVDPR GRSHLAGYDY VGFTSSYFGT
//
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