ID L5KV12_PTEAL Unreviewed; 531 AA.
AC L5KV12;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Receptor-interacting serine/threonine-protein kinase 1 {ECO:0000313|EMBL:ELK15025.1};
GN ORFNames=PAL_GLEAN10016511 {ECO:0000313|EMBL:ELK15025.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK15025.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
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DR EMBL; KB030554; ELK15025.1; -; Genomic_DNA.
DR AlphaFoldDB; L5KV12; -.
DR STRING; 9402.L5KV12; -.
DR eggNOG; KOG0192; Eukaryota.
DR InParanoid; L5KV12; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0070887; P:cellular response to chemical stimulus; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:UniProt.
DR GO; GO:0031349; P:positive regulation of defense response; IEA:UniProt.
DR GO; GO:0032103; P:positive regulation of response to external stimulus; IEA:UniProt.
DR GO; GO:0010033; P:response to organic substance; IEA:UniProt.
DR GO; GO:0006950; P:response to stress; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR025735; RHIM_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR23257:SF983; RECEPTOR INTERACTING SERINE_THREONINE KINASE 1; 1.
DR PANTHER; PTHR23257; SERINE-THREONINE PROTEIN KINASE; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF12721; RHIM; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Kinase {ECO:0000313|EMBL:ELK15025.1};
KW Receptor {ECO:0000313|EMBL:ELK15025.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Transferase {ECO:0000313|EMBL:ELK15025.1};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 13..287
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 443..529
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 332..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..360
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 531 AA; 60787 MW; ED6FDC37294D6967 CRC64;
MSLDDIKMKS SDFLEKEHLD SGGFGKVSLC LHRSHGLVIL KKVYTGPKRT EYNESLLEEG
KMMHKLRHQR VVKLLGIIIE EGNYSLVMEY MEKGNLMHVL KTESSIPLSV KGRIIMETIE
GMRYLHGKNV IHKDLKPENI LVDDDFHIKI ADLGVASFKT WSKLTKEEDN KQRKVNSSSK
KNGGTLYYMA PEHLNDINAR PSEKSDVYSF AIVLWAIFAH KEPYENAICE QQLIMCIKSG
NRPDVEDIIE NCPKEIINIM KQCWEANPEV RPTFAATEQP SSLHSSQGLR IGPVEESWFA
PSPEHQQEEN ELSLQSKLQE EANYHLFGSR MDGQTKQQPR QNVAYNREEE RRRRVSHDPF
AQPKPYENVQ NPRIKGLASS SATSHDESVK CSIYNSAGIQ IGDNNYMEVG ERSSLLLDST
YTNSKEESIS KYLDIFGNTT SLTDKHLDPV RENLGRSWKI CARKLGFSES QIDEIDHDYE
RDGLKEKVYQ MLQKWLMREG NKGATVGKLT YALYQCSRTD LLNALVYISQ N
//
