ID L5KVV4_PTEAL Unreviewed; 501 AA.
AC L5KVV4;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Beta-1,4 N-acetylgalactosaminyltransferase 1 {ECO:0000313|EMBL:ELK15325.1};
GN ORFNames=PAL_GLEAN10004876 {ECO:0000313|EMBL:ELK15325.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK15325.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004323}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family.
CC {ECO:0000256|ARBA:ARBA00006739}.
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DR EMBL; KB030539; ELK15325.1; -; Genomic_DNA.
DR AlphaFoldDB; L5KVV4; -.
DR STRING; 9402.L5KVV4; -.
DR eggNOG; ENOG502QTK7; Eukaryota.
DR InParanoid; L5KVV4; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016758; F:hexosyltransferase activity; IEA:InterPro.
DR GO; GO:0034641; P:cellular nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0030259; P:lipid glycosylation; IEA:InterPro.
DR CDD; cd00761; Glyco_tranf_GTA_type; 1.
DR InterPro; IPR001173; Glyco_trans_2-like.
DR InterPro; IPR011143; GM2_synthase.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR15046:SF1; BETA-1,4 N-ACETYLGALACTOSAMINYLTRANSFERASE 1; 1.
DR PANTHER; PTHR15046; GLYCO_TRANS_2-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00535; Glycos_transf_2; 1.
DR PIRSF; PIRSF000474; GM2_GD2_synthase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Signal {ECO:0000256|SAM:SignalP};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transferase {ECO:0000313|EMBL:ELK15325.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..501
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003969491"
FT DOMAIN 281..382
FT /note="Glycosyltransferase 2-like"
FT /evidence="ECO:0000259|Pfam:PF00535"
SQ SEQUENCE 501 AA; 55365 MW; 2AC48D610DDEF247 CRC64;
MRLGRRALCV LILLLACASL GLLYARTRDA PGLRAPPALW APLQGPHRPE LLDLVPEPRY
AHIPVKIKEQ VVELLSGNNC SCESSGGSLH LPFQRQVQAI DFTKAFEPEE LKAASASREQ
EFQAFLSRSQ SAADQLLIAP ANSPLQYPLQ GVEVQPLRSI LVPGLSLHPA SGQEVYQVNL
TASLGTWDVA GEVTGVTLTG EGQPDLTLTS PGLDQLNRQL QLVTYSSRSY QANTADTVRF
STEGYEAAFT IRIRHPPNPR LYPPGSLPQG AQYNVSALVT IATKTFLRYN RLRALIASIR
RFYPTVTVVI ADDSDKPEII SGPHIEHYLM PFGKGWFAGR NLAVSQVTTK YVLWVDDDFI
FTARTRLERL VDVLERTPLD LVGEESQDKE GLQEVGGAVR EISGFATTYR QLLSLEPGAP
GRGNCLRQRR GFHHELLGFP GCVVTDGVVN FFLARTDKVR EVGFDPRLSR VAHLGLRPPS
PISGSRTLYH RLQPHPYGKN W
//
