ID L5KYG7_PTEAL Unreviewed; 486 AA.
AC L5KYG7;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Anthrax toxin receptor {ECO:0000256|PIRNR:PIRNR038023};
GN ORFNames=PAL_GLEAN10012269 {ECO:0000313|EMBL:ELK16422.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK16422.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the ATR family. {ECO:0000256|ARBA:ARBA00008095,
CC ECO:0000256|PIRNR:PIRNR038023}.
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DR EMBL; KB030472; ELK16422.1; -; Genomic_DNA.
DR AlphaFoldDB; L5KYG7; -.
DR STRING; 9402.L5KYG7; -.
DR eggNOG; ENOG502QT7Y; Eukaryota.
DR InParanoid; L5KYG7; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR CDD; cd01474; vWA_ATR; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR017360; Anthrax_toxin_rcpt.
DR InterPro; IPR008399; Anthrax_toxin_rcpt_C.
DR InterPro; IPR008400; Anthrax_toxin_rcpt_extracel.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR16059; ANTHRAX TOXIN RECEPTOR; 1.
DR PANTHER; PTHR16059:SF13; ANTHRAX TOXIN RECEPTOR 2; 1.
DR Pfam; PF05586; Ant_C; 1.
DR Pfam; PF05587; Anth_Ig; 1.
DR Pfam; PF00092; VWA; 1.
DR PIRSF; PIRSF038023; Anthrax_toxin_receptor_2; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR038023-2};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR038023};
KW Metal-binding {ECO:0000256|PIRNR:PIRNR038023,
KW ECO:0000256|PIRSR:PIRSR038023-1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|PIRNR:PIRNR038023, ECO:0000313|EMBL:ELK16422.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..486
FT /note="Anthrax toxin receptor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003969628"
FT TRANSMEM 319..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 44..213
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 425..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 52
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /evidence="ECO:0000256|PIRSR:PIRSR038023-1"
FT BINDING 54
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /evidence="ECO:0000256|PIRSR:PIRSR038023-1"
FT BINDING 118
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /evidence="ECO:0000256|PIRSR:PIRSR038023-1"
FT DISULFID 39..218
FT /evidence="ECO:0000256|PIRSR:PIRSR038023-2"
SQ SEQUENCE 486 AA; 53244 MW; D7357AC37A5A97E1 CRC64;
MVAGLSLAHS PGSWLVPGLW LLALCGPGGL LRAQEQPSCR GAFDLYFVLD KSGSVANNWI
EIYNFVQQLT ERFVSPQMRL SFIVFSSQAT IILPLTGDRG KISKGLEDLK HVVPTGETYI
HEGLKLANEQ IQKAGGFKTS SIVIALTDGK LDGLVPSYAE KEAKVSRSFG ARVYCVGVLD
FEQAQLERIA DSKEQVFPVK GGFQALKGII NSILAQSCTE ILELQPSSVC VGEKFQIVLN
GRGFNLGSRH DSVLCTYTVN ETYTKSVKPV SVELNSMLCP APTLNKVGET LDVSVSFNGG
KSVISSSLLV TATECSNGVA AIIAILVLLL LLGIGLMWWF WPLCCKVVIK DPLPPPPPSA
PVEEEEEPLP NKKWPTVDAS YYGGRGVGGI KRMEVRWGDK GSTEEGARLE KAKNAVVTIP
EEVEEPIRPK PPRPKPTYQP PQTKWYTPIK GRLDALWALL RRQYDRVSLM RPQEGDEVCM
WECVGK
//
