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Database: UniProt
Entry: L5KYX2_PTEAL
LinkDB: L5KYX2_PTEAL
Original site: L5KYX2_PTEAL 
ID   L5KYX2_PTEAL            Unreviewed;      2137 AA.
AC   L5KYX2;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   25-OCT-2017, entry version 24.
DE   RecName: Full=Voltage-dependent R-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   ORFNames=PAL_GLEAN10017696 {ECO:0000313|EMBL:ELK16206.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Megachiroptera;
OC   Pteropodidae; Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK16206.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y.,
RA   Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y.,
RA   Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G.,
RA   Wang L.F., Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the
RT   evolution of flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1E
CC       gives rise to R-type calcium currents. R-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA).
CC       They are however insensitive to dihydropyridines (DHP), omega-
CC       conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega-
CC       Aga-IVA). Calcium channels containing alpha-1E subunit could be
CC       involved in the modulation of firing patterns of neurons which is
CC       important for information processing.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; KB030474; ELK16206.1; -; Genomic_DNA.
DR   InParanoid; L5KYX2; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005449; VDCC_R_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF57; PTHR10037:SF57; 2.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 5.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01633; RVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000010552};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     26     44       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     88    110       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    162    183       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    195    217       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    326    346       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    352    370       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    452    474       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    529    552       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    984   1003       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1056   1073       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1117   1139       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1229   1254       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1310   1328       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1340   1363       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1369   1388       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1395   1415       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1485   1509       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1646   1680       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      548    575       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2137 AA;  240686 MW;  98DECA518AEE4085 CRC64;
     MRGTLCLTRD LELTFQNDDT GEESPALVTS ILCLSLCSIL ATAGTHFNTH VDLRTLRAVR
     VLRPLKLVSG IPSLQIVLKS IMKAMVPLLQ IGLLLFFAIL MFAIIGLEFY SGKLHRACFM
     NNSGILEGFD PPHPCGVQGC PAGYECKDWI GPNDGITQFD NILFAVLTVF QCITMEGWTT
     VLYNTNDALG ATWNWLYFIP LIIIGSFFVL NLVLGVLSGE FAKERERVEN RRAFMKLRRQ
     QQIERELNGY RAWIDKAVLR RATIKRSRTE AMTRDSSDEH CVDISSVGTP LARASIKSTK
     VDGASYFRHK ERLLRISVRH MVKSQVFYWI VLSLVALNTA CVAIVHHNQP QWLTHLLYYA
     EFLFLGLFLL EMSLKMYGMG PRLYFHSSFN CFDFGVTVGS IFEVVWAIFR PGTSFGISVL
     RALRLLRIFK ITKYWASLRN LVVSLMSSMK SIISLLFLLF LFIVVFALLG MQLFGGRFNF
     NDGTPSANFD TFPAAIMTVF QILTGEDWNE VMYNGIRSQG GVSSGMWSAI YFIVLTLFGN
     YTLLNVFLAI AVDNLANAQE LTKDEQEEEE AFNQKHALQK AKEVSPMSAP NMPSIERERR
     RRHHMSVWEQ RTSQLRRHMQ MSSQEALNKE EAPPMNPLNP LNPLSPLNPL NAHPSLYRRP
     RALEGLALGL EKCEEERGSR GGSLKGDSGD LSSALDNQKS PLSLGKREPP WPARPCHGNC
     DPMQQEARGG ETVVTFEDRA RHRQSQRRSR HRRVRTEGKE PSSASRSRSA SQERSLDDGT
     PADGEKGREP RSSRGAKEPT IQEEERAQHL RRTNSLMVSR GSGLAGALDE ADTPLVLPQP
     ELDVGKDTAL TEQEPEPEPE GSSEQALLGE VQLDVGRAIS QSEPDLSCVT ANTDKAATES
     TSVTVAIPDV DPLVDSAVVH ISSKTDGEAS PLKEAELKEE EETLGKQPQQ DKRETGKAMV
     PHSSMFIFST TNPIRRACHY IVNLRYFEMC ILLVIAASSI ALAAEDPVLT NSERNRVLRY
     FDYVFTGVFT FEMVIKMVDQ GLILQDGSYF RDLWNILDFI VVVGALVAFA LATNKGRDIK
     TIKSLRVLRV LRPLKTIKRL PKLKAVFDCV VTSLKNVFNI LIVYKLFMFI FAVIAVQLFK
     GKFFYCTDSS KDTEKECIGN YVDHEKNKME VKGREWKRHE FHYDNIVWAL LTLFTVSTGE
     GWPQVLQHSV DVTEEDRGPS RSNRMEMSIF YVVYFVVFPF FFVNIFVALI IITFQEQGDK
     MMEECSLEKN ERACIDFAIS AKPLTRYMPQ NRHTFQYRVW HFVVSPSFEY TIMAMIALNT
     IVLMMKYYSA PCTYELALKY LNIAFTMVFS LECVLKIIAF GFLNYFRDTW NIFDFITVIG
     SITEIILTDS KALPYVCLLI AMLFFIYAII GMQVFGNIKL DEESHINRHN NFRSFFGSLM
     LLFRSATGEA WQEIMLSCLG EKGCEPDTTA PSGQSENERC GTDLAYVYFV SFIFFCSFLM
     LNLFVAVIMD NFEYLTRDSS ILGPHHLDEF VRVWAEYDRA ACGRIPYKDM YKLVRVISPP
     LGLGENCPYR VACKRLVLMN MPVAEDMTVH FTSTLMALIR TALDIKIAKG GADRQQLDSE
     LQKETLAIWP HLSQKMLDLL VPMPKASDLT VGKIYAAMMI MDYYKQSKVK KQRQQLEEQK
     NAPMFQRMEP SSLPQEIIAN ANALPYLQQD PGSGLSGRGG YPAMRPLSPQ EIFQLACMDP
     ADDGQCQEQQ SLEPEVSELK SVQPSNHGIY LPPDTQEHAG SGRASSMPRL TVDPQVVTDP
     SSMRRSFSTI RDKRSNSSWL EEFSMERSSE NTYKSRRRSY HSSLRLSAHR LNADSGHKSD
     THRSGGRERG RSKERKHLLS PDVSRCNSEE RGTQADWESP ERRPSRSPSE GRSQTPNREG
     TGSLSESSIP SISDTSTPRR SRRQLPPVPP KPRPLLSYSS LLRHTGSVSP PADGSEGGSL
     LTSQVLEGGE GGPPAPSSSR HTQQGPHPSP QRYISEPYLA LHEDAHTSDC GEEETLTFEA
     AVATSLGRAN TIXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXRHSW
     QMPNGHYRRR RRGGPGPGMM CGGVGDLLSD TEEDDKC
//
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